Evidence map›Paper›PMID 29032346›Full record

ArticleVirology2018

Fusion of Anthopleurin-B to AAV2 increases specificity of cardiac gene transfer.

J Emanuel Finet, Xiaoping Wan, J Kevin Donahue

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Gene therapy for atrial fibrillation.Journal of molecular and cellular cardiology · 2024
    Review
  2. AAV vectors: The Rubik's cube of human gene therapy.Molecular therapy : the journal of the American Society of Gene Therapy · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

J Emanuel FinetKrannert Institute of Cardiology, Department of Medicine, Indiana University, Indianapolis, IN, USA.
Xiaoping WanHeart and Vascular Research Center, Case Western Reserve University, MetroHealth Campus, Cleveland, OH, USA.
J Kevin DonahueDivision of Cardiology, Department of Medicine, University of Massachusetts Medical School, 368 Plantation Street, Albert Sherman Center, 7th floor, Worcester, MA 01605, USA. Electronic address: donahuelab@gmail.com.

Funding

Focal Modification of Electrical Conduction in the HeartR01HL067148 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI DONAHUE, J KEVIN · 2002 to 2011
$3.7M
Final preclinical development of AAV gene therapy for atrial fibrillationR01HL130376 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI DONAHUE, J KEVIN · 2016 to 2019
$2.9M
Integrative analysis of electrophysiology in the healed myocardial infarction scarR01HL134185 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI DONAHUE, J KEVIN · 2017 to 2020
$2.8M
GENE TRANSFER APPROACHES TO ATRIAL FIBRILATIONR01HL093486 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI DONAHUE, J KEVIN · 2008 to 2012
$2.0M
Improved Methods for Myocardial Gene TransferR01EB002846 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI DONAHUE, J KEVIN · 2003 to 2005
$883k
Preclinical gene therapy development for post-operative atrial fibrillationR21AG042701 · NIA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI DONAHUE, J KEVIN · 2013 to 2014
$442k
NHLBI NIH HHS R01 HL067148NHLBI NIH HHS R01 HL093486NHLBI NIH HHS R01 HL130376NHLBI NIH HHS R01 HL134185NIA NIH HHS R21 AG042701NIBIB NIH HHS R01 EB002846
6 · The paper itself

Abstract

AAV-mediated gene therapy has become a promising therapeutic strategy for chronic diseases. Its clinical utilization, however, is limited by the potential risk of off-target effects. In this work we attempt to overcome this challenge, hypothesizing that cardiac ion channel-specific ligands could be fused onto the AAV capsid, and narrow its tropism to cardiac myocytes. We successfully fused the cardiac sodium channel (Na

Indexed as

Genetic VectorsGene Transfer, HorizontalTransduction, GeneticViral TropismCapsid ProteinsCell LineDependovirusGenetic TherapyHumansIntercellular Signaling Peptides and ProteinsMyocytes, CardiacNAV1.5 Voltage-Gated Sodium ChannelParvovirinaePeptidesRecombinant Fusion ProteinsVirus Attachmentanthopleurin BCapsid ProteinsIntercellular Signaling Peptides and ProteinsNAV1.5 Voltage-Gated Sodium ChannelPeptidesRecombinant Fusion ProteinsSCN5A protein, humanAAVAnthopleurin-BAttachmentCardiomyocyteNa(v)1.5RetargetingSpecificity

Identifiers

PMID29032346
PMCPMC5705465

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.