Evidence map›Paper›PMID 29034584›Full record

ReviewAdvanced healthcare materials2017

Modern Therapeutic Approaches for Noninfectious Ocular Diseases Involving Inflammation.

Michelle L Ratay, Elena Bellotti, Riccardo Gottardi, Steven R Little

Open access · greenAbstract readReview
In one paragraph

Review in Advanced healthcare materials, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Michelle L RatayDepartment of Bioengineering, University of Pittsburgh, 427 Benedum Hall 3700 O'Hara Street, Pittsburgh, PA, 15261, USA.
Elena BellottiDepartment of Chemical Engineering, University of Pittsburgh, 427 Benedum Hall 3700 O'Hara Street, Pittsburgh, PA, 15261, USA.
Riccardo GottardiDepartment of Chemical Engineering, Department of Orthopedic Surgery, Ri.MED Foundation, 427 Benedum Hall 3700 O'Hara Street, Pittsburgh, PA, 15261, USA.ORCID http://orcid.org/0000-0001-8040-5531
Steven R LittleDepartment of Chemical Engineering, Department of Bioengineering, Department of Ophthalmology, Department of Immunology, Department of Pharmaceutical Sciences, The McGowan Institute for Regenerative Medicine, 940 Benedum Hall 3700 O'Hara Street, Pittsburgh, PA, 15261, USA.
University of Pittsburgh · USField Foundation · USMcGowan Institute for Regenerative Medicine · US

Funding

Virus Production and Manipulation of Protein/Gene Expression ModuleP30EY008098 · NEI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Ethan A Rossi · 1989 to 2026
$17.8M
Combined Hydrogel/Microparticle Eye Drops for Sustained Delivery of Glaucoma MedicationR01EY024039 · NEI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LITTLE, STEVEN R · 2015 to 2019
$1.6M
University of Pittsburgh Clinical and Translational Science InstituteTL1TR000145 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2012 to 2015
$872k
NCATS NIH HHS TL1 TR000145NEI NIH HHS P30 EY008098NEI NIH HHS R01 EY024039
6 · The paper itself

Abstract

Dry eye disease, age-related macular degeneration, and uveitis are ocular diseases that significantly affect the quality of life of millions of people each year. In these diseases, the action of chemokines, proinflammatory cytokines, and immune cells drives a local inflammatory response that results in ocular tissue damage. Multiple therapeutic strategies are developed to either address the symptoms or abate the underlying cause of these diseases. Herein, the challenges to deliver drugs to the relevant location in the eye for each of these diseases are reviewed along with current and innovative therapeutic approaches that attempt to restore homeostasis within the ocular microenvironment.

Indexed as

AnimalsChemokinesHumansInflammationMacular DegenerationUveitisChemokinesage-related macular degenerationdrug deliverydry eye diseasetherapeuticsuveitis

Identifiers

PMID29034584
PMCPMC5915344
OpenAlexW2763329894

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.