Evidence map›Paper›PMID 29030552›Full record

ArticleNature communications2017

BAD-LAMP controls TLR9 trafficking and signalling in human plasmacytoid dendritic cells.

Alexis Combes, Voahirana Camosseto, Prudence N'Guessan, Rafael J Argüello, Julie Mussard, Christophe Caux, Nathalie Bendriss-Vermare, Philippe Pierre, Evelina Gatti

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 79 citations in OpenAlex.

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  5. Induction of the ISR by AB5 subtilase cytotoxin drives type-I IFN expression in pDCs via STING activation.Proceedings of the National Academy of Sciences of the United States of America · 2025
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  9. Unleashing viral mimicry: A combinatorial strategy to enhance the efficacy of PARP7 inhibitors.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025
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  15. Article
  16. Harnessing innate immune pathways for therapeutic advancement in cancer.Signal transduction and targeted therapy · 2024
    Review
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Alexis CombesAix Marseille Université, CNRS, INSERM, CIML, 13288, Marseille cedex 9, France.
Voahirana CamossetoAix Marseille Université, CNRS, INSERM, CIML, 13288, Marseille cedex 9, France.
Prudence N'GuessanAix Marseille Université, CNRS, INSERM, CIML, 13288, Marseille cedex 9, France.
Rafael J ArgüelloAix Marseille Université, CNRS, INSERM, CIML, 13288, Marseille cedex 9, France.
Julie MussardCentre Léon Berard, 69373, LYON cedex 08, France.
Christophe CauxCentre Léon Berard, 69373, LYON cedex 08, France.
Nathalie Bendriss-VermareCentre Léon Berard, 69373, LYON cedex 08, France.
Philippe PierreAix Marseille Université, CNRS, INSERM, CIML, 13288, Marseille cedex 9, France.ORCID http://orcid.org/0000-0003-0863-8255
Evelina GattiAix Marseille Université, CNRS, INSERM, CIML, 13288, Marseille cedex 9, France. gatti@ciml.univ-mrs.fr.
Centre National de la Recherche Scientifique · FRUniversité Claude Bernard Lyon 1 · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Toll-like receptors (TLR) are essential components of the innate immune system. Several accessory proteins, such as UNC93B1, are required for transport and activation of nucleic acid sensing Toll-like receptors in endosomes. Here, we show that BAD-LAMP (LAMP5) controls TLR9 trafficking to LAMP1

Indexed as

Signal TransductionCell Line, TumorCells, CulturedDendritic CellsEndosomesHumansInterferon Type ILysosomal-Associated Membrane Protein 1Lysosomal-Associated Membrane Protein 2Lysosomal Membrane ProteinsMicroscopy, ConfocalNF-kappa BProtein TransportRNA InterferenceToll-Like Receptor 9Transforming Growth Factor betaInterferon Type ILAMP1 protein, humanLAMP5 protein, humanLysosomal-Associated Membrane Protein 1Lysosomal-Associated Membrane Protein 2Lysosomal Membrane ProteinsNF-kappa BToll-Like Receptor 9Transforming Growth Factor betaVAMP3 protein, humanVesicle-Associated Membrane Protein 3

Identifiers

PMID29030552
PMCPMC5640662
OpenAlexW2763770180

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.