ArticleNature communications2017
CCDC88B is required for pathogenesis of inflammatory bowel disease.
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Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 29 citations in OpenAlex.
- Gut-reproduction axis: genome-wide pleiotropic and prospective evidence linking inflammatory bowel disease with gynecological disorders.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Article
- A Phenome-Wide Mendelian Randomization and Colocalization Study Reveals Genetic Association Between PBC and Other Autoimmune Disorders.Canadian journal of gastroenterology & hepatology · 2025Article
- Organosilicone double-long-chain diquaternary ammonium salt acts as a biofilm scavenger to ameliorate colitis induced by dextran sulfate sodium salt.Frontiers in immunology · 2025Article
- Fine-mapping and molecular characterisation of primary sclerosing cholangitis genetic risk loci.Nature communications · 2024Article
- Pseudonormal Morphology of Salivary Gland Adenoid Cystic Carcinoma Cells Subverts the Antitumor Reactivity of Immune Cells: A Tumour-Cell-Based Initiation of Immune Evasion.Cancer reports (Hoboken, N.J.) · 2024Article
- CCDC88B interacts with RASAL3 and ARHGEF2 and regulates dendritic cell function in neuroinflammation and colitis.Communications biology · 2024Article
- Pharmacological effects of ginseng and ginsenosides on intestinal inflammation and the immune system.Frontiers in immunology · 2024Review
- Preclinical 3D-model supports an invisibility cloak for adenoid cystic carcinoma.Scientific reports · 2023Article
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- The genetic architecture of blood pressure variability: A genome-wide association study of 9370 participants from UK Biobank.Journal of clinical hypertension (Greenwich, Conn.) · 2022Article
- Loss of NFE2L3 protects against inflammation-induced colorectal cancer through modulation of the tumor microenvironment.Oncogene · 2022Article
- Forward Genetics in Apicomplexa Biology: The Host Side of the Story.Frontiers in cellular and infection microbiology · 2022Review
- Integrative multiomics analysis highlights immune-cell regulatory mechanisms and shared genetic architecture for 14 immune-associated diseases and cancer outcomes.American journal of human genetics · 2021Article
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- WGCNA reveals key gene modules regulated by the combined treatment of colon cancer with PHY906 and CPT11.Bioscience reports · 2020Article
- Current Insights in Genetics of Sarcoidosis: Functional and Clinical Impacts.Journal of clinical medicine · 2020Review
- Inactivation of Interferon Regulatory Factor 1 Causes Susceptibility to Colitis-Associated Colorectal Cancer.Scientific reports · 2019Article
- Ankylosing Spondylitis: A Trade Off of HLA-B27, ERAP, and Pathogen Interconnections? Focus on Sardinia.Frontiers in immunology · 2019Article
- Genetic analysis of cerebral malaria in the mouse model infected with Plasmodium berghei.Mammalian genome : official journal of the International Mammalian Genome Society · 2018Review
- Identification and experimental validation of Alzheimer's disease hub genes via bioinformatics and machine learning.Journal of Alzheimer's disease reportsArticle
Corrections and comments
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Authors and funding
20 authors at 9 institutions in 4 countries.
Nassima FodilMcGill Center for the Study of Complex Traits, Department of Human Genetics, Department of Biochemistry, McGill University, 3649 Sir William Osler Promenade, Montreal, QC, Canada, H3G 0B1. nassima.fodil@mcgill.ca.
Neda MoradinMcGill Center for the Study of Complex Traits, Department of Human Genetics, Department of Biochemistry, McGill University, 3649 Sir William Osler Promenade, Montreal, QC, Canada, H3G 0B1.
Vicki LeungMcGill Center for the Study of Complex Traits, Department of Human Genetics, Department of Biochemistry, McGill University, 3649 Sir William Osler Promenade, Montreal, QC, Canada, H3G 0B1.
