Evidence map›Paper›PMID 29033353›Full record

ArticleCell stem cell2017

Melanocyte Stem Cell Activation and Translocation Initiate Cutaneous Melanoma in Response to UV Exposure.

Hyeongsun Moon, Leanne R Donahue, Eunju Choi, Philip O Scumpia, William E Lowry, Jennifer K Grenier, Jerry Zhu, Andrew C White

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell stem cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 122 citations in OpenAlex.

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  8. Generation of theInternational journal of molecular sciences · 2025
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  10. Dangerous liaisons: Loss of keratinocyte control over melanocytes in melanomagenesis.BioEssays : news and reviews in molecular, cellular and developmental biology · 2024
    Review
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11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Hyeongsun MoonDepartment of Biomedical Sciences, Cornell University, Ithaca, NY 14853, USA.
Leanne R DonahueDepartment of Biomedical Sciences, Cornell University, Ithaca, NY 14853, USA.
Eunju ChoiDepartment of Biomedical Sciences, Cornell University, Ithaca, NY 14853, USA.
Philip O ScumpiaDepartment of Medicine, Division of Dermatology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
William E LowryDepartment of Molecular Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Jennifer K GrenierDepartment of Biomedical Sciences, Cornell University, Ithaca, NY 14853, USA.
Jerry ZhuDepartment of Biomedical Sciences, Cornell University, Ithaca, NY 14853, USA.
Andrew C WhiteDepartment of Biomedical Sciences, Cornell University, Ithaca, NY 14853, USA. Electronic address: acw93@cornell.edu.
Cornell University · USUniversity of California, Los Angeles · US

Funding

Metabolic Control of Hair Follicle Stem Cell Homeostasis and TumorigenesisR01AR070245 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHRISTOFK, HEATHER, LOWRY, WILLIAM E · 2018 to 2022
$2.1M
Identification and characterization of cancer cells of origin in the epidermisR01AR057409 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LOWRY, WILLIAM E · 2010 to 2014
$1.7M
NIAMS NIH HHS R01 AR057409NIAMS NIH HHS R01 AR070245
6 · The paper itself

Abstract

Melanoma is one of the deadliest cancers, yet the cells of origin and mechanisms of tumor initiation remain unclear. The majority of melanomas emerge from clear skin without a precursor lesion, but it is unknown whether these melanomas can arise from melanocyte stem cells (MCSCs). Here we employ mouse models to define the role of MCSCs as melanoma cells of origin, demonstrate that MCSC quiescence acts as a tumor suppressor, and identify the extrinsic environmental and molecular factors required for the critical early steps of melanoma initiation. Specifically, melanomas originate from melanoma-competent MCSCs upon stimulation by UVB, which induces MCSC activation and translocation via an inflammation-dependent process. Moreover, the chromatin-remodeling factor Hmga2 in the skin plays a critical role in UVB-mediated melanomagenesis. These findings delineate melanoma formation from melanoma-competent MCSCs following extrinsic stimuli, and they suggest that abrogation of Hmga2 function in the microenvironment can suppress MCSC-originating cutaneous melanomas.

Indexed as

Ultraviolet RaysAnimalsCarcinogenesisCutaneous Malignant MelanomaGene Expression ProfilingGene Expression Regulation, NeoplasticHairInflammationIntegrasesMelanocytesMelanomaMiceOncogenesSkinSkin NeoplasmsStaining and LabelingCre recombinaseIntegrasesSunscreening AgentsHmga2melanocyte stem cellmelanomaultraviolet radiation

Identifiers

PMID29033353
PMCPMC9004284
OpenAlexW2764295362

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.