ArticleClinical neuroradiology2019
Magnetic Resonance Neurography : Normal Values and Demographic Determinants of Nerve Caliber and T2 Relaxometry in 60 healthy individuals.
Article in Clinical neuroradiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Magnetic Resonance Imaging as a Biomarker in Diabetic and HIV-Associated Peripheral Neuropathy: A Systematic Review-Based Narrative.Frontiers in neuroscience · 2021Pooled it
- Body size and intracranial volume interact with the structure of the central nervous system: A multi-center in vivo neuroimaging study.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Automated peripheral nerve segmentation for MR-neurography.European radiology experimental · 2024Article
- Assessment of traumatic mandibular nerve using MR neurography sequence: a preliminary study.BMC oral health · 2024Article
- Multiparametric Quantitative MRI of Peripheral Nerves in the Leg: A Reliability Study.Journal of magnetic resonance imaging : JMRI · 2024Article
- Quantitative MR Neurography in Multifocal Motor Neuropathy and Amyotrophic Lateral Sclerosis.Diagnostics (Basel, Switzerland) · 2023Article
- Dorsal Root Ganglia Volume-Normative Values, Correlation with Demographic Determinants and Reliability of Three Different Methods of Volumetry.Diagnostics (Basel, Switzerland) · 2022Article
- Magnetization Transfer Ratio of Peripheral Nerve and Skeletal Muscle : Correlation with Demographic Variables in Healthy Volunteers.Clinical neuroradiology · 2022Article
- Quantitative MR-Neurography at 3.0T: Inter-Scanner Reproducibility.Frontiers in neuroscience · 2022Article
- Reliability and reproducibility of sciatic nerve magnetization transfer imaging and T2 relaxometry.European radiology · 2021Article
- Advances in imaging technologies for the assessment of peripheral neuropathies in rheumatoid arthritis.Rheumatology international · 2021Review
- MR Neurography: Normative Values in Correlation to Demographic Determinants in Children and Adolescents.Clinical neuroradiology · 2020Article
- T2 mapping of the distal sciatic nerve in healthy subjects and patients suffering from lumbar disc herniation with nerve compression.Magma (New York, N.Y.) · 2020Article
- Effect of Lateral Sliding Calcaneus Osteotomy on Tarsal Tunnel Pressure.Foot & ankle orthopaedics · 2020Article
- Prevalence of fascicular hyperintensities in peripheral nerves of healthy individuals with regard to cerebral white matter lesions.European radiology · 2019Article
- Segmentation of Peripheral Nerves From Magnetic Resonance Neurography: A Fully-Automatic, Deep Learning-Based Approach.Frontiers in neurology · 2018Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo establish normal values and to identify demographic determinants of quantitative biomarkers in magnetic resonance neurography (MRN).
methodsIn this study 60 healthy individuals (5 men and 5 women of every decade between 20 and 80 years) were examined according to a standardized MRN protocol at 3 T, including multiecho T2 relaxometry. Nerve cross-sectional area (CSA), transverse relaxation time (T2), and proton spin density (PSD) were assessed for the sciatic, tibial, median, ulnar, and radial nerves. Correlation with demographic variables, such as height, weight, body mass index (BMI), and age was expressed by Pearson coefficients and t‑tests were used to compare MRN biomarkers between men and women with and without normalization to body weight and BMI by linear regression.
resultsThe average nerve CSA correlated moderately with height (r = 0.28, p = 0.04), weight (r = 0.40, p = 0.002), and BMI (r = 0.35, p = 0.008), but not with age (r = 0.23, p = 0.09). While T2 did not correlate with demographic parameters, PSD was strongly inversely associated with BMI (r = -0.64, p < 0.001) and weight (r = -0.557, p < 0.001). Sex-dependent differences in imaging marker values were found for CSA but became negligible after normalization to body weight.
conclusionQuantitative biomarkers of MRN co-vary with demographic variables. As particularly important determinants, we identified body weight for nerve CSA and BMI for PSD. The presented normal values and demographic determinants may assist investigations into the potential of MRN biomarkers in further disease-specific studies.
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