Evidence map›Paper›PMID 29034114›Full record

ArticlePolymers2016

Cationic Nanocylinders Promote Angiogenic Activities of Endothelial Cells.

Jung Bok Lee, Daniel A Balikov, Jae Won Yang, Ki Seok Kim, Hun Kuk Park, Jeong Koo Kim, Il Keun Kwon, Leon M Bellan, Hak-Joon Sung

Open access · goldAbstract read
In one paragraph

Article in Polymers, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Jung Bok LeeDepartment of Biomedical Engineering, Vanderbilt University, Nashville, TN 37212, USA.
Daniel A BalikovDepartment of Biomedical Engineering, Vanderbilt University, Nashville, TN 37212, USA.
Jae Won YangDepartment of Internal Medicine, Yonsei University of Wonju College of Medicine, Wonju, Gangwon 220-701, Korea.
Ki Seok KimDepartment of Medical Engineering, College of Medicine, Kyung Hee University, Seoul 130-701, Korea.
Hun Kuk ParkDepartment of Medical Engineering, College of Medicine, Kyung Hee University, Seoul 130-701, Korea.
Jeong Koo KimDepartment of Biomedical Engineering, Vanderbilt University, Nashville, TN 37212, USA.
Il Keun KwonDepartment of Maxillofacial Biomedical Engineering and Institute of Oral Biology, School of Dentistry, Kyung Hee University, Seoul 130-701, Korea.
Leon M BellanDepartment of Biomedical Engineering, Vanderbilt University, Nashville, TN 37212, USA.
Hak-Joon SungDepartment of Biomedical Engineering, Vanderbilt University, Nashville, TN 37212, USA.
Kyung Hee University · KRVanderbilt University · USYonsei University · KRInje University · KR

Funding

VANDERBILT UNIVERSITY CTSA FOR PEDIATRIC RESEARCHUL1RR024975 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$45.7M
The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007347 · NIGMS · VANDERBILT UNIVERSITY · PI WILLIAMS, CHRISTOPHER S. · 1985 to 2023
$26.3M
Neurovascular Unit on a Chip: Chemical Communication, Drug and Toxin ResponsesUH2TR000491 · NCATS · VANDERBILT UNIVERSITY · PI NISWENDER, KEVIN D, WEBB, DONNA J · 2012 to 2013
$2.2M
Thermosensitive injectable polymer-based stem cell therapy for limb ischemiaR21EB019509 · NIBIB · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SUNG, HAK-JOON, YOUNG, PAMPEE P · 2015 to 2016
$433k
NCATS NIH HHS UH2 TR000491NCATS NIH HHS UL1 TR000445NCRR NIH HHS UL1 RR024975NIBIB NIH HHS R21 EB019509NIGMS NIH HHS T32 GM007347
6 · The paper itself

Abstract

Polymers have been used extensively taking forms as scaffolds, patterned surface and nanoparticle for regenerative medicine applications. Angiogenesis is an essential process for successful tissue regeneration, and endothelial cell-cell interaction plays a pivotal role in regulating their tight junction formation, a hallmark of angiogenesis. Though continuous progress has been made, strategies to promote angiogenesis still rely on small molecule delivery or nuanced scaffold fabrication. As such, the recent paradigm shift from top-down to bottom-up approaches in tissue engineering necessitates development of polymer-based modular engineering tools to control angiogenesis. Here, we developed cationic nanocylinders (NCs) as inducers of cell-cell interaction and investigated their effect on angiogenic activities of human umbilical vein endothelial cells (HUVECs)

Indexed as

cationic nanocylindercell–cell interactionendothelial cellsmigrationtubulogenesis

Identifiers

PMID29034114
PMCPMC5639919
OpenAlexW2236774779

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.