Evidence map›Paper›PMID 29031520›Full record

ArticleGeriatric nursing (New York, N.Y.)

Executive function: Responses to aerobic exercise in Alzheimer's disease.

Fang Yu, David M Vock, Terry R Barclay

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Geriatric nursing (New York, N.Y.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 4 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 4 syntheses or guidelines pooled it, 32 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Review
  6. Article
  7. Article
  8. Article
  9. The Importance of Exercise in Alzheimer's Disease and the Minds in MotionJournal of functional morphology and kinesiology · 2020
    Article
  10. Article
  11. Observational
  12. Gender Differences in the Association Between Hearing Loss and Cognitive Function.American journal of Alzheimer's disease and other dementias
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Fang YuUniversity of Minnesota School of Nursing, Minneapolis, MN, USA. Electronic address: yuxxx244@umn.edu.
David M VockUniversity of Minnesota School of Public Health Division of Biostatistics, Minneapolis, MN, USA. Electronic address: vock@umn.edu.
Terry R BarclayUniversity of Minnesota Department of Neurology, Minneapolis, MN, USA. Electronic address: tbarclay@umn.edu.
University of Minnesota · US

Funding

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR000114 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R · 2012 to 2015
$35.0M
Scholar Development Clinical Research (RMI)K12RR023247 · NCRR · UNIVERSITY OF MINNESOTA TWIN CITIES · PI LUEPKER, RUSSELL V · 2005 to 2009
$13.5M
Aerobic Exercise in Alzheimer's Disease: Cognition and Hippocampal Volume EffectsR01AG043392 · NIA · UNIVERSITY OF MINNESOTA · PI YU, FANG · 2013 to 2018
$3.2M
NCRR NIH HHS K12 RR023247NIA NIH HHS R01 AG043392
6 · The paper itself

Abstract

Executive dysfunction occurs early and is prevalent in Alzheimer's disease (AD). This study tested the ability of different measures for identifying changes in executive function and the effect of 6-months of aerobic exercise on executive function in older adults with mild to moderate AD, using a single-group, repeated-measures design (n = 28, age 78.1 ± 8.37). Factor analysis and linear mixed-effects model analyses showed that individually the Exit Interview-25 (EXIT-25), Behavioral Dyscontrol Scale (BDS), and Golden Stroop test were the preferred instruments for measuring changes in executive function in the sample. The COWAT and TMT had substantial floor effects limiting their ability to identify changes in executive function. A single latent factor was sufficient to describe the heterogeneity of executive function. Over 6 months, aerobic exercise maintained executive function (effect size = -0.11, -0.24, -0.27, and -0.21 for the EXIT-25, BDS, Stroop, and latent factor, respectively). Decline in the latent factor (effect size = -0.21, p = 0.06) was minimal and comparable to that in global cognition (effect size = -0.20, p = 0.34). Aerobic exercise may be effective on maintaining executive function in AD.

Indexed as

Executive FunctionAgedAlzheimer DiseaseCognitionExerciseFemaleHumansMaleNeuropsychological TestsAgingAlzheimer's diseaseCognitionExecutive functionExercise

Identifiers

PMID29031520
PMCPMC5897173
OpenAlexW2764310601

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.