Evidence map›Paper›PMID 29030599›Full record

SynthesisNature communications2017

Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity.

Peter K Joshi, Nicola Pirastu, Katherine A Kentistou, Krista Fischer, Edith Hofer, Katharina E Schraut, David W Clark, Teresa Nutile, Catriona L K Barnes, Paul R H J Timmers and 103 more

Open access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
97citing papers in PubMed, 4 pooled it
17.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

97 citing papers in PubMed, 4 syntheses or guidelines pooled it, 175 citations in OpenAlex.

  1. Pooled it
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  16. The association of a polygenic lifespan score with the risk of common age-related diseases and mortality.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025
    Article
  17. Article
  18. Prolonged exposure to leisure screen time notably accelerates biological aging: Evidence from observational studies and genetic associations.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Observational
  19. Article
  20. Article

37 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

113 authors at 20 institutions in 15 countries.

Peter K JoshiCentre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, EH8 9AG, UK. peter.joshi@ed.ac.uk.ORCID http://orcid.org/0000-0002-6361-5059
Nicola PirastuCentre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, EH8 9AG, UK.ORCID http://orcid.org/0000-0002-5363-3886
Katherine A KentistouCentre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, EH8 9AG, UK.
Krista FischerEstonian Genome Center, University of Tartu, University of Tartu, Tartu, 51010, Estonia.
Edith HoferClinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, 8036, Austria.
Katharina E SchrautCentre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, EH8 9AG, UK.
David W ClarkCentre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, EH8 9AG, UK.
Teresa NutileInstitute of Genetics and Biophysics "A. Buzzati-Traverso" - CNR, Naples, 80131, Italy.
Catriona L K BarnesCentre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, EH8 9AG, UK.
Paul R H J TimmersCentre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, EH8 9AG, UK.
Xia ShenCentre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, EH8 9AG, UK.ORCID http://orcid.org/0000-0003-4390-1979
Ilaria GandinDepartment of Medical Sciences, University of Trieste, Trieste, 34100, Italy.
Aaron F McDaidInstitute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne, 1010, Switzerland.ORCID http://orcid.org/0000-0002-5209-8869
Thomas Folkmann HansenInstitute of Biological Psychiatry, Mental Health Centre Sct. Hans, Mental Health Services Copenhagen, Roskilde, DK-4000, Denmark.ORCID http://orcid.org/0000-0001-6703-7762
Scott D GordonQIMR Berghofer Institute of Medical Research, Brisbane, QLD, 4006, Australia.
Franco GiulianiniDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, 02215, USA.
Thibaud S BoutinMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK.
Abdel AbdellaouiNetherlands Twin Register, Department of Biological Psychology, Vrije Universiteit, Amsterdam, Amsterdam Public Health Institute (APH), Amsterdam, 1081BT, Netherlands.
Wei ZhaoDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA.
Carolina Medina-GomezDepartment of Internal Medicine, Erasmus University Medical Center, Rotterdam, 3015 CN, Netherlands.ORCID http://orcid.org/0000-0001-7999-5538
Traci M BartzCardiovascular Health Research Unit, Departments of Biostatistics and Medicine, University of Washington, Seattle, WA, 98101, USA.
Stella TrompetSection of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, Leiden, 2300RC, The Netherlands.
Leslie A LangeDepartment of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, 80045, USA.
Laura RaffieldDepartment of Genetics, University of North Carolina, Chapel Hill, NC, 27599, USA.
Ashley van der SpekDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015 CN, Netherlands.
Tessel E GaleslootDepartment for Health Evidence, Radboud Institute for Health Sciences, Radboud university medical center, Nijmegen, 6500 HB, The Netherlands.
Petroula ProitsiMRC Unit for Lifelong Health & Ageing at UCL, University College London, London, WC1B 5JU, UK.
Lisa R YanekDepartment of Medicine, GeneSTAR Research Program, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.ORCID http://orcid.org/0000-0001-7117-1075
Lawrence F BielakDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA.
Antony PaytonCentre for Epidemiology, Division of Population Health, Health Services Research & Primary Care, The University of Manchester, Manchester, Greater, Manchester, M13 9PL, UK.
Federico MurgiaCenter for Biomedicine, European Academy of Bozen/Bolzano (EURAC), (Affiliated Institute of the University of Lübeck, Lübeck, Germany), Bolzano, 39100, Italy.ORCID http://orcid.org/0000-0002-3608-845X
Maria Pina ConcasInstitute of Genetic and Biomedical Research - Support Unity, National Research Council of Italy, Sassari, 07100, Italy.
Ginevra BiinoInstitute of Molecular Genetics, National Research Council of Italy, Pavia, 27100, Italy.ORCID http://orcid.org/0000-0002-9936-946X
Salman M TajuddinLaboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore City, MD, 21224, USA.ORCID http://orcid.org/0000-0002-7919-8528
