ArticleGenome research2017
Single-cell gene expression analysis reveals regulators of distinct cell subpopulations among developing human neurons.
Article in Genome research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Single cell analysis of developing Merkel cells reveals the emergence of non-coding RNA biotypes as a hallmark of terminal differentiation.Cell death and differentiation · 2026Article
- BRD1 haploinsufficiency alters early neuronal programming and disrupts maturation in human induced glutamatergic neurons.Research square · 2026Article
- Cancer Stemness Online: A Resource for Investigating Cancer Stemness and Associations with Immune Response.Genomics, proteomics & bioinformatics · 2024Article
- SCTC: inference of developmental potential from single-cell transcriptional complexity.Nucleic acids research · 2024Article
- RNA structure profiling at single-cell resolution reveals new determinants of cell identity.Nature methods · 2024Article
- scGIR: deciphering cellular heterogeneity via gene ranking in single-cell weighted gene correlation networks.Briefings in bioinformatics · 2024Article
- Article
- Forskolin-driven conversion of human somatic cells into induced neurons through regulation of the cAMP-CREB1-JNK signaling.Theranostics · 2024Article
- Cell Features Reconstruction from Gene Association Network of Single Cell.Interdisciplinary sciences, computational life sciences · 2023Article
- Accurate integration of multiple heterogeneous single-cell RNA-seq data sets by learning contrastive biological variation.Genome research · 2023Article
- Brain Neural Progenitors are New Predictive Biomarkers for Breast Cancer Hormonotherapy.Cancer research communications · 2022Article
- Single-cell transcriptomics identifies master regulators of neurodegeneration in SOD1 ALS iPSC-derived motor neurons.Stem cell reports · 2021Article
- Single-cell analysis reveals dynamic changes of neural cells in developing human spinal cord.EMBO reports · 2021Article
- Robust integration of multiple single-cell RNA sequencing datasets using a single reference space.Nature biotechnology · 2021Article
- scGET: Predicting Cell Fate Transition During Early Embryonic Development by Single-cell Graph Entropy.Genomics, proteomics & bioinformatics · 2021Article
- A comprehensive survey of regulatory network inference methods using single cell RNA sequencing data.Briefings in bioinformatics · 2021Review
- c-CSN: Single-cell RNA Sequencing Data Analysis by Conditional Cell-specific Network.Genomics, proteomics & bioinformatics · 2021Article
- An old weapon with a new function: PIWI-interacting RNAs in neurodegenerative diseases.Translational neurodegeneration · 2021Review
- Overview of PAX gene family: analysis of human tissue-specific variant expression and involvement in human disease.Human genetics · 2021Review
- Article
Corrections and comments
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8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The stochastic dynamics and regulatory mechanisms that govern differentiation of individual human neural precursor cells (NPC) into mature neurons are currently not fully understood. Here, we used single-cell RNA-sequencing (scRNA-seq) of developing neurons to dissect/identify NPC subtypes and critical developmental stages of alternative lineage specifications. This study comprises an unsupervised, high-resolution strategy for identifying cell developmental bifurcations, tracking the stochastic transcript kinetics of the subpopulations, elucidating regulatory networks, and finding key regulators. Our data revealed the bifurcation and developmental tracks of the two NPC subpopulations, and we captured an early (24 h) transition phase that leads to alternative neuronal specifications. The consequent up-regulation and down-regulation of stage- and subpopulation-specific gene groups during the course of maturation revealed biological insights with regard to key regulatory transcription factors and lincRNAs that control cellular programs in the identified neuronal subpopulations.
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