ArticleJournal of pharmacokinetics and pharmacodynamics2017
Evaluation and calibration of high-throughput predictions of chemical distribution to tissues.
Article in Journal of pharmacokinetics and pharmacodynamics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 48 citations in OpenAlex.
- Prediction variability in physiologically based pharmacokinetic modeling of tissue disposition under deep uncertainty.NPJ systems biology and applications · 2026Article
- Comparison of physiologically based pharmacokinetic modeling platforms for developmental neurotoxicity in vitro to in vivo extrapolation.Toxicological sciences : an official journal of the Society of Toxicology · 2026Article
- Informatics for toxicokinetics.Journal of pharmacokinetics and pharmacodynamics · 2025Article
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- Machine learning and artificial intelligence in physiologically based pharmacokinetic modeling.Toxicological sciences : an official journal of the Society of Toxicology · 2023Article
- A geospatial modeling approach to quantifying the risk of exposure to environmental chemical mixtures via a common molecular target.The Science of the total environment · 2023Article
- Towards best use and regulatory acceptance of generic physiologically based kinetic (PBK) models for in vitro-to-in vivo extrapolation (IVIVE) in chemical risk assessment.Archives of toxicology · 2022Article
- Evaluation of a rapid, generic human gestational dose model.Reproductive toxicology (Elmsford, N.Y.) · 2022Article
- Advances in computational methods along the exposure to toxicological response paradigm.Toxicology and applied pharmacology · 2022Article
- Prediction of Carboxylesterase 1-mediated In Vivo Drug Interaction between Methylphenidate and Cannabinoids using Static and Physiologically Based Pharmacokinetic Models.Drug metabolism and disposition: the biological fate of chemicals · 2022Article
- IVIVE: Facilitating the Use ofToxics · 2022Review
- Prioritization of chemicals in food for risk assessment by integrating exposure estimates and new approach methodologies: A next generation risk assessment case study.Frontiers in toxicology · 2022Article
- High-throughput PBTK models forExpert opinion on drug metabolism & toxicology · 2021Review
- Development and evaluation of a high throughput inhalation model for organic chemicals.Journal of exposure science & environmental epidemiology · 2020Article
- Bioactivity screening of environmental chemicals using imaging-based high-throughput phenotypic profiling.Toxicology and applied pharmacology · 2020Article
- Assessing Toxicokinetic Uncertainty and Variability in Risk Prioritization.Toxicological sciences : an official journal of the Society of Toxicology · 2019Article
- The Next Generation Blueprint of Computational Toxicology at the U.S. Environmental Protection Agency.Toxicological sciences : an official journal of the Society of Toxicology · 2019Article
- Using the concordance of in vitro and in vivo data to evaluate extrapolation assumptions.PloS one · 2019Article
- Rapid experimental measurements of physicochemical properties to inform models and testing.The Science of the total environment · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Toxicokinetics (TK) provides critical information for integrating chemical toxicity and exposure assessments in order to determine potential chemical risk (i.e., the margin between toxic doses and plausible exposures). For thousands of chemicals that are present in our environment, in vivo TK data are lacking. The publicly available R package "httk" (version 1.8, named for "high throughput TK") draws from a database of in vitro data and physico-chemical properties in order to run physiologically-based TK (PBTK) models for 553 compounds. The PBTK model parameters include tissue:plasma partition coefficients (K
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.