Evidence map›Paper›PMID 29031230›Full record

ArticleNuclear medicine and biology2018

Astatine-211 labeled anti-HER2 5F7 single domain antibody fragment conjugates: radiolabeling and preliminary evaluation.

Jaeyeon Choi, Ganesan Vaidyanathan, Eftychia Koumarianou, Choong Mo Kang, Michael R Zalutsky

Abstract readEvaluation Study
In one paragraph

Article in Nuclear medicine and biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed.

  1. A Novel CD147-Targeting Nanobody for Immuno-PET Imaging of Liver Cancer.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
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  4. Theranostic Application of Radiohalogens in Nuclear Medicine.Nuclear medicine and molecular imaging · 2025
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  5. Ortho-functionalization of aScientific reports · 2025
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  7. Review
  8. Scalability study on [EJNMMI radiopharmacy and chemistry · 2024
    Article
  9. Review
  10. Article
  11. Review
  12. RSC medicinal chemistry · 2024
    Article
  13. Review
  14. Review
  15. Review
  16. Review
  17. Effective Treatment of Human Breast Carcinoma Xenografts with Single-DoseJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Article
  18. Review
  19. Article
  20. Efficient Production of the PET RadionuclidePharmaceuticals (Basel, Switzerland) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jaeyeon ChoiDepartment of Radiology, Duke University Medical Center, Durham, North Carolina, 27710, USA.
Ganesan VaidyanathanDepartment of Radiology, Duke University Medical Center, Durham, North Carolina, 27710, USA.
Eftychia KoumarianouDepartment of Radiology, Duke University Medical Center, Durham, North Carolina, 27710, USA.
Choong Mo KangDepartment of Radiology, Duke University Medical Center, Durham, North Carolina, 27710, USA.
Michael R ZalutskyDepartment of Radiology, Duke University Medical Center, Durham, North Carolina, 27710, USA. Electronic address: zalut001@mc.duke.edu.

Funding

RADIOTHERAPY USING MONOCLONAL ANTIBODIES AND ASTATINER01CA042324 · NCI · DUKE UNIVERSITY · PI ZALUTSKY, MICHAEL ROD · 1985 to 2020
$4.6M
ASTATINE AND IODINE RADIOLABELED MONOCLONAL ANTIBODIESR37CA042324 · NCI · DUKE UNIVERSITY · PI ZALUTSKY, MICHAEL ROD · 1999 to 2008
$3.8M
NCI NIH HHS R01 CA042324NCI NIH HHS R37 CA042324
6 · The paper itself

Abstract

introductionDerived from heavy chain only camelid antibodies, ~15-kDa single-domain antibody fragments (sdAbs) are an attractive platform for developing molecularly specific imaging probes and targeted radiotherapeutics. The rapid tumor accumulation and normal tissue clearance of sdAbs might be ideal for use with

methods[

resultsRadiochemical yields for Boc

conclusionThese

Indexed as

AnimalsAstatineBreast NeoplasmsErb-b2 Receptor Tyrosine KinasesFemaleHumansMiceMice, SCIDRadiopharmaceuticalsSingle-Domain AntibodiesTissue DistributionTumor Cells, CulturedXenograft Model Antitumor AssaysAstatineAstatine-211Erb-b2 Receptor Tyrosine KinasesRadiopharmaceuticalsSingle-Domain AntibodiesAstatine-211HER2NanobodySingle domain antibody fragmentVHHα-particle

Identifiers

PMID29031230
PMCPMC5732883

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.