ArticleImmunity2017
Differentiation and Protective Capacity of Virus-Specific CD8
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Article in Immunity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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49citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
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Who cites it
49 citing papers in PubMed, 61 citations in OpenAlex.
- IgA is necessary and sufficient to prevent norovirus infection in mice.Science translational medicine · 2026Article
- Type I and III interferons synergize with TNF to promote virally-triggered damage to the intestinal epithelium.bioRxiv : the preprint server for biology · 2026Article
- Mechanisms of Norovirus Immunity: Implications for Vaccine Design.Annual review of pathology · 2026Review
- Current Perspectives and Future Directions in the Immunogenicity Landscape of Norovirus Vaccines.Journal of microbiology and biotechnology · 2025Review
- Environmental stress drives clearance of a persistent enteric virus in mice.Nature microbiology · 2025Article
- Targeting the SARS-CoV-2 reservoir in long COVID.The Lancet. Infectious diseases · 2025Review
- Norovirus co-opts NINJ1 for selective protein secretion.Science advances · 2025Article
- Characteristics of Norovirus capsid protein-specific CD8Virulence · 2024Article
- Sequential early-life viral infections modulate the microbiota and adaptive immune responses to systemic and mucosal vaccination.PLoS pathogens · 2024Article
- Mucosal T-cell responses to chronic viral infections: Implications for vaccine design.Cellular & molecular immunology · 2024Review
- Review
- Interferons and tuft cell numbers are bottlenecks for persistent murine norovirus infection.PLoS pathogens · 2024Article
- Intestinal tuft cell immune privilege enables norovirus persistence.Science immunology · 2024Article
- Intestinal Tuft Cells: Morphology, Function, and Implications for Human Health.Annual review of physiology · 2024Review
- Biogeographical Impacts of Dental, Oral, and Craniofacial Microbial Reservoirs.Journal of dental research · 2023Review
- Tuft-cell-intrinsic and -extrinsic mediators of norovirus tropism regulate viral immunity.Cell reports · 2022Article
- The multifunctional nature of CD103 (αEβ7 integrin) signaling in tissue-resident lymphocytes.American journal of physiology. Cell physiology · 2022Review
- Article
- Immunity to enteric viruses.Immunity · 2022Review
- Restriction of Viral Replication, Rather than T Cell Immunopathology, Drives Lethality in Murine Norovirus CR6-Infected STAT1-Deficient Mice.Journal of virology · 2022Article
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 1 country.
Vesselin T TomovDepartment of Medicine, Division of Gastroenterology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA. Electronic address: tomovv@pennmedicine.upenn.edu.
Olesya PalkoDepartment of Medicine, Division of Gastroenterology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
Chi Wai LauDepartment of Medicine, Division of Gastroenterology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
Ajinkya PattekarDepartment of Medicine, Division of Gastroenterology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
Yuhang SunDepartment of Medicine, Division of Gastroenterology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
Ralitza TachevaDepartment of Medicine, Division of Gastroenterology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
Bertram BengschDepartment of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
Sasikanth ManneDepartment of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
Gabriela L CosmaDepartment of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Laurence C EisenlohrDepartment of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia Research Institute and University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
Timothy J NiceDepartment of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR 97239, USA.
Herbert W VirginDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
E John WherryDepartment of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA. Electronic address: wherry@pennmedicine.upenn.edu.
University of Pennsylvania · USChildren's Hospital of Philadelphia · USOregon Health & Science University · USThomas Jefferson University · USWashington University in St. Louis · US
Funding
UNIVERSITY OF PENNSYLVANIA CAN CTR SUPPORT GRANTP30CA016520 · NCI · UNIVERSITY OF PENNSYLVANIA · PI SHELLEY L BERGER · 1985 to 2026
$222.3MVirology CoreU19AI082630 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI GEORG Michael LAUER · 2009 to 2026
$48.1MGenetic and Pathway Analysis CoreU19AI109725 · NIAID · WASHINGTON UNIVERSITY · PI ALLEN, PAUL M · 2014 to 2018
$32.7MTRANSGENIC AND CHIMERIC MOUSE COREP30DK050306 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI Ken Hashigiwa Cadwell · 1997 to 2026
$32.5MUNIVERSITY OF PENNSYLVANIA TRAINING IN GASTROENTEROLOGYT32DK007066 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI JONATHAN P KATZ · 1986 to 2026
$11.7MRegulation of protective immunity following enteric viral infectionU01AI095608 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI ARTIS, DAVID, SONNENBERG, GREGORY F · 2011 to 2025
$11.0MP3: Chemokine-Mediated T Cell Trafficking in HIV Transmission and Immune ResponseP01AI112521 · NIAID · HARVARD MEDICAL SCHOOL · PI VON ANDRIAN, ULRICH H · 2014 to 2018
$9.8MRegulation of T cell differentiation during enteric viral infectionK08DK097301 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI TOMOV, VESSELIN · 2012 to 2016
$776kCellular targets of acute and chronic strains of MNVR03DK110397 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI TOMOV, VESSELIN · 2017 to 2018
$161kNCI NIH HHS P30 CA016520NIAID NIH HHS L30 AI096377NIAID NIH HHS P01 AI112521NIAID NIH HHS U01 AI095608NIAID NIH HHS U19 AI082630NIAID NIH HHS U19 AI109725NIDDK NIH HHS K08 DK097301NIDDK NIH HHS P30 DK050306NIDDK NIH HHS R03 DK110397NIDDK NIH HHS T32 DK007066
Abstract
Noroviruses can establish chronic infections with active viral shedding in healthy humans but whether persistence is associated with adaptive immune dysfunction is unknown. We used genetically engineered strains of mouse norovirus (MNV) to investigate CD8
Indexed as
AnimalsCaliciviridae InfectionsCD8-Positive T-LymphocytesCell DifferentiationCell LineCellular MicroenvironmentGastroenteritisGene Expression ProfilingGene OntologyHEK293 CellsHost-Pathogen InteractionsHumansImmunologic MemoryMice, Inbred C57BLNorovirusOligonucleotide Array Sequence Analysisenteric viral persistencenorovirusT cell exhaustionT cell inflationtissue-resident memory T cells
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.