Evidence map›Paper›PMID 29032601›Full record

ArticleClinical transplantation2017

Persistent regional and racial disparities in nondirected living kidney donation.

Komal Kumar, Courtenay M Holscher, Xun Luo, Jacqueline Garonzik Wang, Saad Anjum, Elizabeth A King, Allan B Massie, James M Tonascia, Tanjala S Purnell, Dorry L Segev

Abstract read
In one paragraph

Article in Clinical transplantation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. The benefit to waitlist patients in a national paired kidney exchange program: Exploring characteristics of chain end living donor transplants.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2022
    Article
  4. Article
  5. Temporal changes in the composition of a large multicenter kidney exchange clearinghouse: Do the hard-to-match accumulate?American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2018
    Article
  6. Article
  7. Trends over Time in Practice and Outcomes of Lung Transplantation in Recipients With Human Immunodeficiency Virus.Transplant infectious disease : an official journal of the Transplantation Society
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Komal KumarDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Courtenay M HolscherDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-5808-5954
Xun LuoDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jacqueline Garonzik WangDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Saad AnjumDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Elizabeth A KingDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Allan B MassieDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
James M TonasciaDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Tanjala S PurnellDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Dorry L SegevDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Funding

Long-Term Health Outcomes After Live Kidney Donation in African AmericansR01DK096008 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SEGEV, DORRY L. · 2013 to 2017
$3.8M
Patient Oriented Research in Kidney Disease and Transplant SurgeryK24DK101828 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SEGEV, DORRY L. · 2014 to 2018
$922k
Determinants of chronic kidney disease in African-American live kidney donorsK01DK101677 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI MASSIE, ALLAN B · 2015 to 2019
$789k
Patient-Centered Strategies to Reduce Disparities in Access to Kidney TransplantationK01HS024600 · AHRQ · JOHNS HOPKINS UNIVERSITY · PI PURNELL, TANJALA · 2016 to 2020
$786k
Trajectory of post-donation renal function in living kidney donorsF32DK109662 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI HOLSCHER, COURTENAY · 2016 to 2018
$232k
AHRQ HHS K01 HS024600NIDDK NIH HHS F32 DK109662NIDDK NIH HHS K01 DK101677NIDDK NIH HHS K24 DK101828NIDDK NIH HHS R01 DK096008
6 · The paper itself

Abstract

Nondirected living donors (NDLDs) are an important and growing source of kidneys to help reduce the organ shortage. In its infancy, NDLD transplantation was clustered at a few transplant centers and rarely benefited African American (AA) recipients. However, NDLDs have increased 9.4-fold since 2000, and now are often used to initiate kidney paired donation chains. Therefore, we hypothesized that the initial geographic clustering and racial disparities may have improved. We used Scientific Registry of Transplant Recipients data to compare NDLDs and their recipients between 2008-2015 and 2000-2007. We found that NDLD increased an average of 12% per year, from 20 in 2000 to 188 in 2015 (IRR: 1.12, 95% CI: 1.11-1.13, P < .001). In 2000-2007, 18.3% of recipients of NDLD kidneys were AA; this decreased in 2008-2015 to 15.7%. NDLD transplants initially became more evenly distributed across centers (Gini 0.91 in 2000 to Gini 0.69 in 2011), but then became more clustered at fewer transplant centers (Gini 0.75 in 2015). Despite the increased number of NDLDs, racial disparities have worsened and the center-level distribution of NDLD transplants has narrowed in recent years.

Indexed as

Healthcare DisparitiesRacial GroupsAdultFemaleFollow-Up StudiesGeographyHistocompatibility TestingHumansKidney Failure, ChronicKidney TransplantationLiving DonorsMaleMiddle AgedPrognosisRegistriesTissue and Organ Procurementkidney allocationliving donationliving donor transplantationnondirected donors

Identifiers

PMID29032601
PMCPMC5863752

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.