Evidence map›Paper›PMID 29032382›Full record

ArticleMedical science monitor : international medical journal of experimental and clinical research2017

Angiotensin-Converting Enzyme Gene Deletion Polymorphism is Associated with Lymph Node Metastasis in Colorectal Cancer Patients in a Chinese Population.

Xiao Zheng, Guoli Liu, Gang Cui, Ming Cheng, Nan Zhang, Sanyuan Hu

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medical science monitor : international medical journal of experimental and clinical research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Renin-angiotensin system gene polymorphisms and colorectal cancer risk: a meta-analysis.Journal of the renin-angiotensin-aldosterone system : JRAAS
    Pooled it
  3. Article
  4. Review
  5. Angiotensin-converting enzyme insertion/deletion gene polymorphism in patients with laryngeal cancer.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2023
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Aloe-Emodin Induces Endoplasmic Reticulum Stress-Dependent Apoptosis in Colorectal Cancer Cells.Medical science monitor : international medical journal of experimental and clinical research · 2018
    Article
  11. Relationship of SNP rs35767 in IGF-1 promoter region with susceptibility to colorectal cancer.International journal of clinical and experimental pathology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Xiao ZhengDepartment of General Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, China (mainland).
Guoli LiuFirst Department of Geriatrics, Taian City Central Hospital, Taian, Shandong, China (mainland).
Gang CuiDepartment of General Surgery, Taian City Central Hospital, Taian, Shandong, China (mainland).
Ming ChengDepartment of General Surgery, Taian City Central Hospital, Taian, Shandong, China (mainland).
Nan ZhangDepartment of General Surgery, Taian City Central Hospital, Taian, Shandong, China (mainland).
Sanyuan HuDepartment of General Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, China (mainland).
Taian City Central Hospital · CNQilu Hospital of Shandong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND The purpose of this study was to assess the effect of angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism on the risk of lymph node metastasis (LNM) in colorectal cancer (CRC) patients. MATERIAL AND METHODS We enrolled 146 CRC patients and 106 healthy controls in this study. ACE gene I/D polymorphism was genotyped by polymerase chain reaction (PCR). Hardy-Weinberg equilibrium (HWE) was used to assess the goodness of fit of the genotypes. χ² test was used to calculate the differences of genotype and allele distributions. Odds ratios (ORs) with corresponding 95% confidence intervals (95% CIs) were used to analyze the association between ACE I/D polymorphism and LNM in CRC patients. RESULTS Insertion/deletion (ID) and deletion/deletion (DD) genotypes were frequently observed in CRC patients, but only DD genotype and D allele were related to the susceptibility of CRC (P=0.038, OR=2.158, 95%CI=1.039-4.480; P=0.026, OR=1.501, 95%CI=1.048-2.150). DD genotype and D allele also increased the risk of LNM in CRC patients (P=0.028, OR=2.844, 95%CI=1.107-7.038; P=0.026, OR=1.692, 95%CI=1.063-2.693). CONCLUSIONS DD genotype and D allele of ACE gene I/D polymorphism might increase the risk of LNM in CRC patients.

Indexed as

AdultAgedAllelesAsian PeopleCase-Control StudiesColonic NeoplasmsColorectal NeoplasmsFemaleGene DeletionGene FrequencyGenetic Predisposition to DiseaseGenotypeHumansLymphatic MetastasisLymph NodesMaleACE protein, humanPeptidyl-Dipeptidase A

Identifiers

PMID29032382
PMCPMC5655539
OpenAlexW2762016806

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.