ReviewFrontiers in neurology2017
Concussion As a Multi-Scale Complex System: An Interdisciplinary Synthesis of Current Knowledge.
Review in Frontiers in neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A Systematic Review of ASL Perfusion MRI in Mild TBI.Neuropsychology review · 2023Pooled it
- Subtypes of Sport-Related Concussion: a Systematic Review and Meta-cluster Analysis.Sports medicine (Auckland, N.Z.) · 2020Pooled it
- A proposed organization of multifaceted knowledge in data repositories: structuring record collections and evidence sets for data lakehouses and moonshots.Journal of exposure science & environmental epidemiology · 2026Review
- Cognitive Outcomes Following Paediatric Mild Traumatic Brain Injury: A Systematic Review and Meta-Analysis of Studies up to 2025.Neuropsychology review · 2026Review
- Impact frequency and interval modulate brain network outcomes in a rat model of repetitive mild traumatic brain injury.Scientific reports · 2026Article
- Article
- The Influence of Aerobic Exercise Therapy on Patient-Reported Outcome Measures Following Concussion: A Scoping Review.Biomedicines · 2025Review
- How Are TBI Symptoms Interconnected? A Network Analysis Approach.Brain and behavior · 2025Article
- The NERD model: reflex circuit dysfunction as a systems-level driver of persistent post-concussion symptoms.Frontiers in systems neuroscience · 2025Article
- Postconcussive symptom severity, risk factors for prolonged recovery, and mental health history: Pathways of influence in a diverse pediatric sample.Annals of the Child Neurology Society · 2024Article
- Perceptual Response Training for Reduction of Injury Risk Among High School Girls' Soccer Players.Brain sciences · 2024Article
- Outcome measures used in adolescent sport-related concussion research: a scoping review.BMJ open · 2024Article
- Persistent MRI Findings Unique to Blast and Repetitive Mild TBI: Analysis of the CENC/LIMBIC Cohort Injury Characteristics.Military medicine · 2024Observational
- National Athletic Trainers' Association Bridge Statement: Management of Sport-Related Concussion.Journal of athletic training · 2024Article
- Exercise Intolerance After Mild Traumatic Brain Injury Occurs in All Subtypes in the Adult Population.Journal of neurotrauma · 2024Article
- Applying Dynamical Systems Theory to Improve Personalized Medicine Following Mild Traumatic Brain Injury.Neurotrauma reports · 2024Article
- The role of the physiotherapist in concussion.The South African journal of physiotherapy · 2024Article
- Elucidating a genomic signature associated with behavioral and executive function after moderate to severe pediatric TBI: a systems biology informed approach.Frontiers in systems biology · 2024Article
- Prolonged Disability following Re-Exposure after Complete Recovery from Aerotoxic Syndrome: A Case Report.International journal of environmental research and public health · 2023Article
- Factors related to adverse long-term outcomes after mild traumatic brain injury in children: a scoping review.Archives of disease in childhood · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Traumatic brain injury (TBI) has been called "the most complicated disease of the most complex organ of the body" and is an increasingly high-profile public health issue. Many patients report long-term impairments following even "mild" injuries, but reliable criteria for diagnosis and prognosis are lacking. Every clinical trial for TBI treatment to date has failed to demonstrate reliable and safe improvement in outcomes, and the existing body of literature is insufficient to support the creation of a new classification system. Concussion, or mild TBI, is a highly heterogeneous phenomenon, and numerous factors interact dynamically to influence an individual's recovery trajectory. Many of the obstacles faced in research and clinical practice related to TBI and concussion, including observed heterogeneity, arguably stem from the complexity of the condition itself. To improve understanding of this complexity, we review the current state of research through the lens provided by the interdisciplinary field of systems science, which has been increasingly applied to biomedical issues. The review was conducted iteratively, through multiple phases of literature review, expert interviews, and systems diagramming and represents the first phase in an effort to develop systems models of concussion. The primary focus of this work was to examine concepts and ways of thinking about concussion that currently impede research design and block advancements in care of TBI. Results are presented in the form of a multi-scale conceptual framework intended to synthesize knowledge across disciplines, improve research design, and provide a broader, multi-scale model for understanding concussion pathophysiology, classification, and treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.