ArticleAnnals of neurology2017
Effect of sensory and motor connectivity on hand function in pediatric hemiplegia.
Article in Annals of neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 59 citations in OpenAlex.
- Corpus Callosum Integrity Relates to Improvement of Upper-Extremity Function Following Intensive Rehabilitation in Children With Unilateral Spastic Cerebral Palsy.Neurorehabilitation and neural repair · 2021Trial
- Functional connectivity and upper limb function in patients after pediatric arterial ischemic stroke with contralateral corticospinal tract wiring.Scientific reports · 2021Trial
- Anatomical and Functional Characterization in Children With Unilateral Cerebral Palsy: An Atlas-Based Analysis.Neurorehabilitation and neural repair · 2020Trial
- Bilateral Mechanoreception Discrimination based on Bihemispheric Somatosensory Response Patterns is Associated with Proprioception and Motor Function After Stroke.bioRxiv : the preprint server for biology · 2026Article
- Modeling cerebral palsy in animals.Developmental medicine and child neurology · 2026Review
- Methodological optimization for eliciting robust median nerve somatosensory evoked potentials for realtime single trial applications.Journal of neural engineering · 2026Article
- Functional and structural neuroplasticity of somatosensory system in hemiplegic cerebral palsy.Brain communications · 2026Article
- Extracting robust single-trial somatosensory evoked potentials for non-invasive brain computer interfaces.Journal of neural engineering · 2025Article
- Impact of Brain Lesion Characteristics on Motor Function and Cortical Reorganization in Hemiplegic Cerebral Palsy.Medicina (Kaunas, Lithuania) · 2025Article
- Neural Encoding of Direction and Distance across Reference Frames in Visually Guided Reaching.eNeuro · 2024Article
- Tractography of sensorimotor pathways in dyskinetic cerebral palsy: Association with motor function.Annals of clinical and translational neurology · 2024Article
- Sensory Symptoms Across the Lifespan in People With Cerebral Palsy.Pediatric neurology · 2024Article
- Disruption of Sensorimotor Cortical Oscillations by Visual Interference Predicts the Altered Motor Performance of Persons with Cerebral Palsy.Neuroscience · 2024Article
- Article
- Limb-specific thalamocortical tracts are impaired differently in hemiplegic and diplegic subtypes of cerebral palsy.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Neural Correlates of Impaired Grasp Function in Children with Unilateral Spastic Cerebral Palsy.Brain sciences · 2023Review
- Combining Unimanual and Bimanual Therapies for Children with Hemiparesis: Is There an Optimal Delivery Schedule?Behavioral sciences (Basel, Switzerland) · 2023Article
- Corticomuscular Coherence in Children with Unilateral Cerebral Palsy: A Feasibility and Preliminary Protocol Study.Journal of child neurology · 2023Article
- Neuro-imaging characteristics of sensory impairment in cerebral palsy; a systematic review.Frontiers in rehabilitation sciences · 2023Review
- Enhanced nociceptive behavior and expansion of associated primary afferents in a rabbit model of cerebral palsy.Journal of neuroscience research · 2022Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
objectiveWe tested the hypothesis that somatosensory system injury would more strongly affect movement than motor system injury in children with unilateral cerebral palsy (USCP). This hypothesis was based on how somatosensory and corticospinal circuits adapt to injury during development; whereas the motor system can maintain connections to the impaired hand from the uninjured hemisphere, this does not occur in the somatosensory system. As a corollary, cortical injury strongly impairs sensory function, so we hypothesized that cortical lesions would impair hand function more than subcortical lesions.
methodsTwenty-four children with unilateral cerebral palsy had physiological and anatomical measures of the motor and somatosensory systems and lesion classification. Motor physiology was performed with transcranial magnetic stimulation and somatosensory physiology with vibration-evoked electroencephalographic potentials. Tractography of the corticospinal tract and the medial lemniscus was performed with diffusion tensor imaging, and lesions were classified by magnetic resonance imaging. Anatomical and physiological results were correlated with measures of hand function using 2 independent statistical methods.
resultsChildren with disruptions in the somatosensory connectivity and cortical lesions had the most severe upper extremity impairments, particularly somatosensory function. Motor system connectivity was significantly correlated with bimanual function, but not unimanual function or somatosensory function.
interpretationBoth sensory and motor connectivity impact hand function in children with USCP. Somatosensory connectivity could be an important target for recovery of hand function in children with USCP. Ann Neurol 2017;82:766-780.
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Registered trials
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