ArticleIrish journal of medical science2018
Clinical evaluation for sublingual immunotherapy with Dermatophagoides farinae drops in adult patients with allergic asthma.
Article in Irish journal of medical science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- Brazilian guidelines for allergen immunotherapy in the treatment of allergic asthma.Revista da Associacao Medica Brasileira (1992) · 2024Article
- Morning Versus Evening Dosing of Sublingual Immunotherapy in Allergic Asthma: A Prospective Study.Frontiers in pediatrics · 2022Article
- Clinical Evaluation for Sublingual Immunotherapy WithFrontiers in medicine · 2021Article
- Sublingual Versus Subcutaneous Immunotherapy for Allergic Rhinitis: What Are the Important Therapeutic and Real-World Considerations?Current allergy and asthma reports · 2020Review
- Effects of Sublingual Duster Mite Drops on Lung Function and Exhaled Nitric Oxide in Children with Multiple and Single Allergic Respiratory Diseases.Canadian respiratory journal · 2020Article
- Chinese guideline on sublingual immunotherapy for allergic rhinitis and asthma.Journal of thoracic disease · 2019Review
- Principles of Allergen Immunotherapy and Its Clinical Application in China: Contrasts and Comparisons with the USA.Clinical reviews in allergy & immunology · 2019Review
- Morphofunctional analysis of antigen uptake mechanisms following sublingual immunotherapy with beads in mice.PloS one · 2018Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
purposeThe efficacy and safety of sublingual immunotherapy (SLIT) in house dust mite-induced allergic asthma (AA) have yet to be firmly established, especially in adult patients. Our objective is to evaluate the efficacy of SLIT with Dermatophagoides farinae drops in adult patients with AA.
methodsOne hundred and thirty-four adult patient data with house dust mite (HDM)-induced AA who had been treated for 2 years were collected. These patient data that we collected were divided into the SLIT group (n = 85) and control group (n = 49). All patients were treated with low to moderate dose of inhaled glucocorticoid and long-acting β2 agonists. Patients in the SLIT group were further treated with D. farinae drops. Clinical scores including the total asthma symptom score (TASS), total asthma medicine score (TAMS), asthma control test (ACT), and peak flow percentage (PEF%) were assessed before treatment and at yearly visits. The presence of adverse events (AEs) were recorded once a month.
resultsBefore treatment, the PEF% in the SLIT group was significantly lower than that in the control group (p < 0.05). After 2 years, both treatments were effective in the clinical scores when compared with baseline values (all p < 0.001). Meanwhile, the SLIT group showed significantly lower TASS and TAMS (all p < 0.001) and higher ACT (p < 0.001) and PEF% (p < 0.05) when compared with the control group. No severe systemic AEs were reported.
conclusionsSLIT with D. farinae drops plus pharmacotherapy is more effective than routine drug treatment in adult patients with AA.
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