ArticleFrontiers in endocrinology2017
The Influence of a KDT501, a Novel Isohumulone, on Adipocyte Function in Humans.
Article in Frontiers in endocrinology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02444910 (Effects of KDT501 on Metabolic Features in Insulin Resistant Subjects), which is not on this map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of KDT501 on Metabolic Features in Insulin Resistant Subjects
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- The Promising Ability ofMolecules (Basel, Switzerland) · 2021Pooled it
- Adipose Tissue Mast Cells Promote Human Adipose Beiging in Response to Cold.Scientific reports · 2019Trial
- Enantioselectivity of Isomerization ofMolecules (Basel, Switzerland) · 2026Article
- Review
- Potential Therapeutic Exploitation of G Protein-Coupled Receptor 120 (GPR120/FFAR4) Signaling in Obesity-Related Metabolic Disorders.International journal of molecular sciences · 2025Review
- Continuous-Flow Photochemical Isomerization of Humulones to Isohumulones.Molecules (Basel, Switzerland) · 2025Article
- Macrophages expressing uncoupling protein 1 increase in adipose tissue in response to cold in humans.Scientific reports · 2021Article
- Application of Phytochemicals in Immune Disorders: Their Roles Beyond Antioxidants.Integrative medicine (Encinitas, Calif.) · 2021Article
- Development of Free Fatty Acid Receptor 4 (FFA4/GPR120) Agonists in Health Science.Biomolecules & therapeutics · 2021Review
- The Opportunities and Challenges of Peroxisome Proliferator-Activated Receptors Ligands in Clinical Drug Discovery and Development.International journal of molecular sciences · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveIn a phase II clinical trial in nine obese, insulin-resistant humans, we observed that treatment with KDT501, a novel isohumulone drug, increased total and high-molecular weight (HMW) adiponectin in plasma. The objective was to determine whether KDT501 increased adiponectin secretion from subcutaneous white adipose tissue (SC WAT) and the underlying mechanism(s).
methodsNine obese participants with either prediabetes or with normal glucose tolerance plus three features of metabolic syndrome were part of the study. SC WAT biopsies were performed before and after 28 days of KDT501 treatment in a clinical research setting. In addition, a cold stimulus was used to induce thermogenic gene expression. Adiponectin secretion was measured, and gene expression of 130 genes involved in adipose tissue function was determined. The effect of KDT501 on adipocyte mitochondrial function was analyzed
resultsSC WAT explants secreted more total and HMW adiponectin after KDT501 treatment (
conclusionKDT501 induced adiponectin secretion posttranscriptionally and increased gene expression of thermogenic and lipolytic genes in response to cold stimulation. These beneficial effects on SC WAT may be explained by the ability of KDT501 to potentiate β-adrenergic signaling and enhance mitochondrial function in adipocytes. CLINICAL
trial registrationhttps://www.ClinicalTrials.gov, ID number: NCT02444910.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.