Characterization of Borrelia burgdorferi Binding to Mammalian Cells and Extracellular Matrix.

Yi-Pin Lin, John M Leong

Abstract read

In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact, top 86% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

Visualization of the Dynamics of Invasion and Intravasation of the Bacterium That Causes Lyme Disease in a Tissue Engineered Dermal Microvessel Model.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Yi-Pin LinDivision of Infectious Disease, Wadsworth Center, New York State Department of Health, 120 New Scotland Ave., Albany, NY, 12208, USA. Yi-Pin.Lin@health.ny.gov.

John M LeongDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, 136 Harrison Ave., Boston, MA, 02111, USA.

Tufts University · USWadsworth Center · US

Funding

Functional Analyses of Borrelia burgdorferi AdhesinsR01AI118799 · NIAID · MEDICAL COLLEGE OF WISCONSIN · PI CHACONAS, GEORGE, COBURN, JENIFER L · 2016 to 2020

$3.3M

NIAID NIH HHS R01 AI118799

6 · The paper itself

Abstract

Lyme disease Borreliae produces outer surface adhesins to confer bacterial attachment to the extracellular matrix (ECM) components on the surface of mammalian cells. Here, we describe protocols to characterize the activity and specificity of these adhesins by flow cytometry or measurement of the binding of radiolabeled spirochetes to immobilized ECM or mammalian cells.

Indexed as

Bacterial AdhesionAdhesins, BacterialAnimalsBorrelia burgdorferiCell LineExtracellular MatrixFlow CytometryHost-Pathogen InteractionsHumansLyme DiseaseProtein BindingRadioligand AssayAdhesins, BacterialAdhesinsBorrelia burgdorferiExtracellular matrixFlow cytometryLyme diseaseMammalian cellsRadiolabeling

Identifiers

PMID29032536

DOI10.1007/978-1-4939-7383-5_5

PMCPMC6291642

OpenAlexW2763737562

What OpenQuestion holds

Textmetadata

LicenceTDM

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.