SynthesisJournal of internal medicine2018
Association between subclinical thyroid dysfunction and change in bone mineral density in prospective cohorts.
Synthesis in Journal of internal medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 4 syntheses or guidelines pooled it, 87 citations in OpenAlex.
- Association between serum TSH concentration and bone mineral density: an umbrella review.Hormones (Athens, Greece) · 2024Pooled it
- An individual participant data analysis of prospective cohort studies on the association between subclinical thyroid dysfunction and depressive symptoms.Scientific reports · 2020Pooled it
- Effect of subclinical hyperthyroidism on osteoporosis: A meta-analysis of cohort studies.Endocrine · 2020Pooled it
- Association of subclinical thyroid dysfunction with bone mineral density and fracture: a meta-analysis of prospective cohort studies.Endocrine · 2020Pooled it
- The Osteoporotic Fractures in Men study (MrOS): a 25-yr landmark study of skeletal health in older men.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2026Article
- Thyroid dysfunction alters gut microbiota composition and alveolar bone levels in female mice.Physiological reports · 2026Article
- TSH suppression attenuates the early efficacy of zoledronic acid in osteoporosis.Archives of osteoporosis · 2026Article
- Bone mineral density assessment by DXA in disease-associated osteoporosis: the limitations.Frontiers in endocrinology · 2026Review
- Thyroid dysfunction in ageing populations.Endocrine connections · 2025Review
- Thyroid dysfunction and osteoporosis: A two-sample bidirectional Mendelian randomization study.Medicine · 2025Article
- Are Dietary Habits the Missing Link Between Hashimoto's Thyroiditis and Osteoporosis?Nutrients · 2025Review
- Exploring the mediating role of thyroid function in the effect of celiac disease on osteoporosis: A Mendelian randomization study.Medicine · 2025Article
- Effects of vitamin DEndocrine · 2025Article
- Considerations in the Diagnosis and Management of Thyroid Dysfunction in Older Adults.Thyroid : official journal of the American Thyroid Association · 2025Review
- Increased risk of multisystem comorbidities and disease trajectories following hyperthyroidism: evidence from the 0.5 million UK Biobank population.Endocrine connections · 2025Article
- Establishing the TSH reference intervals for healthy adults aged over 70 years: the Australian ASPREE cohort study.Clinical chemistry and laboratory medicine · 2025Article
- The association between thyroid function and insulin resistance as measured by the metabolic score for insulin resistance (METS-IR): insights from NHANES 2007-2012.BMC endocrine disorders · 2024Article
- Neuroendocrinology of bone.Pituitary · 2024Review
- Higher serum free thyroxine levels are associated with increased risk of hip fractures in older men.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024Article
- The ageing thyroid: implications for longevity and patient care.Nature reviews. Endocrinology · 2024Review
Corrections and comments
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Authors and funding
27 authors at 12 institutions in 4 countries.
Funding
Abstract
backgroundSubclinical hyperthyroidism (SHyper) has been associated with increased risk of hip and other fractures, but the linking mechanisms remain unclear.
objectiveTo investigate the association between subclinical thyroid dysfunction and bone loss.
methodsIndividual participant data analysis was performed after a systematic literature search in MEDLINE/EMBASE (1946-2016). Two reviewers independently screened and selected prospective cohorts providing baseline thyroid status and serial bone mineral density (BMD) measurements. We classified thyroid status as euthyroidism (thyroid-stimulating hormone [TSH] 0.45-4.49 mIU/L), SHyper (TSH < 0.45 mIU/L) and subclinical hypothyroidism (SHypo, TSH ≥ 4.50-19.99 mIU/L) both with normal free thyroxine levels. Our primary outcome was annualized percentage BMD change (%ΔBMD) from serial dual X-ray absorptiometry scans of the femoral neck, total hip and lumbar spine, obtained from multivariable regression in a random-effects two-step approach.
resultsAmongst 5458 individuals (median age 72 years, 49.1% women) from six prospective cohorts, 451 (8.3%) had SHypo and 284 (5.2%) had SHyper. During 36 569 person-years of follow-up, those with SHyper had a greater annual bone loss at the femoral neck versus euthyroidism: %ΔBMD = -0.18 (95% CI: -0.34, -0.02; I
conclusionAmongst adults, SHyper was associated with increased femoral neck bone loss, potentially contributing to the increased fracture risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.