Evidence map›Paper›PMID 29034095›Full record

ReviewJournal of therapeutic ultrasound2017

Current and emerging brain applications of MR-guided focused ultrasound.

Ying Meng, Suganth Suppiah, Karim Mithani, Benjamin Solomon, Michael L Schwartz, Nir Lipsman

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of therapeutic ultrasound, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
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  11. Review
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  14. Focused Ultrasound Strategies for Brain Tumor Therapy.Operative neurosurgery (Hagerstown, Md.) · 2020
    Review
  15. Article
  16. Article
  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ying MengDivision of Neurosurgery, Department of Surgery, Sunnybrook Health Sciences Centre, University of Toronto, 2075 Bayview Avenue, Toronto, ON Canada.ORCID 0000-0003-3180-2404
Suganth SuppiahDivision of Neurosurgery, Department of Surgery, Sunnybrook Health Sciences Centre, University of Toronto, 2075 Bayview Avenue, Toronto, ON Canada.
Karim MithaniPhysical Sciences Platform, Sunnybrook Research Institute, Toronto, ON Canada.
Benjamin SolomonPhysical Sciences Platform, Sunnybrook Research Institute, Toronto, ON Canada.
Michael L SchwartzDivision of Neurosurgery, Department of Surgery, Sunnybrook Health Sciences Centre, University of Toronto, 2075 Bayview Avenue, Toronto, ON Canada.
Nir LipsmanDivision of Neurosurgery, Department of Surgery, Sunnybrook Health Sciences Centre, University of Toronto, 2075 Bayview Avenue, Toronto, ON Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MRI guided focused ultrasound is an emerging technique that uses acoustic energy to noninvasively treat intracranial disorders. At high frequencies, it can be used to raise tissue temperatures and ablate discrete brain targets with sub-millimeter accuracy. This application is currently under investigation for a broad range of clinical applications, including brain tumors, movement disorders, and psychiatric conditions. At low frequencies MRI guided focused ultrasound can be used to modulate neuronal activity and in conjunction with injected microbubbles, can open the blood-brain barrier to enhance the delivery of therapeutic compounds. The last decade has seen dramatic advances in the science of MRI guided focused ultrasound, helping elucidate both its mechanisms and potential in pre-clinical models, and its translational promise across myriad clinical applications. This review provides an update of current and emerging MRI guided focused ultrasound applications for intracranial disorders and describes future directions and challenges for the field.

Indexed as

Blood-brain barrier disruptionFocused ultrasoundMRgFUSMRI guided focused ultrasoundNeuroablationNeurologic disorders

Identifiers

PMID29034095
PMCPMC5629772

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.