ReviewFrontiers in psychiatry2017
Olfactory Functioning and Depression: A Systematic Review.
Review in Frontiers in psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic narrative review of the form, process, and function of sensory hyposensitivity in depression.Translational psychiatry · 2026Pooled it
- Psychosocial Factors Mediate the Relationship Between Olfactory Function and Cognitive Frailty in Older Adults: A Structural Equation Modelling.Australasian journal on ageing · 2026Article
- APOE ε4 carriage is associated with olfactory-hippocampal tract functional connectivity.Brain imaging and behavior · 2026Article
- Secondary analysis of GenRED data (Genetics of Recurrent Early-Onset major Depression) using MERLIN.European archives of psychiatry and clinical neuroscience · 2026Article
- Impaired olfactory function in substance use disorder.Psychopharmacology · 2025Article
- Pre-pandemic disease trajectories and genetic insights into long COVID susceptibility.BMC medicine · 2025Article
- IMPAIRED OLFACTORY FUNCTION IN SUBSTANCE USE DISORDER.medRxiv : the preprint server for health sciences · 2025Article
- Scenting the Hedonic Connection: Exploring the Impact of Subjective Olfactory Dysfunction on Depressive Symptoms.PsyCh journal · 2025Article
- Novel Gene-Informed Regional Brain Targets for Clinical Screening for Major Depression.Neurology international · 2025Article
- Odor-enhanced Visual Processing in PTSD.NeuroImage · 2025Article
- Article
- The olfactory diary: Tracking awareness and consciousness of the sense of smell throughout the day.Laryngoscope investigative otolaryngology · 2024Article
- The relationship of personality, alexithymia, anxiety symptoms, and odor awareness: a mediation analysis.BMC psychiatry · 2024Article
- Olfactory neurofeedback: current state and possibilities for further development.Frontiers in human neuroscience · 2024Article
- Olfactory brain activations in patients with Major Depressive Disorder.Scientific reports · 2023Article
- Olfactory dysfunction as a common biomarker for neurodegenerative and neuropsychiatric disorders.Neural regeneration research · 2023Article
- Olfactory Dysfunction in Mental Illness.Current allergy and asthma reports · 2023Review
- Association between chemosensory impairment with neuropsychiatric morbidity in post-acute COVID-19 syndrome: results from a multidisciplinary cohort study.European archives of psychiatry and clinical neuroscience · 2023Article
- Neurons, Nose, and Neurodegenerative Diseases: Olfactory Function and Cognitive Impairment.International journal of molecular sciences · 2023Review
- Chronic unpredictable mild stress alters odor hedonics and adult olfactory neurogenesis in mice.Frontiers in neuroscience · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundResearch has demonstrated a reduction in olfactory functioning in patients with schizophrenia. This research has led to examination of olfactory functioning in other mental disorders, such as depression. There is a great deal of variation in the results generated from such research, and it remains unclear as to how olfactory functioning is associated with or impacted by depression.
methodThe current review examined the literature in accordance with PRISMA guidelines in order to generate a better understanding of this relationship and to identify if and what aspects of olfactory processing are altered. Through examination of the available literature from the databases PubMed, Ovid Medline, CINAL, and PsychINFO, 15 manuscripts were selected to determine if there was a difference in olfactory processing-specifically central and peripheral processing-between depressed individuals and non-depressed controls.
resultsThe comparison of the 15 studies showed that the majority of studies (9/15, 60%) found a difference in overall olfactory functioning between depressed individuals and non-depressed controls ( LIMITATIONS: There is still a lack of definitive conclusions due to variation of which olfactory process was altered.
conclusionGiven the differences in the methodology and design of these studies, a possible solution that could eliminate the lack of clarity and reduce variation would be to adhere to a single, thorough methodology that examines and separates central and peripheral olfactory processing. Future research employing a uniform and validated methodology could provide more definitive conclusions as to how and if olfactory functioning is related depression.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.