Evidence map›Paper›PMID 29031710›Full record

ReviewMolecular metabolism2017

Na

Swalpa Udit, Michael Burton, Joseph M Rutkowski, Syann Lee, Angie L Bookout, Philipp E Scherer, Joel K Elmquist, Laurent Gautron

Open access · goldAbstract readReview
In one paragraph

Review in Molecular metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Molecular Effects of Physical Activity and Body Composition: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2025
    Pooled it
  2. Article
  3. Article
  4. Autonomic control of energy balance and glucose homeostasis.Experimental & molecular medicine · 2022
    Review
  5. Article
  6. Dorsal Root Ganglia Macrophages Maintain Osteoarthritis Pain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Swalpa UditDivision of Hypothalamic Research, Department of Internal Medicine, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas 75390, TX, USA.
Michael BurtonDivision of Hypothalamic Research, Department of Internal Medicine, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas 75390, TX, USA.
Joseph M RutkowskiTouchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas 75390, TX, USA.
Syann LeeDivision of Hypothalamic Research, Department of Internal Medicine, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas 75390, TX, USA.
Angie L BookoutDivision of Hypothalamic Research, Department of Internal Medicine, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas 75390, TX, USA; Department of Pharmacology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas 75390, TX, USA.
Philipp E SchererTouchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas 75390, TX, USA.
Joel K ElmquistDivision of Hypothalamic Research, Department of Internal Medicine, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas 75390, TX, USA. Electronic address: Joel.Elmquist@utsouthwestern.edu.
Laurent GautronDivision of Hypothalamic Research, Department of Internal Medicine, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas 75390, TX, USA. Electronic address: Laurent.Gautron@UTSouthwestern.edu.
The University of Texas Southwestern Medical Center · US

Funding

Novel Mechanisms Regulating the Adipocyte-Brain-Hepatocyte AxisP01DK088761 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI SCHERER, PHILIPP E · 2010 to 2019
$17.4M
Adiponectin, A Protein Secreted From Adipose TissueR01DK055758 · NIDDK · YESHIVA UNIVERSITY · PI SCHERER, PHILIPP E · 2000 to 2024
$10.9M
Central Mechanisms Regulating Energy Homeostasis, Project 2 of 10RL1DK081185 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI ELMQUIST, JOEL K. · 2007 to 2011
$3.8M
Mouse Phenotype Core, Project 9 of 10PL1DK081182 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI RUSSELL, DAVID W. · 2007 to 2011
$2.0M
The Role of Cell-specific TLR-4 Signaling in Developing Chronic PainK22NS096030 · NINDS · UNIVERSITY OF TEXAS DALLAS · PI BURTON, MICHAEL D · 2016 to 2019
$838k
Taskforce for Obesity Research at Southwestern (TORS)UL1RR024923 · NCRR · UT SOUTHWESTERN MEDICAL CENTER · PI HORTON, JAY D · 2007 to 2007
$235k
NCRR NIH HHS UL1 RR024923NIDDK NIH HHS P01 DK088761NIDDK NIH HHS PL1 DK081182NIDDK NIH HHS R01 DK055758NIDDK NIH HHS RL1 DK081185NINDS NIH HHS K22 NS096030
6 · The paper itself

Abstract

OBJECTIVE AND

methodsMetabolic viscera and their vasculature are richly innervated by peripheral sensory neurons. Here, we examined the metabolic and inflammatory profiles of mice with selective ablation of all Na

resultsWhile mice lacking sensory neurons displayed no differences in body weight, food intake, energy expenditure, or body composition compared to controls on chow diet, ablated mice developed an exaggerated inflammatory response to high-fat feeding characterized by bouts of weight loss, splenomegaly, elevated circulating interleukin-6 and hepatic serum amyloid A expression. This phenotype appeared to be directly mediated by the ingestion of saturated lipids.

conclusionsThese data demonstrate that the Na

Indexed as

Acute-Phase ReactionAnimalsBody CompositionBody WeightDietary FatsDiet, High-FatEatingEnergy MetabolismHomeostasisMiceNAV1.8 Voltage-Gated Sodium ChannelNeurons, AfferentObesitySensory Receptor CellsVisceraWeight LossDietary FatsNAV1.8 Voltage-Gated Sodium ChannelScn10a protein, mouseDeafferentationDiphtheria toxinEnergy homeostasisInflammationNodose ganglionObesity

Identifiers

PMID29031710
PMCPMC5641637
OpenAlexW2742628793

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.