Jean-Frederic OlivierMcGill Center for the Study of Complex Traits, Department of Human Genetics, Department of Biochemistry, McGill University, 3649 Sir William Osler Promenade, Montreal, QC, Canada, H3G 0B1.
Irena RadovanovicMcGill Center for the Study of Complex Traits, Department of Human Genetics, Department of Biochemistry, McGill University, 3649 Sir William Osler Promenade, Montreal, QC, Canada, H3G 0B1.ORCID http://orcid.org/0000-0002-3823-3729
Thiviya JeyakumarMcGill Center for the Study of Complex Traits, Department of Human Genetics, Department of Biochemistry, McGill University, 3649 Sir William Osler Promenade, Montreal, QC, Canada, H3G 0B1.
Manuel Flores MolinaCentre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), 900, Saint Denis Street, Pavillion R, Montreal, QC, Canada, H20A9.
Ashley McFarquharMcGill Center for the Study of Complex Traits, Department of Human Genetics, Department of Biochemistry, McGill University, 3649 Sir William Osler Promenade, Montreal, QC, Canada, H3G 0B1.
Romain CayrolDépartement de Pathologie et de Biologie Cellulaire de l'Université de Montréal, C.P. 6128, succ. Centre-ville, Montréal, QC, Canada, H3C 3J7.
Dominique BozecImmunology Institute, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Naglaa H ShoukryCentre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), 900, Saint Denis Street, Pavillion R, Montreal, QC, Canada, H20A9.
Michiaki KuboLaboratory for Genotyping Development, Center for Integrative Medical Sciences, RIKEN 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan.
Julia DimitrievaUnit of Animal Genomics, GIGA-R and Faculty of Veterinary Medicine, Universite de Liège (B34), avenue de l'Hôpital 1, 4000, Liège, Belgium.
Edouard LouisUnit of Animal Genomics, GIGA-R and Faculty of Veterinary Medicine, Universite de Liège (B34), avenue de l'Hôpital 1, 4000, Liège, Belgium.
Emilie TheatreUnit of Animal Genomics, GIGA-R and Faculty of Veterinary Medicine, Universite de Liège (B34), avenue de l'Hôpital 1, 4000, Liège, Belgium.
Stephanie DahanImmunology Institute, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Yukihide MomozawaLaboratory for Genotyping Development, Center for Integrative Medical Sciences, RIKEN 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan.
Michel GeorgesUnit of Animal Genomics, GIGA-R and Faculty of Veterinary Medicine, Universite de Liège (B34), avenue de l'Hôpital 1, 4000, Liège, Belgium.
Garabet YeretssianImmunology Institute, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Philippe GrosMcGill Center for the Study of Complex Traits, Department of Human Genetics, Department of Biochemistry, McGill University, 3649 Sir William Osler Promenade, Montreal, QC, Canada, H3G 0B1. philippe.gros@mcgill.ca.
McGill University · CAUniversity of Liège · BECentre Hospitalier de l’Université de Montréal · CARIKEN Center for Integrative Medical Sciences · JPBG Medicine (United States) · USLeona M. and Harry B. Helmsley Charitable Trust · USMcGill Genome Centre · CATisch Hospital · USUniversité de Montréal · CA
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inflammatory bowel disease (IBD) involves interaction between host genetic factors and environmental triggers. CCDC88B maps within one IBD risk locus on human chromosome 11q13. Here we show that CCDC88B protein increases in the colon during intestinal injury, concomitant with an influx of CCDC88B
Indexed as
AnimalsCarrier ProteinsColitisColonCrohn DiseaseDextran SulfateGene Expression RegulationHomeodomain ProteinsHumansInflammatory Bowel DiseasesLipopolysaccharide ReceptorsMaleMice, Inbred C57BLMice, Mutant StrainsMyeloid CellsPolymorphism, Single NucleotideCarrier ProteinsCCDC88B protein, humancoiled-coil domain containing 88B protein, mouseDextran SulfateHomeodomain ProteinsLipopolysaccharide ReceptorsRAG-1 protein
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.