ArticleThe Journal of infection2018
Rotavirus vaccination takes seasonal signature of childhood diarrhea back to pre-sanitation era in Brazil.
Article in The Journal of infection, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
6 citing papers in PubMed.
- Unguided self-help to bridge waiting time for face-to-face therapy in a university student mental health service: interrupted time series analysis.BJPsych open · 2025Article
- Spatio-temporal impact of self-financed rotavirus vaccination on rotavirus and acute gastroenteritis hospitalisations in the Valencia region, Spain.BMC infectious diseases · 2020Article
- Prevalence ofThe Pan African medical journal · 2020Article
- Seasonality of Rotavirus Hospitalizations at Costa Rica's National Children's Hospital in 2010-2015.International journal of environmental research and public health · 2019Article
- Etiology and severity of diarrheal diseases in infants at the semiarid region of Brazil: A case-control study.PLoS neglected tropical diseases · 2019Article
- Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
objectivesThis study aimed to examine the previously unknown long-term spatio-temporal patterns in diarrheal morbidity and mortality across age groups and geography in Brazil under the light of evolving socioeconomic factors and interventions.
methodsNationwide mortality (1979-2014) and hospitalization (1998-2014) data were obtained from the Brazilian Ministry of Health. Analyses of long-term secular trends and seasonality of diarrheal morbidity and mortality were performed in EPIPOI (www.epipoi.info).
resultsFor most states, the primary peak in mortality risk among children under 5 years occurred from December-April (summer/early autumn) from 1979-1988. From 2000-2005 (before the 2006 implementation of rotavirus vaccination), the pattern switched to June-October (winter/early spring). By 2007-2014, the peak in mortality shifted back towards summer/early autumn. A similar pattern was observed for hospitalizations. These patterns were particularly apparent in non-equatorial regions of the country. In contrast, the risk of diarrhea-related death among older children (5-19 years) did not demonstrate well-defined seasonality or spatial patterns.
conclusionsRotavirus vaccination policies were associated with a shift in the timing of seasonal peaks in children under 5, reminiscent of the summer diarrhea period common decades prior. Additionally, young children were shown to have distinct disease patterns compared to other age groups, suggesting different etiologies.
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