Evidence map›Paper›PMID 29033061›Full record

Observational studyOphthalmology2018

Predicting Vision-Related Disability in Glaucoma.

Ricardo Y Abe, Alberto Diniz-Filho, Vital P Costa, Zhichao Wu, Felipe A Medeiros

Open access · greenAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Ophthalmology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Observational
  3. Article
  4. Article
  5. Article
  6. [Review of studies on the application of biomechanical factors in the evaluation of glaucoma].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2019
    Review
  7. Article
  8. Article
  9. Observational
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Ricardo Y AbeDepartment of Ophthalmology, Duke University, Durham, North Carolina; Department of Ophthalmology, University of California, San Diego, La Jolla, California; Department of Ophthalmology, University of Campinas, Campinas, Brazil.
Alberto Diniz-FilhoDepartment of Ophthalmology, University of California, San Diego, La Jolla, California.
Vital P CostaDepartment of Ophthalmology, University of Campinas, Campinas, Brazil.
Zhichao WuDepartment of Ophthalmology, University of California, San Diego, La Jolla, California.
Felipe A MedeirosDepartment of Ophthalmology, Duke University, Durham, North Carolina; Department of Ophthalmology, University of California, San Diego, La Jolla, California. Electronic address: felipe.medeiros@duke.edu.
Duke University · USUniversity of California San Diego · USUniversidade Estadual de Campinas (UNICAMP) · BR

Funding

Diagnostic Innovations in Glaucoma Study (DIGS): Functional ImpairmentR01EY021818 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MEDEIROS, FELIPE · 2011 to 2015
$3.4M
NEI NIH HHS R01 EY021818
6 · The paper itself

Abstract

purposeTo present a new methodology for investigating predictive factors associated with development of vision-related disability in glaucoma.

designProspective, observational cohort study.

participantsTwo hundred thirty-six patients with glaucoma followed up for an average of 4.3±1.5 years.

methodsVision-related disability was assessed by the 25-item National Eye Institute Visual Function Questionnaire (NEI VFQ-25) at baseline and at the end of follow-up. A latent transition analysis model was used to categorize NEI VFQ-25 results and to estimate the probability of developing vision-related disability during follow-up. Patients were tested with standard automated perimetry (SAP) at 6-month intervals, and evaluation of rates of visual field change was performed using mean sensitivity (MS) of the integrated binocular visual field. Baseline disease severity, rate of visual field loss, and duration of follow-up were investigated as predictive factors for development of disability during follow-up.

main outcome measuresThe relationship between baseline and rates of visual field deterioration and the probability of vision-related disability developing during follow-up.

resultsAt baseline, 67 of 236 (28%) glaucoma patients were classified as disabled based on NEI VFQ-25 results, whereas 169 (72%) were classified as nondisabled. Patients classified as nondisabled at baseline had 14.2% probability of disability developing during follow-up. Rates of visual field loss as estimated by integrated binocular MS were almost 4 times faster for those in whom disability developed versus those in whom it did not (-0.78±1.00 dB/year vs. -0.20±0.47 dB/year, respectively; P < 0.001). In the multivariate model, each 1-dB lower baseline binocular MS was associated with 34% higher odds of disability developing over time (odds ratio [OR], 1.34; 95% confidence interval [CI], 1.06-1.70; P = 0.013). In addition, each 0.5-dB/year faster rate of loss of binocular MS during follow-up was associated with a more than 3.5 times increase in the risk of disability developing (OR, 3.58; 95% CI, 1.56-8.23; P = 0.003).

conclusionsA new methodology for classification and analysis of change in patient-reported quality-of-life outcomes allowed construction of models for predicting vision-related disability in glaucoma.

Indexed as

Disability EvaluationQuality of LifeAgedFemaleFollow-Up StudiesGlaucomaHumansIntraocular PressureMalePersons with DisabilitiesProspective StudiesSurveys and QuestionnairesTime FactorsVision, BinocularVisual FieldsVisual Field Tests

Identifiers

PMID29033061
PMCPMC6882428
OpenAlexW2760997812

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.