ReviewFrontiers in medicine2017
Coagulofibrinolytic Changes in Patients with Post-cardiac Arrest Syndrome.
Review in Frontiers in medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 58 citations in OpenAlex.
- Hemostasis, coagulation and thrombin in venoarterial and venovenous extracorporeal membrane oxygenation: the HECTIC study.Scientific reports · 2021Trial
- A machine learning framework for multimodal temporal prediction of neurological outcome after out-of-hospital cardiac arrest.Scientific reports · 2026Article
- Association of alkaline phosphatase to platelet ratio index with ICU mortality in patients with cardiac arrest.BMC cardiovascular disorders · 2026Article
- Predictors of Bleeding Complications After Extracorporeal Cardiopulmonary Resuscitation: Insights From the SAVE-J II Study.JACC. Asia · 2026Article
- The relationships between disseminated intravascular coagulation and time series change of Von Willebrand factor in patients with out-of-hospital cardiac arrest: a retrospective observational study.Thrombosis journal · 2026Article
- Platelets as Central Modulators of Post-Cardiac Arrest Syndrome: Mechanisms and Therapeutic Implications.Biomolecules · 2026Review
- Narrative Review: Research Progress and Future Directions of Presepsin in Neurological Prognostication of Adult Post-Return of Spontaneous Circulation (Post-ROSC) Cardiac Arrest Survivors.Journal of inflammation research · 2026Review
- Disseminated intravascular coagulation is associated with a poor outcome in patients with out-of-hospital cardiac arrest receiving VA-ECMO.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2025Article
- Association between fibrinogen levels and mortality following cardiopulmonary resuscitation: a retrospective cohort study.Resuscitation plus · 2025Article
- Disseminated intravascular coagulation.Journal of intensive care · 2025Review
- Article
- Optimal Timing of the Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio as Early Predictors of Neurological Outcomes in Postcardiac Arrest Patients.Life (Basel, Switzerland) · 2024Article
- Association of hyperfibrinolysis with poor prognosis in refractory circulatory arrest: implications for extracorporeal cardiopulmonary resuscitation.British journal of anaesthesia · 2024Article
- The Association between Disseminated Intravascular Coagulation Profiles and Neurologic Outcome in Patients with In-Hospital Cardiac Arrest.Reviews in cardiovascular medicine · 2024Article
- Bleeding and Thrombosis in Patients With Out-of-Hospital Ventricular Tachycardia/Ventricular Fibrillation Arrest Treated With Extracorporeal Cardiopulmonary Resuscitation.Journal of the American Heart Association · 2024Article
- Cardiac arrest, stony heart, and cardiopulmonary resuscitation: An updated revisit.World journal of cardiology · 2024Review
- Coagulofibrinolytic effects of recombinant soluble thrombomodulin in prolonged porcine cardiac arrest.Resuscitation plus · 2023Article
- Performance of the systemic immune-inflammation index in predicting survival to discharge in out-of-hospital cardiac arrest.Resuscitation plus · 2023Article
- Association between prothrombin time-international normalized ratio and prognosis of post-cardiac arrest patients: A retrospective cohort study.Frontiers in public health · 2023Article
- SHock-INduced Endotheliopathy (SHINE): A mechanistic justification for viscoelastography-guided resuscitation of traumatic and non-traumatic shock.Frontiers in physiology · 2023Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Whole-body ischemia and reperfusion due to cardiac arrest and subsequent return of spontaneous circulation constitute post-cardiac arrest syndrome (PCAS), which consists of four syndromes including systemic ischemia/reperfusion responses and post-cardiac arrest brain injury. The major pathophysiologies underlying systemic ischemia/reperfusion responses are systemic inflammatory response syndrome and increased coagulation, leading to disseminated intravascular coagulation (DIC), which clinically manifests as obstruction of microcirculation and multiple organ dysfunction. In particular, thrombotic occlusion in the brain due to DIC, referred to as the "no-reflow phenomenon," may be deeply involved in post-cardiac arrest brain injury, which is the leading cause of mortality in patients with PCAS. Coagulofibrinolytic changes in patients with PCAS are characterized by tissue factor-dependent coagulation, which is accelerated by impaired anticoagulant mechanisms, including antithrombin, protein C, thrombomodulin, and tissue factor pathway inhibitor. Damage-associated molecular patterns (DAMPs) accelerate not only tissue factor-dependent coagulation but also the factor XII- and factor XI-dependent activation of coagulation. Inflammatory cytokines are also involved in these changes
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