ArticleDevelopmental cell2017
Binding of PLD2-Generated Phosphatidic Acid to KIF5B Promotes MT1-MMP Surface Trafficking and Lung Metastasis of Mouse Breast Cancer Cells.
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Article in Developmental cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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43 citing papers in PubMed, 74 citations in OpenAlex.
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- Quantification of Spatial Patterns of Microtubule Transport by Kinesin-1 Head and Tail.Bio-protocol · 2026Article
- Selective targeting of kinesin on lipid droplets in the liver reduces plasma lipids.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Phospholipase D: emerging therapeutic targets in signaling, metabolism, and immune-oncology.Cell communication and signaling : CCS · 2025Review
- Enzalutamide-Resistant STEAP4Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- The tail domain of the plant kinesin-12 POK2 is a versatile interaction hub.Journal of cell science · 2025Article
- Phosphatidic acid-dependent recruitment of microtubule motors to spherical supported lipid bilayers for in vitro motility assays.Cell reports · 2024Article
- Lipidome analyses reveal radiation induced remodeling of glycerophospholipid unsaturation in lung tumor.Frontiers in immunology · 2024Article
- USP22 overexpression fails to augment tumor formation in MMTV-ERBB2 mice but loss of function impacts MMTV promoter activity.PloS one · 2024Article
- Lipopolysaccharide Stimulates A549 Cell Migration through p-Tyr 42 RhoA and Phospholipase D1 Activity.Biomolecules · 2023Article
- Upregulated phospholipase D2 expression and activity is related to the metastatic properties of melanoma.Oncology letters · 2022Article
- Interactome Analysis of Human Phospholipase D and Phosphatidic Acid-Associated Protein Network.Molecular & cellular proteomics : MCP · 2022Article
- Microtubule motor driven interactions of lipid droplets: Specificities and opportunities.Frontiers in cell and developmental biology · 2022Review
- PLD1 promotes reactive oxygen species production in vascular smooth muscle cells and injury-induced neointima formation.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2022Article
- CircKIF5B Promotes Hepatocellular Carcinoma Progression by Regulating the miR-192 Family/XIAP Axis.Frontiers in oncology · 2022Article
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- Transcriptional landscape associated with TNBC resistance to neoadjuvant chemotherapy revealed by single-cell RNA-seq.Molecular therapy oncolytics · 2021Article
- Molecular mechanism for kinesin-1 direct membrane recognition.Science advances · 2021Article
- Msi1 promotes breast cancer metastasis by regulating invadopodia-mediated extracellular matrix degradation via the Timp3-Mmp9 pathway.Oncogene · 2021Article
- Phospholipase Signaling in Breast Cancer.Advances in experimental medicine and biology · 2021Review
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Authors and funding
15 authors at 5 institutions in 2 countries.
Ziqing WangDepartment of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston, 6431 Fannin St., Houston, TX 77030, USA.
Feng ZhangDepartment of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston, 6431 Fannin St., Houston, TX 77030, USA; Core Facility, Department of Clinical Laboratory, Quzhou People's Hospital, Quzhou, Zhejiang, China.
Jingquan HeDepartment of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston, 6431 Fannin St., Houston, TX 77030, USA.
Ping WuDepartment of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston, 6431 Fannin St., Houston, TX 77030, USA.
Li Wei Rachel TayDepartment of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston, 6431 Fannin St., Houston, TX 77030, USA.
Ming CaiDepartment of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston, 6431 Fannin St., Houston, TX 77030, USA; Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province 430022, China.
Weiqi NianDepartment of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston, 6431 Fannin St., Houston, TX 77030, USA; Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing Cancer Hospital & Institute & Cancer Center, Chongqing 400030, China.
Yuanyuan WengCore Facility, Department of Clinical Laboratory, Quzhou People's Hospital, Quzhou, Zhejiang, China.
Li QinDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
Jeffrey T ChangDepartment of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston, 6431 Fannin St., Houston, TX 77030, USA.
Laura B McIntireDepartment of Pathology and Cell Biology, Columbia University Medical Center, New York, NY 10032, USA.
Gilbert Di PaoloDepartment of Pathology and Cell Biology, Columbia University Medical Center, New York, NY 10032, USA.
Jianming XuDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
Junmin PengDepartments of Structural Biology and Developmental Neurobiology, St. Jude Proteomics Facility, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Guangwei DuDepartment of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston, 6431 Fannin St., Houston, TX 77030, USA. Electronic address: guangwei.du@uth.tmc.edu.
The University of Texas Health Science Center at Houston · USBaylor College of Medicine · USColumbia University Irving Medical Center · USQuzhou City People's Hospital · CNSt. Jude Children's Research Hospital · US
Funding
Role of phospholipids in membrane traffic at the synapseR01NS056049 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LIEM, RONALD K. · 2006 to 2016
$3.7MThe Role of SRC-1 in Breast CancerR01CA112403 · NCI · BAYLOR COLLEGE OF MEDICINE · PI XU, JIANMING · 2006 to 2016
$2.9MMulti-level Integrative Proteomics to Alzheimer's Disease PathwaysR01AG053987 · NIA · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI PENG, JUNMIN · 2016 to 2020
$2.2MNCOA6, A Novel Tumor Suppressor of Endometrial CancerR01CA193455 · NCI · BAYLOR COLLEGE OF MEDICINE · PI XU, JIANMING · 2016 to 2021
$1.9MPhospholipase D2 regulation of vascular smooth muscle cell migrationR01HL119478 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI DU, GUANGWEI · 2014 to 2017
$1.5MProteomics Approaches to Protein TurnoverR01GM114260 · NIGMS · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI PENG, JUNMIN · 2016 to 2019
$1.4MNCI NIH HHS R01 CA112403NCI NIH HHS R01 CA193455NHLBI NIH HHS R01 HL119478NIA NIH HHS R01 AG053987NIGMS NIH HHS R01 GM114260NINDS NIH HHS R01 NS056049
Abstract
Little is known about the cellular events promoting metastasis. We show that knockout of phospholipase D
Indexed as
AnimalsCell MembraneCell MovementFemaleHumansKinesinsLung NeoplasmsMammary Neoplasms, AnimalMatrix Metalloproteinase 14MCF-7 CellsMiceMice, Inbred C57BLMice, KnockoutPhosphatidic AcidsPhospholipase DProtein BindingKif5b protein, mouseKinesinsMatrix Metalloproteinase 14Phosphatidic AcidsPhospholipase Dphospholipase D2breast cancerinvadopodiaKIF5BmetastasisMT1-MMPphosphatidic acidphospholipase DPLDPLD2
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.