ArticleFrontiers in human neuroscience2017
Is Congenital Amusia a Disconnection Syndrome? A Study Combining Tract- and Network-Based Analysis.
Article in Frontiers in human neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- Splenial lesions of the corpus callosum: a comprehensive study on etiology, clinical presentation, radiological features, and prognostic insights.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Review
- The neuroscience of music perception: a narrative review.Arquivos de neuro-psiquiatria · 2025Review
- Elevated Activity in Left Homologous Music Circuits Is Inhibitory for Music Perception but Mediated by Structure-Function Coupling.CNS neuroscience & therapeutics · 2024Article
- Common neural substrates of diverse neurodevelopmental disorders.Brain : a journal of neurology · 2023Article
- Lateral prefrontal cortex is a hub for music production from structural rules to movements.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Congenital amusia-pathology of musical disorder.Journal of applied genetics · 2022Review
- Changes in sensorimotor regions of the cerebral cortex in congenital amusia: a case-control study.Neural regeneration research · 2021Article
- Increased Resting-State Interhemispheric Functional Connectivity of Posterior Superior Temporal Gyrus and Posterior Cingulate Cortex in Congenital Amusia.Frontiers in neuroscience · 2021Article
- Cortical Morphological Changes in Congenital Amusia: Surface-Based Analyses.Frontiers in psychiatry · 2021Article
- Dichotic Perception of Lexical Tones in Cantonese-Speaking Congenital Amusics.Frontiers in psychology · 2020Article
- White Matter Microstructure Reflects Individual Differences in Music Reward Sensitivity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Talker normalization in typical Cantonese-speaking listeners and congenital amusics: Evidence from event-related potentials.NeuroImage. Clinical · 2019Article
- Normal pre-attentive and impaired attentive processing of lexical tones in Cantonese-speaking congenital amusics.Scientific reports · 2018Article
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies on congenital amusia mainly focused on the impaired fronto-temporal pathway. It is possible that neural pathways of amusia patients on a larger scale are affected. In this study, we investigated changes in structural connections by applying both tract-based and network-based analysis to DTI data of 12 subjects with congenital amusia and 20 demographic-matched normal controls. TBSS (tract-based spatial statistics) was used to detect microstructural changes. The results showed that amusics had higher diffusivity indices in the corpus callosum, the right inferior/superior longitudinal fasciculus, and the right inferior frontal-occipital fasciculus (IFOF). The axial diffusivity values of the right IFOF were negatively correlated with musical scores in the amusia group. Network-based analysis showed that the efficiency of the brain network was reduced in amusics. The impairments of WM tracts were also found to be correlated with reduced network efficiency in amusics. This suggests that impaired WM tracts may lead to the reduced network efficiency seen in amusics. Our findings suggest that congenital amusia is a disconnection syndrome.
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