ArticleJournal of the International Neuropsychological Society : JINS2018
Symptom Dimensions of Depression and Apathy and Their Relationship With Cognition in Parkinson's Disease.
Article in Journal of the International Neuropsychological Society : JINS, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- The impact of impulse control disorders on cognitive decline inFrontiers in neurology · 2025Article
- Neurocognitive Impairment and Social Cognition in Parkinson's Disease Patients.Neurology international · 2024Review
- Synergistic associations of depressive symptoms and aging on cognitive decline in early Parkinson's disease.Clinical parkinsonism & related disorders · 2023Article
- The indirect relationship between sleep and cognition in the PREVENT cohort: identifying targets for intervention.Frontiers in sleep · 2023Article
- Differential contributions of depression, apathy, and anxiety to neuropsychological performance in Parkinson's disease versus essential tremor.Journal of clinical and experimental neuropsychology · 2022Article
- Physical inactivity links depressive symptoms and cognitive functioning among individuals with Parkinson's disease.Neuropsychology · 2022Article
- Apathy as a Within-Person Mediator of Depressive Symptoms and Cognition in Parkinson's Disease: Longitudinal Mediation Analyses.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2022Article
- The impact of poor medication knowledge on health-related quality of life in people with Parkinson's disease: a mediation analysis.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2022Article
- Depressive symptom profiles predict dementia onset and brain pathology in older persons. The AGES-Reykjavik study.Neurobiology of aging · 2022Article
- Statistically Defined Parkinson's Disease Executive and Memory Cognitive Phenotypes: Demographic, Behavioral, and Structural Neuroimaging Comparisons.Journal of Parkinson's disease · 2021Article
- Greater intraindividual variability in neuropsychological performance predicts cognitive impairment in de novo Parkinson's disease.Neuropsychology · 2020Article
- Depressive symptoms precede cognitive impairment in de novo Parkinson's disease patients: Analysis of the PPMI cohort.Neuropsychology · 2019Article
- Psychometric Properties of the Apathy Scale in Advanced Parkinson's Disease.Parkinson's disease · 2019Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
objectivesBoth depression and apathy, alone and in combination, have been shown to negatively affect cognition in patients with Parkinson's disease (PD). However, the influence of specific symptom dimensions of depression and apathy on cognition is not well understood. The current study investigated the relationship between symptom dimensions of depression and apathy, based on factors identified in Kirsch-Darrow et al. (2011), and memory and executive function in PD.
methodsA sample of 138 non-demented individuals with PD (mean age=64.51±7.43 years) underwent neuropsychological testing and completed the Beck Depression Inventory, 2nd Edition, and Apathy Scale. Separate hierarchical regression models examined the relationship between symptom dimensions of depression and apathy ("pure" depressive symptoms, "pure" apathy, loss of interest/pleasure [anhedonia], and somatic symptoms) and three cognitive domain composites: immediate verbal memory, delayed verbal memory, and executive function.
resultsAfter adjusting for general cognitive status and the influence of the other symptom dimensions, "pure" depressive symptoms were negatively associated with the delayed verbal memory composite (p<.034) and somatic symptoms were positively associated with the executive function composite (p<.026). No symptom dimensions were significantly related to the immediate verbal memory composite.
conclusionsFindings suggest that specific mood symptoms are associated with delayed verbal memory and executive function performance in non-demented patients with PD. Further research is needed to better understand possible mechanisms through which specific symptom dimensions of depression and apathy are associated with cognition in PD. (JINS, 2018, 24, 269-282).
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