ReviewJournal of neuroscience research2018
The role of spontaneous neurotransmission in synapse and circuit development.
Review in Journal of neuroscience research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
47 citing papers in PubMed.
- Lipid Disorder and PIP2-Regulated Clustering of Syntaxin-1 JMD-TMD Regions Govern Membrane Fusion Competence.International journal of molecular sciences · 2026Article
- Audiovisual gamma stimulation restores hippocampal neurogenesis and neural circuit plasticity in aging mice.Molecular psychiatry · 2026Article
- Functional Nano-segregation of Distinct Forms of Neurotransmission.Advances in neurobiology · 2026Review
- Transient Inhibition of the Mediodorsal Thalamus During Early Adolescence Induces Hypofrontality and Social Memory Deficits in Young Adulthood.Biological psychiatry global open science · 2025Article
- Dual Mechanisms of the Diazepine-Benzimidazole Derivative, DAB-19, in Modulating Glutamatergic Neurotransmission.International journal of molecular sciences · 2025Article
- Distinct transmission sites within a synapse for strengthening and homeostasis.Science advances · 2025Article
- Three systems of circuit formation: assembly, updating and tuning.Nature reviews. Neuroscience · 2025Review
- Sortilin and L-type Calcium Channels May be Involved in the Unusual Mechanism of proBDNF Signaling in Regenerating Mouse Neuromuscular Junctions.Neurochemical research · 2025Article
- High frequency stimulation activates hot spots of spontaneous synaptic transmission.Frontiers in synaptic neuroscience · 2025Article
- On the Principle and Value of Test Signaling ("Pinging") in Pain Pathways: A Part of an Overarching Principle in Psychophysical Phenomena?Journal of pain research · 2025Article
- Glutamate Signaling and Neuroligin/Neurexin Adhesion Play Opposing Roles That Are Mediated by Major Histocompatibility Complex I Molecules in Cortical Synapse Formation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Glial Control of Cortical Neuronal Circuit Maturation and Plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- Transsynaptic BMP Signaling Regulates Fine-Scale Topography between Adjacent Sensory Neurons.eNeuro · 2024Article
- Article
- Direct Current Stimulation Modulates Synaptic Facilitation via Distinct Presynaptic Calcium Channels.International journal of molecular sciences · 2023Article
- Microtubule depolymerization contributes to spontaneous neurotransmitter release in vitro.Communications biology · 2023Article
- Depolarization-induced bursts of miniature synaptic currents in individual synapses of developing cerebellum.The Journal of general physiology · 2023Article
- Endogenous Modulators of NMDA Receptor Control Dendritic Field Expansion of Cortical Neurons.Molecular neurobiology · 2023Article
- Editorial: Emerging frontiers in developmental biology in Latin America.Frontiers in neuroscience · 2023Article
- HIV-1 envelope protein gp120 modulation of glutamate effects on cortical neuronal synapses: implications for HIV-1-associated neuropathogenesis.International journal of physiology, pathophysiology and pharmacology · 2023Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
In the past, the spontaneous release of neurotransmitter from presynaptic terminals has been thought of as a side effect of evoked release, with little functional significance. As our understanding of the process of spontaneous release has increased over time, this notion has gradually changed. In this review, we focus on the importance of this form of release during neuronal development, a time of extreme levels of plasticity that includes the growth of dendrites and axons as well as the formation of new synaptic contacts. This period also encompasses high levels of neurotransmitter release from growing axons, and recent studies have found that spontaneous transmitter release plays an important role in shaping neuronal morphology as well as modulating the properties of newly forming synaptic contacts in the brain. Here, we bring together the latest findings across different species to argue that the spontaneous release of neurotransmitter is an important player in the wiring of the brain during development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.