Evidence map›Paper›PMID 29031027›Full record

ArticleJournal of veterinary internal medicine2017

Evaluation of Renal Perfusion in Hyperthyroid Cats before and after Radioiodine Treatment.

E Stock, S Daminet, D Paepe, E Buresova, E Vandermeulen, P Smets, L Duchateau, J H Saunders, K Vanderperren

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of veterinary internal medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.1field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

E StockDepartment of Medical Imaging of Domestic Animals, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.ORCID http://orcid.org/0000-0002-9982-1532
S DaminetSmall Animal Department, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
D PaepeSmall Animal Department, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
E BuresovaSmall Animal Department, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
E VandermeulenDepartment of Medical Imaging of Domestic Animals, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
P SmetsSmall Animal Department, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
L DuchateauDepartment of Comparative Physiology and Biometry (Duchateau), Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
J H SaundersDepartment of Medical Imaging of Domestic Animals, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
K VanderperrenDepartment of Medical Imaging of Domestic Animals, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
Ghent University · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHyperthyroidism and chronic kidney disease (CKD) are common in elderly cats. Consequently, both diseases often occur concurrently. Furthermore, renal function is affected by thyroid status. Because changes in renal perfusion play an important role in functional renal changes in hyperthyroid cats, investigation of renal perfusion may provide novel insights.

objectivesTo evaluate renal perfusion in hyperthyroid cats with contrast-enhanced ultrasound (CEUS). ANIMALS: A total of 42 hyperthyroid cats was included and evaluated before and 1 month after radioiodine treatment.

methodsProspective intrasubject clinical trial of contrast-enhanced ultrasound using a commercial contrast agent (SonoVue) to evaluate renal perfusion. Time-intensity curves were created, and perfusion parameters were calculated by off-line software. A linear mixed model was used to examine differences between pre- and post-treatment perfusion parameters.

resultsAn increase in several time-related perfusion parameters was observed after radioiodine treatment, indicating a decreased blood velocity upon resolution of the hyperthyroid state. Furthermore, a small post-treatment decrease in peak enhancement was present in the renal medulla, suggesting a lower medullary blood volume. CONCLUSIONS AND CLINICAL IMPORTANCE: Contrast-enhanced ultrasound indicated a higher cortical and medullary blood velocity and higher medullary blood volume in hyperthyroid cats before radioactive treatment in comparison with 1-month post-treatment control.

Indexed as

AnimalsBlood Flow VelocityCat DiseasesCatsFemaleHyperthyroidismIodine RadioisotopesKidneyMalePerfusion ImagingPhospholipidsRenal CirculationSulfur HexafluorideUltrasonographycontrast agent BR1Iodine RadioisotopesPhospholipidsSulfur HexafluorideContrast-enhanced ultrasoundFelineHyperthyroidismKidney

Identifiers

PMID29031027
PMCPMC5697172
OpenAlexW2761650468

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.