Evidence map›Paper›PMID 29032392›Full record

ArticleEuropean journal of applied physiology2017

Exercise and gastrointestinal symptoms: running-induced changes in intestinal permeability and markers of gastrointestinal function in asymptomatic and symptomatic runners.

Elisa Karhu, Richard A Forsgård, Lauri Alanko, Henrik Alfthan, Pirkko Pussinen, Esa Hämäläinen, Riitta Korpela

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of applied physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 5 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 5 syntheses or guidelines pooled it, 92 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Effect of Intensity and Duration of Exercise on Gut Microbiota in Humans: A Systematic Review.International journal of environmental research and public health · 2022
    Pooled it
  4. Pooled it
  5. Pooled it
  6. Trial
  7. Trial
  8. Trial
  9. Trial
  10. Trial
  11. Trial
  12. Trial
  13. Trial
  14. Trial
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Elisa KarhuPharmacology, University of Helsinki, P.O. Box 63, 00014, Helsinki, Finland.
Richard A ForsgårdPharmacology, University of Helsinki, P.O. Box 63, 00014, Helsinki, Finland. richard.forsgard@helsinki.fi.ORCID http://orcid.org/0000-0002-1905-918X
Lauri AlankoClinic for Sports and Exercise Medicine, Foundation for Sport and Exercise Medicine, Helsinki, Finland.
Henrik AlfthanHUSLAB, Helsinki University Hospital, Helsinki, Finland.
Pirkko PussinenOral and Maxillofacial Diseases, University of Helsinki and University Hospital of Helsinki, Helsinki, Finland.
Esa HämäläinenHUSLAB, Helsinki University Hospital, Helsinki, Finland.
Riitta KorpelaPharmacology, University of Helsinki, P.O. Box 63, 00014, Helsinki, Finland.
University of Helsinki · FILIKES – Foundation for Sport and Health Sciences · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAthletes frequently experience gastrointestinal (GI) symptoms during training and competition. Although the prevalence of exercise-induced GI symptoms is high, the mechanisms leading to GI distress during exercise are not fully understood. The aim of this study was to identify running-induced changes in intestinal permeability and markers of GI function and investigate their association with gastrointestinal symptoms.

methodsWe recruited 17 active runners who we allocated as either asymptomatic or symptomatic based on their history of experiencing GI symptoms during running. The participants took part in a running test where they were asked to run for 90 min at 80% of their best 10 km race speed. Intestinal permeability was measured at baseline and after the running test. Levels of serum intestinal fatty acid-binding protein (I-FABP), zonulin, bacterial lipopolysaccharide (LPS), and fecal calprotectin were also measured at baseline and after the running test.

resultsRunning induced a significant increase in intestinal permeability and serum I-FABP concentration but there were no differences between asymptomatic and symptomatic runners. Serum LPS activity did not change from baseline following the running test but the symptomatic group exhibited higher LPS activity at baseline compared to the asymptomatic runners.

conclusionsRunning for 90 min at a challenging pace causes small intestinal damage and increases intestinal permeability. However, these alterations in GI function do not appear to correlate with the development of GI symptoms during running.

Indexed as

Intestinal AbsorptionRunningAdultBiomarkersCholera ToxinFatty Acid-Binding ProteinsFemaleHaptoglobinsHumansIntestinesLeukocyte L1 Antigen ComplexLipopolysaccharidesMalePhysical Conditioning, HumanProtein PrecursorsBiomarkersCholera ToxinFatty Acid-Binding ProteinsHaptoglobinsLeukocyte L1 Antigen ComplexLipopolysaccharidesProtein PrecursorszonulinExerciseGastrointestinal symptomsI-FABPIntestinal permeabilityLPS

Identifiers

PMID29032392
PMCPMC5694518
OpenAlexW2763011046

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.