ArticleMolecular metabolism2017
Reduced renal sympathetic nerve activity contributes to elevated glycosuria and improved glucose tolerance in hypothalamus-specific Pomc knockout mice.
Article in Molecular metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 42 citations in OpenAlex.
- Increase in endogenous glucose production with SGLT2 inhibition is attenuated in individuals who underwent kidney transplantation and bilateral native nephrectomy.Diabetologia · 2020Trial
- Renal glycosuria triggers a coordinated mannose and glutamine metabolic program to maintain glucose homeostasis.Cell reports · 2026Article
- Hypothalamic POMC neurons regulate intestinal glucose absorption via a gut-brain circuit.Nature communications · 2026Article
- Metabolic Reprogramming Coordinates Mannose and Glutamine Metabolism to Maintain Glucose Homeostasis During Glycosuria.bioRxiv : the preprint server for biology · 2026Article
- Contribution of metabolism-independent glucose sensing to metabolic homeostasis.Trends in endocrinology and metabolism: TEM · 2026Review
- A kidney-hypothalamus axis promotes compensatory glucose production in response to glycosuria.eLife · 2024Article
- Neural Circuits Underlying Reciprocal Cardiometabolic Crosstalk: 2023 Arthur C. Corcoran Memorial Lecture.Hypertension (Dallas, Tex. : 1979) · 2024Article
- Unravelling the effect of renal denervation on glucose homeostasis: more questions than answers?Acta diabetologica · 2024Review
- The hypothalamus as a key regulator of glucose homeostasis: emerging roles of the brain renin-angiotensin system.American journal of physiology. Cell physiology · 2023Review
- Transcription factor c-Maf deletion improves streptozotocin-induced diabetic nephropathy by directly regulating Sglt2 and Glut2.JCI insight · 2023Article
- SK3 in POMC neurons plays a sexually dimorphic role in energy and glucose homeostasis.Cell & bioscience · 2022Article
- Renoprotective Effects of SGLT2 Inhibitors.Heart failure clinics · 2022Review
- Loss of function of renal Glut2 reverses hyperglycaemia and normalises body weight in mouse models of diabetes and obesity.Diabetologia · 2022Article
- Antiarrhythmic effects and mechanisms of sodium-glucose cotransporter 2 inhibitors: A mini review.Frontiers in cardiovascular medicine · 2022Review
- Gabra5 plays a sexually dimorphic role in POMC neuron activity and glucose balance.Frontiers in endocrinology · 2022Article
- High urinary glucose is associated with improved renal prognosis in patients with diabetes mellitus.Journal of diabetes investigation · 2021Observational
- Central nervous system regulation of organismal energy and glucose homeostasis.Nature metabolism · 2021Review
- Hypothalamic MC4R regulates glucose homeostasis through adrenaline-mediated control of glucose reabsorption via renal GLUT2 in mice.Diabetologia · 2021Article
- Optogenetic stimulation of the liver-projecting melanocortinergic pathway promotes hepatic glucose production.Nature communications · 2020Article
- Hypothalamic POMC deficiency increases circulating adiponectin despite obesity.Molecular metabolism · 2020Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveHypothalamic arcuate nucleus-specific pro-opiomelanocortin deficient (ArcPomc
methodsWe measured RSNA by multifiber recording directly from the nerves innervating the kidneys in ArcPomc
resultsConsistent with our hypothesis, we found that basal RSNA was decreased in ArcPomc
conclusionHence, we conclude that ArcPomc is essential in maintaining basal RSNA and that elevated glycosuria is a possible mechanism to explain improved glucose tolerance after renal denervation in drug resistant hypertensive patients.
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Registered trials
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