Evidence map›Paper›PMID 29032643›Full record

ArticleJournal of microbiology and biotechnology2017

Effects of Extended Storage of Chlorhexidine Gluconate and Benzalkonium Chloride Solutions on the Viability of Burkholderia cenocepacia.

Youngbeom Ahn, Jeong Myeong Kim, Yong-Jin Lee, John LiPuma, David Hussong, Bernard Marasa, Carl Cerniglia

Abstract read
In one paragraph

Article in Journal of microbiology and biotechnology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Clinical microbiology reviews · 2020
    Review
  7. Adaptation and Survival ofFrontiers in bioengineering and biotechnology · 2020
    Article
  8. Article
  9. Review
  10. Outbreak ofEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Youngbeom AhnDivision of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA.
Jeong Myeong KimDivision of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA.
Yong-Jin LeeDepartment of Biological Sciences, Albany State University, Albany, GA 31707, USA.
John LiPumaDepartment of Pediatrics & Communicable Diseases, University of Michigan, Ann Arbor, MI 48109, USA.
David HussongValSource, LLC., Downingtown, PA 19335, USA.
Bernard MarasaOffice of Pharmaceutical Quality, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD 20993, USA.
Carl CernigliaDivision of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA.

Funding

Intramural FDA HHS FD999999
6 · The paper itself

Abstract

Chlorhexidine gluconate (CHX) and benzalkonium chloride (BZK) formulations are frequently used as antiseptics in healthcare and consumer products. Burkholderia cepacia complex (BCC) contamination of pharmaceutical products could be due to the use of contaminated water in the manufacturing process, over-diluted antiseptic solutions in the product, and the use of outdated products, which in turn reduces the antimicrobial activity of CHX and BZK. To establish a "safe use" period following opening containers of CHX and BZK, we measured the antimicrobial effects of CHX (2-10 μg/ml) and BZK (10-50 μg/ml) at sublethal concentrations on six strains of

Indexed as

Anti-Infective Agents, LocalBenzalkonium CompoundsBurkholderia cenocepaciaChlorhexidineMicrobial ViabilityAnti-Infective Agents, LocalBenzalkonium CompoundsChlorhexidinechlorhexidine gluconateantisepticBactericidal effectsbenzalkonium chlorideBurkholderia cenocepaciachlorhexidine gluconate

Identifiers

PMID29032643
PMCPMC12392026

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.