ArticleScientific reports2017
Interfering with the high-affinity interaction between wheat amylase trypsin inhibitor CM3 and toll-like receptor 4: in silico and biosensor-based studies.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 39 citations in OpenAlex.
- In Vitro TLR4 Stimulating Bioactivities of Amylase/Trypsin-Inhibitors from Wheat (Foods (Basel, Switzerland) · 2026Article
- Lower Diversity of Amylase-Trypsin Inhibitors andJournal of agricultural and food chemistry · 2025Article
- No correlation between amylase/trypsin-inhibitor content and amylase inhibitory activity in hexaploid and tetraploid wheat species.Current research in food science · 2023Article
- Digestibility of wheat alpha-amylase/trypsin inhibitors using a caricain digestive supplement.Frontiers in nutrition · 2022Article
- Assessing the effects of a novel biostimulant to enhance leafminer resistance and plant growth on common bean.Scientific reports · 2021Article
- Genetic architecture underlying the expression of eight α-amylase trypsin inhibitors.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2021Article
- Intestinal Exposure to Food-Derived Protease Inhibitors: Digestion Physiology- and Gut Health-Related Effects.Healthcare (Basel, Switzerland) · 2021Review
- Wheat ATIs: Characteristics and Role in Human Disease.Frontiers in nutrition · 2021Review
- Article
- Wheat-induced food allergy in childhood: ancient grains seem no way out.European journal of nutrition · 2020Article
- Reduction of Allergenic Potential in Bread Wheat RNAi Transgenic Lines Silenced forInternational journal of molecular sciences · 2020Article
- Structure/activity virtual screening and in vitro testing of small molecule inhibitors of 8-hydroxy-5-deazaflavin:NADPH oxidoreductase from gut methanogenic bacteria.Scientific reports · 2020Article
- Sourdough Fermentation Degrades Wheat Alpha-Amylase/Trypsin Inhibitor (ATI) and Reduces Pro-Inflammatory Activity.Foods (Basel, Switzerland) · 2020Article
- Article
- Purification and Functional Characterization of the Chloroform/Methanol-Soluble Protein 3 (CM3) FromFrontiers in nutrition · 2020Article
- Identification of a Killer Toxin fromToxins · 2019Article
- Wheat ATI CM3, CM16 and 0.28 Allergens Produced inPlants (Basel, Switzerland) · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Wheat amylase/trypsin bi-functional inhibitors (ATIs) are protein stimulators of innate immune response, with a recently established role in promoting both gastrointestinal and extra-gastrointestinal inflammatory syndromes. These proteins have been reported to trigger downstream intestinal inflammation upon activation of TLR4, a member of the Toll-like family of proteins that activates signalling pathways and induces the expression of immune and pro-inflammatory genes. In this study, we demonstrated the ability of ATI to directly interact with TLR4 with nanomolar affinity, and we kinetically and structurally characterized the interaction between these macromolecules by means of a concerted approach based on surface plasmon resonance binding analyses and computational studies. On the strength of these results, we designed an oligopeptide capable of preventing the formation of the complex between ATI and the receptor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.