Ilkka SeppäläDepartment of Clinical Chemistry, Fimlab Laboratories and Faculty of Medicine and Life Sciences, University of Tampere, Tampere, 33014, Finland.ORCID http://orcid.org/0000-0002-5595-2573
Najaf AminDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015 CN, Netherlands.
Eric BoerwinkleHealth Science Center at Houston, UTHealth School of Public Health, University of Texas, Houston, TX, 77030, USA.
Anders D BørglumiPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, DK-8000, Denmark.
Archie CampbellCentre for Genomic & Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.
Ellen W DemerathDivision of Epidemiology & Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, 55454, USA.
Ilja DemuthCharité Research Group on Geriatrics, Charité, Universitätsmedizin Berlin, Berlin, 13347, Germany.
Jessica D FaulSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, 48014, USA.
Ian FordRobertson Center for biostatistics, University of Glasgow, Glasgow, G12 8QQ, UK.
Alessandro GialluisiIRCCS Neuromed, Pozzilli (IS), 86077, Italy.ORCID http://orcid.org/0000-0002-7388-4463
Martin GögeleCenter for Biomedicine, European Academy of Bozen/Bolzano (EURAC), (Affiliated Institute of the University of Lübeck, Lübeck, Germany), Bolzano, 39100, Italy.
MariaElisa GraffDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, 27514, USA.
Aroon HingoraniInstitute of Cardiovascular Science, University College London, London, WC1E 6BT, UK.
Jouke-Jan HottengaNetherlands Twin Register, Department of Biological Psychology, Vrije Universiteit, Amsterdam, Amsterdam Public Health Institute (APH), Amsterdam, 1081BT, Netherlands.
David M HougaardiPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, DK-8000, Denmark.ORCID http://orcid.org/0000-0001-5928-3517
Mikko A HurmeDepartment of Microbiology and Immunology, Fimlab Laboratories and Faculty of Medicine and Life Sciences, University of Tampere, Tampere, 33014, Finland.
M Arfan IkramDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015 CN, Netherlands.ORCID http://orcid.org/0000-0003-0372-8585
Marja JylhäGerontology Research Center, Tampere, Finland, Faculty of Social Sciences, University of Tampere, Tampere, 33104, Finland.
Diana KuhMRC Unit for Lifelong Health & Ageing at UCL, University College London, London, WC1B 5JU, UK.
Lannie LigthartNetherlands Twin Register, Department of Biological Psychology, Vrije Universiteit, Amsterdam, Amsterdam Public Health Institute (APH), Amsterdam, 1081BT, Netherlands.
Christina M LillGenetic and Molecular Epidemiology Group, Institute of Neurogenetics, University of Lübeck, 23562, Lübeck, Germany.ORCID http://orcid.org/0000-0002-2805-1307
Ulman LindenbergerCenter for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, 14195, Germany.
Thomas LumleyDepartment of Statistics, University of Auckland, Auckland, 1010, New Zealand.
Reedik MägiEstonian Genome Center, University of Tartu, University of Tartu, Tartu, 51010, Estonia.
Pedro Marques-VidalDepartment of Medicine, Internal Medicine, Lausanne University Hospital, Lausanne, 1011, Switzerland.ORCID http://orcid.org/0000-0002-4548-8500
Sarah E MedlandQIMR Berghofer Institute of Medical Research, Brisbane, QLD, 4006, Australia.ORCID http://orcid.org/0000-0003-1382-380X
Lili MilaniEstonian Genome Center, University of Tartu, University of Tartu, Tartu, 51010, Estonia.ORCID http://orcid.org/0000-0002-5323-3102
Reka NagyMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK.
William E R OllierDivision of Population Health, Health Services Research & Primary Care, School of Health Sciences, Manchester Academic Health Science Centre, University of Manchester, Manchester, Greater Manchester, M13 9PL, UK.
Patricia A PeyserDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA.
Peter P PramstallerCenter for Biomedicine, European Academy of Bozen/Bolzano (EURAC), (Affiliated Institute of the University of Lübeck, Lübeck, Germany), Bolzano, 39100, Italy.
Paul M RidkerDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, 02215, USA.
Fernando RivadeneiraDepartment of Internal Medicine, Erasmus University Medical Center, Rotterdam, 3015 CN, Netherlands.ORCID http://orcid.org/0000-0001-9435-9441
Daniela RuggieroInstitute of Genetics and Biophysics "A. Buzzati-Traverso" - CNR, Naples, 80131, Italy.
Yasaman SabaAustrian Stroke Prevention Study, Institute of Molecular Biology and Biochemistry, Centre for Molecular Medicine, Medical University of Graz, Graz, 8010, Austria.
Reinhold SchmidtClinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, 8036, Austria.
Helena SchmidtAustrian Stroke Prevention Study, Institute of Molecular Biology and Biochemistry, Centre for Molecular Medicine, Medical University of Graz, Graz, 8010, Austria.
P Eline SlagboomSection of Molecular Epidemiology, Department of medical statistics, Leiden University Medical Center, Leiden, 2300RC, The Netherlands.
Blair H SmithDivision of Population Health Sciences, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY, UK.ORCID http://orcid.org/0000-0002-5362-9430
Jennifer A SmithDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA.ORCID http://orcid.org/0000-0002-3575-5468
Nona SotoodehniaCardiovascular Health Research Unit, Division of Cardiology, University of Washington, Seattle, WA, 98101, USA.
