Evidence map›Paper›PMID 29030483›Full record

ArticleThe EMBO journal2017

RBPJ/CBF1 interacts with L3MBTL3/MBT1 to promote repression of Notch signaling via histone demethylase KDM1A/LSD1.

Tao Xu, Sung-Soo Park, Benedetto Daniele Giaimo, Daniel Hall, Francesca Ferrante, Diana M Ho, Kazuya Hori, Lucas Anhezini, Iris Ertl, Marek Bartkuhn and 17 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The EMBO journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 85 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
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  7. Article
  8. Article
  9. Review
  10. Notch Signaling in Drosophila Tumor Models.Advances in experimental medicine and biology · 2025
    Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. lncRNAProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 5 institutions in 3 countries.

Tao XuDepartment of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.
Sung-Soo ParkDepartment of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.
Benedetto Daniele GiaimoInstitute of Biochemistry, University of Giessen, Giessen, Germany.
Daniel HallDepartment of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Francesca FerranteInstitute of Biochemistry, University of Giessen, Giessen, Germany.
Diana M HoDepartment of Cell Biology, Harvard Medical School, Boston, MA, USA.
Kazuya HoriDepartment of Cell Biology, Harvard Medical School, Boston, MA, USA.
Lucas AnheziniLife Sciences Institute, University of Michigan, Ann Arbor, MI, USA.
Iris ErtlCancer and Human Molecular Genetics, Bellvitge Biomedical Research Institute, L'Hospitalet de Llobregat, Barcelona, Spain.
Marek BartkuhnInstitute for Genetics, University of Giessen, Giessen, Germany.
Honglai ZhangDepartment of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.
Eléna MilonDepartment of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.
Kimberly HaDepartment of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.
Kevin P ConlonDepartment of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.
Rork KuickCenter for Cancer Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Brandon GovindarajooDepartment of Computational Medicine & Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
Yang ZhangDepartment of Computational Medicine & Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
Yuqing SunDepartment of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.
Yali DouDepartment of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.
Venkatesha BasrurDepartment of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.
Kojo Sj Elenitoba-JohnsonDepartment of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.
Alexey I NesvizhskiiDepartment of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.
Julian CeronCancer and Human Molecular Genetics, Bellvitge Biomedical Research Institute, L'Hospitalet de Llobregat, Barcelona, Spain.
Cheng-Yu LeeLife Sciences Institute, University of Michigan, Ann Arbor, MI, USA.
Tilman BorggrefeInstitute of Biochemistry, University of Giessen, Giessen, Germany.
Rhett A KovallDepartment of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Jean-François RualDepartment of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA jrual@umich.edu.ORCID 0000-0003-4465-8819
University of Michigan · USJustus-Liebig-Universität Gießen · DEBellvitge University Hospital · ESHarvard University · USUniversity of Cincinnati Medical Center · US

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI THEODORE S LAWRENCE · 1988 to 2026
$178.2M
University of Michigan Postbaccalaureate Research Education Program (UM PREP)R25GM086262 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ALLEN, BENJAMIN · 2009 to 2024
$6.1M
COMPUTATIONAL TOOLS FOR MASS SPECTROMETRY-BASED INTERACTOME DATAR01GM094231 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Alexey I Nesvizhskii · 2010 to 2026
$5.4M
University of Michigan Proteogenomics Data Analysis CenterU24CA210967 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHINNAIYAN, ARUL M, DHANASEKARAN, SARAVANA M · 2016 to 2020
$4.1M
CHARACTERIZATION OF THE MOLECULAR INTERPLAY BETWEEN HOXA9 AND OGT IN ACUTE LEUKEMIAR01CA187903 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI RUAL, JEAN-FRANCOIS M · 2015 to 2019
$1.8M
Molecular mechanisms of transcriptional regulation in the Notch pathwayR01CA178974 · NCI · UNIVERSITY OF CINCINNATI · PI KOVALL, RHETT ALLEN · 2013 to 2017
$1.6M
NCI NIH HHS P30 CA046592NCI NIH HHS R01 CA178974NCI NIH HHS R01 CA187903NCI NIH HHS U24 CA210967NIGMS NIH HHS R01 GM094231NIGMS NIH HHS R25 GM086262
6 · The paper itself

Abstract

Notch signaling is an evolutionarily conserved signal transduction pathway that is essential for metazoan development. Upon ligand binding, the Notch intracellular domain (NOTCH ICD) translocates into the nucleus and forms a complex with the transcription factor RBPJ (also known as CBF1 or CSL) to activate expression of Notch target genes. In the absence of a Notch signal, RBPJ acts as a transcriptional repressor. Using a proteomic approach, we identified L3MBTL3 (also known as MBT1) as a novel RBPJ interactor. L3MBTL3 competes with NOTCH ICD for binding to RBPJ In the absence of NOTCH ICD, RBPJ recruits L3MBTL3 and the histone demethylase KDM1A (also known as LSD1) to the enhancers of Notch target genes, leading to H3K4me2 demethylation and to transcriptional repression. Importantly,

Indexed as

AnimalsBiological EvolutionCaenorhabditis elegansCell Line, TumorConserved SequenceDNA-Binding ProteinsDrosophila melanogasterDrosophila ProteinsGene Expression RegulationHistone DemethylasesHistonesHumansImmunoglobulin J Recombination Signal Sequence-Binding ProteinNeurogliaProtein BindingProtein DomainsDNA-Binding ProteinsDrosophila ProteinsHistone DemethylasesHistonesImmunoglobulin J Recombination Signal Sequence-Binding ProteinKDM1A protein, humanL3MBTL3 protein, humanN protein, DrosophilaRBPJ protein, humanReceptors, NotchKDM1AL3MBTL3Notch signalingRBPJ

Identifiers

PMID29030483
PMCPMC5666606
OpenAlexW2762785612

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.