ReviewDevelopmental neurobiology2018
Development and maintenance of the brain's immune toolkit: Microglia and non-parenchymal brain macrophages.
Review in Developmental neurobiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 51 citations in OpenAlex.
- Targeting glial modulation: molecular mechanisms of Polygonatum in neurological disorders.Frontiers in pharmacology · 2026Review
- Type I interferon signalling and interferon-responsive microglia in health and disease.The FEBS journal · 2025Review
- In vivo imaging of the barrier properties of the glia limitans during health and neuroinflammation.Nature communications · 2025Article
- Pu.1/Spi1 dosage controls the turnover and maintenance of microglia in zebrafish and mammals.eLife · 2025Article
- Evolution of Alzheimer's Disease Therapeutics: From Conventional Drugs to Medicinal Plants, Immunotherapy, Microbiotherapy and Nanotherapy.Pharmaceutics · 2025Review
- Effects of Ischemic Stroke on Interstitial Fluid Clearance in Mouse Brain: a Bead Study.Cellular and molecular neurobiology · 2023Article
- Trends in perivascular macrophages research from 1997 to 2021: A bibliometric analysis.CNS neuroscience & therapeutics · 2023Article
- Perivascular macrophages in high-fat diet-induced hypothalamic inflammation.Journal of neuroinflammation · 2022Review
- Pial Vessel-Associated Microglia/Macrophages Increase in Female Dahl-SS/Jr Rats Independent of Pregnancy History.International journal of molecular sciences · 2022Article
- Microglia and Microglia-Like Cells: Similar but Different.Frontiers in cellular neuroscience · 2022Review
- Transcriptional and epigenetic regulation of microglia in maintenance of brain homeostasis and neurodegeneration.Frontiers in molecular neuroscience · 2022Review
- Subventricular zone/white matter microglia reconstitute the empty adult microglial niche in a dynamic wave.eLife · 2021Article
- Current knowledge on the immune microenvironment and emerging immunotherapies in diffuse midline glioma.EBioMedicine · 2021Review
- Macrophage reprogramming for therapy.Immunology · 2021Review
- Progenitor cell therapy for acquired pediatric nervous system injury: Traumatic brain injury and acquired sensorineural hearing loss.Stem cells translational medicine · 2021Review
- Baicalein Ameliorates Epilepsy Symptoms in a Pilocarpine-Induced Rat Model by Regulation of IGF1R.Neurochemical research · 2020Article
- Microglia Actively Remodel Adult Hippocampal Neurogenesis through the Phagocytosis Secretome.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Dwellers and Trespassers: Mononuclear Phagocytes at the Borders of the Central Nervous System.Frontiers in immunology · 2020Review
- A Cautionary Note for COVID-19 Survivors: Potential Long-term Risk for Alzheimer's Disease.American journal of biomedical science & research · 2020Article
- Intermediate progenitors and Tbr2 in cortical development.Journal of anatomy · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microglia and non-parenchymal macrophages located in the perivascular space, the meninges and the choroid plexus are independent immune populations that play vital roles in brain development, homeostasis, and tissue healing. Resident macrophages account for a significant proportion of cells in the brain and their density remains stable throughout the lifespan thanks to constant turnover. Microglia develop from yolk sac progenitors, later evolving through intermediate progenitors in a fine-tuned process in which intrinsic factors and external stimuli combine to progressively sculpt their cell type-specific transcriptional profiles. Recent evidence demonstrates that non-parenchymal macrophages are also generated during early embryonic development. In recent years, the development of powerful fate mapping approaches combined with novel genomic and transcriptomic methodologies have greatly expanded our understanding of how brain macrophages develop and acquire specialized functions, and how cell population dynamics are regulated. Here, we review the transcription factors, epigenetic remodeling, and signaling pathways orchestrating the embryonic development of microglia and non-parenchymal macrophages. Next, we describe the dynamics of the macrophage populations of the brain and discuss the role of progenitor cells, to gain a better understanding of their functions in the healthy and diseased brain. © 2017 Wiley Periodicals, Inc. Develop Neurobiol 78: 561-579, 2018.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.