Evidence map›Paper›PMID 29034321›Full record

ArticleJournal of nature and science2017

Refractory versus resistant hypertension: Novel distinctive phenotypes.

Tanja Dudenbostel, Mohammed Siddiqui, Nitin Gharpure, David A Calhoun

Abstract read
In one paragraph

Article in Journal of nature and science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Refractory hypertension: what do we know so far?Journal of human hypertension · 2021
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Resistant Hypertension Updated Guidelines.Current cardiology reports · 2019
    Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Refractory hypertension focus on nighttime blood pressure and nondipping.Journal of clinical hypertension (Greenwich, Conn.) · 2018
    Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Tanja DudenbostelVascular Biology and Hypertension Program, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Mohammed SiddiquiVascular Biology and Hypertension Program, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Nitin GharpureVascular Biology and Hypertension Program, University of Alabama at Birmingham, Birmingham, Alabama, USA.
David A CalhounVascular Biology and Hypertension Program, University of Alabama at Birmingham, Birmingham, Alabama, USA.

Funding

University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Kirk Michael Habegger · 2013 to 2026
$19.5M
MECHANISMS OF HYPERTENSION AND CARDIOVASCULAR DISEASEST32HL007457 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Martin E Young · 1985 to 2026
$8.6M
Mechanisms of Refractory HypertensionR01HL113004 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI OPARIL, SUZANNE · 2014 to 2018
$2.5M
NHLBI NIH HHS R01 HL113004NHLBI NIH HHS T32 HL007457NIDDK NIH HHS P30 DK079626
6 · The paper itself

Abstract

Resistant hypertension (RHTN) is relatively common with an estimated prevalence of 10-20% of treated hypertensive patients. It is defined as blood pressure (BP) >140/90 mmHg treated with ≥3 antihypertensive medications, including a diuretic, if tolerated. Refractory hypertension is a novel phenotype of severe antihypertensive treatment failure. The proposed definition for refractory hypertension, i.e. BP >140/90 mmHg with use of ≥5 different antihypertensive medications, including a diuretic

Indexed as

Aldosteroneantihypertensive treatment failuresympathetic activitytreatment resistancevolume dependent

Identifiers

PMID29034321
PMCPMC5640321

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.