Elisabeth Steinhagen-ThiessenCharité Research Group on Geriatrics, Charité, Universitätsmedizin Berlin, Berlin, 13347, Germany.
Frank J A van RooijDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015 CN, Netherlands.
André L VerbeekDepartment for Health Evidence, Radboud Institute for Health Sciences, Radboud university medical center, Nijmegen, 6500 HB, The Netherlands.
Sita H VermeulenDepartment for Health Evidence, Radboud Institute for Health Sciences, Radboud university medical center, Nijmegen, 6500 HB, The Netherlands.
Peter VollenweiderDepartment of Medicine, Internal Medicine, Lausanne University Hospital, Lausanne, 1011, Switzerland.
Yunpeng WangiPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, DK-8000, Denmark.
Thomas WergeInstitute of Biological Psychiatry, Mental Health Centre Sct. Hans, Mental Health Services Copenhagen, Roskilde, DK-4000, Denmark.
John B WhitfieldQIMR Berghofer Institute of Medical Research, Brisbane, QLD, 4006, Australia.ORCID http://orcid.org/0000-0002-1103-0876
Alan B ZondermanLaboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore City, MD, 21224, USA.
Terho LehtimäkiDepartment of Clinical Chemistry, Fimlab Laboratories and Faculty of Medicine and Life Sciences, University of Tampere, Tampere, 33014, Finland.
Michele K EvansLaboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore City, MD, 21224, USA.
Mario PirastuInstitute of Genetic and Biomedical Research - Support Unity, National Research Council of Italy, Sassari, 07100, Italy.
Christian FuchsbergerCenter for Biomedicine, European Academy of Bozen/Bolzano (EURAC), (Affiliated Institute of the University of Lübeck, Lübeck, Germany), Bolzano, 39100, Italy.
Lars BertramLübeck Interdisciplinary Platform for Genome Analytics, Institutes of Neurogenetics & Cardiogenetics, University of Lübeck, Lübeck, 23562, Germany.
Neil PendletonDivision of Neuroscience and Experimental Psychology, School of Biological Sciences, Manchester Academic Health Science Centre, University of Manchester, Manchester, Greater Manchester, M13 9PL, UK.ORCID http://orcid.org/0000-0003-0794-2386
Sharon L R KardiaDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA.
Marina CiulloInstitute of Genetics and Biophysics "A. Buzzati-Traverso" - CNR, Naples, 80131, Italy.
Diane M BeckerDepartment of Medicine, GeneSTAR Research Program, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
Andrew WongMRC Unit for Lifelong Health & Ageing at UCL, University College London, London, WC1B 5JU, UK.ORCID http://orcid.org/0000-0003-2079-4779
Bruce M PsatyCardiovascular Health Research Unit, Departments of Epidemiology, Medicine and Health Services, University of Washington, Seattle, WA, 98101, USA.
Cornelia M van DuijnDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015 CN, Netherlands.
James G WilsonDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, 39216, USA.
J Wouter JukemaDepartment of Cardiology, Leiden University Medical Center, Leiden, 2300RC, The Netherlands.ORCID http://orcid.org/0000-0002-3246-8359
Lambertus KiemeneyDepartment for Health Evidence, Radboud Institute for Health Sciences, Radboud university medical center, Nijmegen, 6500 HB, The Netherlands.
André G UitterlindenDepartment of Internal Medicine, Erasmus University Medical Center, Rotterdam, 3015 CN, Netherlands.
Nora FranceschiniDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, 27514, USA.
Kari E NorthDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, 27514, USA.
David R WeirSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, 48014, USA.
Andres MetspaluEstonian Genome Center, University of Tartu, University of Tartu, Tartu, 51010, Estonia.
Dorret I BoomsmaNetherlands Twin Register, Department of Biological Psychology, Vrije Universiteit, Amsterdam, Amsterdam Public Health Institute (APH), Amsterdam, 1081BT, Netherlands.
Caroline HaywardMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK.ORCID http://orcid.org/0000-0002-9405-9550
Daniel ChasmanDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, 02215, USA.
Nicholas G MartinQIMR Berghofer Institute of Medical Research, Brisbane, QLD, 4006, Australia.
Naveed SattarBHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, G12 8TD, UK.
Harry CampbellCentre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, EH8 9AG, UK.
Tōnu EskoEstonian Genome Center, University of Tartu, University of Tartu, Tartu, 51010, Estonia.
Zoltán KutalikInstitute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne, 1010, Switzerland.
James F WilsonCentre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, EH8 9AG, UK.ORCID http://orcid.org/0000-0001-5751-9178
Erasmus MC · NLUniversity of Michigan · USUniversity of Edinburgh · GBWestern General Hospital · GBEurac Research · ITMedical University of Graz · ATQIMR Berghofer Medical Research Institute · AURadboud University Nijmegen · NLUniversity of North Carolina at Chapel Hill · USUniversity of Tartu · EEVrije Universiteit Amsterdam · NLBrigham and Women's Hospital · USLeiden University Medical Center · NLManchester Academic Health Science Centre · GBMRC Unit for Lifelong Health and Ageing · GBNational Institutes of Health · USTampere University · FIInstitute of Genetic and Biomedical Research · ITInstitute of Genetics and Biophysics · ITIstituto Neurologico Mediterraneo · IT

