ReviewFrontiers in immunology2017
Early-Life Nutritional Factors and Mucosal Immunity in the Development of Autoimmune Diabetes.
Review in Frontiers in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- Gut microbiota and the early prevention window in type 1 diabetes and latent autoimmune diabetes in adults: a state-of-the-art narrative review on diet and metabolites.Frontiers in endocrinology · 2026Review
- Targeted nutritional intervention attenuates experimental lung cancer cachexia.Journal of cachexia, sarcopenia and muscle · 2024Article
- Interactions of human milk oligosaccharides with the immune system.Frontiers in immunology · 2024Review
- Immunomodulatory Effects of Microbiota-Derived Short-Chain Fatty Acids in Autoimmune Liver Diseases.Journal of immunology (Baltimore, Md. : 1950) · 2023Review
- Study of the gut microbiome in Egyptian patients with type 1 diabetes mellitus.Przeglad gastroenterologiczny · 2023Article
- Early-life fingolimod treatment improves intestinal homeostasis and pancreatic immune tolerance in non-obese diabetic mice.Acta pharmacologica Sinica · 2021Article
- An Expert Panel Statement on the Beneficial Effects of Human Milk Oligosaccharides (HMOs) in Early Life and Potential Utility of HMO-Supplemented Infant Formula in Cow's Milk Protein Allergy.Journal of asthma and allergy · 2021Review
- Prenatal and postnatal determinants in shaping offspring's microbiome in the first 1000 days: study protocol and preliminary results at one month of life.Italian journal of pediatrics · 2020Observational
- Association between Bioactive Molecules in Breast Milk and Type 1 Diabetes Mellitus.Sultan Qaboos University medical journal · 2020Review
- Nutritional Interventions in Cancer Cachexia: Evidence and Perspectives From Experimental Models.Frontiers in nutrition · 2020Review
- Early Nutrition and Risk of Type 1 Diabetes: The Role of Gut Microbiota.Frontiers in nutrition · 2020Review
- Human milk oligosaccharides promote immune tolerance via direct interactions with human dendritic cells.European journal of immunology · 2019Article
- Factors influencing the gut microbiome in children: from infancy to childhood.Journal of biosciences · 2019Review
- Probiotics and Prebiotics for the Amelioration of Type 1 Diabetes: Present and Future Perspectives.Microorganisms · 2019Review
- The Roles of Peyer's Patches and Microfold Cells in the Gut Immune System: Relevance to Autoimmune Diseases.Frontiers in immunology · 2019Review
- Lifestyle Factors Affecting the Gut Microbiota's Relationship with Type 1 Diabetes.Current diabetes reports · 2018Review
- Human milk oligosaccharides protect against the development of autoimmune diabetes in NOD-mice.Scientific reports · 2018Article
- Supplementation With 2'-FL and scGOS/lcFOS Ameliorates Rotavirus-Induced Diarrhea in Suckling Rats.Frontiers in cellular and infection microbiology · 2018Article
- Immunological Effects of Human Milk Oligosaccharides.Frontiers in pediatrics · 2018Review
- Human Milk Oligosaccharide 2'-Fucosyllactose Improves Innate and Adaptive Immunity in an Influenza-Specific Murine Vaccination Model.Frontiers in immunology · 2018Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Type 1 diabetes (T1D) is an immune-mediated disease with a strong genetic basis but might be influenced by non-genetic factors such as microbiome development that "programs" the immune system during early life as well. Factors influencing pathogenesis, including a leaky intestinal mucosal barrier, an aberrant gut microbiota composition, and altered immune responsiveness, offer potential targets for prevention and/or treatment of T1D through nutritional or pharmacologic means. In this review, nutritional approaches during early life in order to protect against T1D development have been discussed. The critical role of tolerogenic dendritic cells in central and peripheral tolerance has been emphasized. In addition, since the gut microbiota affects the development of T1D through short-chain fatty acid (SCFA)-dependent mechanisms, we hypothesize that nutritional intervention boosting SCFA production may be used as a novel prevention strategy. Current retrospective evidence has suggested that exclusive and prolonged breastfeeding might play a protective role against the development of T1D. The beneficial properties of human milk are possibly attributed to its bioactive components such as unique immune-modulatory components human milk oligosaccharides and metabolites derived thereof, including SCFAs. These components might play a key role in healthy immune development and creating a fit and resilient immune system in early and later life.
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