Funding

Tracking and Evaluation CoreU54GM115428 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI MASON, SARAH · 2016 to 2025
$38.2M
CHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5M
Rare variants and NHLBI traits in deeply phenotyped cohortsR01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2014 to 2016
$8.9M
CHS research resources for the cardiovascular health of older adultsU01HL130114 · NHLBI · UNIVERSITY OF WASHINGTON · PI BURKE, GREGORY L, KRONMAL, RICHARD A · 2016 to 2019
$6.6M
Rare variants and NHLBI traits in deeply phenotyped cohortsU01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2017 to 2018
$5.6M
The Women's Health Study: Infrastructure Support for Continued Cohort Follow-upUM1CA182913 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E., LEE, I-MIN · 2014 to 2018
$4.0M
The Genetic Epidemiology of Heart, Lung, and Blood TraitsTraining Grant (GenHLB)T32HL129982 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Christy Leigh Avery, KAREN L. MOHLKE · 2016 to 2026
$3.8M
Biotechnology and Biological Sciences Research Council BB/F022441/1Medical Research Council G0100594Medical Research Council G0600237Medical Research Council G0900753Medical Research Council G0901461Medical Research Council MC_PC_14126Medical Research Council MC_PC_U127561128Medical Research Council MC_QA137853Medical Research Council MC_UU_12019/1Medical Research Council MR/K002279/1Medical Research Council MR/K026992/1Medical Research Council MR/N005813/1NCI NIH HHS UM1 CA182913NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL120393NHLBI NIH HHS T32 HL129982NHLBI NIH HHS U01 HL120393NHLBI NIH HHS U01 HL130114NIGMS NIH HHS U54 GM115428Wellcome Trust
6 · The paper itself

Abstract

Genomic analysis of longevity offers the potential to illuminate the biology of human aging. Here, using genome-wide association meta-analysis of 606,059 parents' survival, we discover two regions associated with longevity (HLA-DQA1/DRB1 and LPA). We also validate previous suggestions that APOE, CHRNA3/5, CDKN2A/B, SH2B3 and FOXO3A influence longevity. Next we show that giving up smoking, educational attainment, openness to new experience and high-density lipoprotein (HDL) cholesterol levels are most positively genetically correlated with lifespan while susceptibility to coronary artery disease (CAD), cigarettes smoked per day, lung cancer, insulin resistance and body fat are most negatively correlated. We suggest that the effect of education on lifespan is principally mediated through smoking while the effect of obesity appears to act via CAD. Using instrumental variables, we suggest that an increase of one body mass index unit reduces lifespan by 7 months while 1 year of education adds 11 months to expected lifespan.Variability in human longevity is genetically influenced. Using genetic data of parental lifespan, the authors identify associations at HLA-DQA/DRB1 and LPA and find that genetic variants that increase educational attainment have a positive effect on lifespan whereas increasing BMI negatively affects lifespan.

Indexed as

Life StyleAllelesBody Mass IndexCoronary DiseaseEducationGenetic Predisposition to DiseaseGenome-Wide Association StudyHLA-DQ alpha-ChainsHLA-DRB1 ChainsHumansInsulin ResistanceLipoprotein(a)Lipoproteins, HDLLongevityLung NeoplasmsObesityHLA-DQA1 antigenHLA-DQ alpha-ChainsHLA-DRB1 ChainsLipoprotein(a)Lipoproteins, HDL

Identifiers

PMID29030599
PMCPMC5715013
OpenAlexW2750901335

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.