Evidence map›Paper›PMID 29030467›Full record

ReviewJournal of the American Society of Nephrology : JASN2018

Metabolic Acidosis and Subclinical Metabolic Acidosis in CKD.

Kalani L Raphael

Open access · greenAbstract readReview
In one paragraph

Review in Journal of the American Society of Nephrology : JASN, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 1 synthesis or guideline pooled it, 113 citations in OpenAlex.

  1. Effects of dietary interventions for metabolic acidosis in chronic kidney disease: a systematic review and meta-analysis.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025
    Pooled it
  2. Effect of Bicarbonate on Net Acid Excretion, Blood Pressure, and Metabolism in Patients With and Without CKD: The Acid Base Compensation in CKD Study.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2021
    Trial
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  7. Adjusting Autonomic Physiology with Diet and Minerals to Improve Health.Integrative medicine (Encinitas, Calif.) · 2026
    Review
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  20. Chronic kidney disease.Nature reviews. Disease primers · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Kalani L RaphaelVeterans Affairs Salt Lake City Health Care System and Division of Nephrology and Hypertension, Department of Internal Medicine, University of Utah, Salt Lake City, Utah kalani.raphael@hsc.utah.edu.
University of Utah · US

Funding

Oral Sodium Bicarbonate to Slow Chronic Kidney Disease ProgressionU01DK099933 · NIDDK · UNIVERSITY OF UTAH · PI CHEUNG, ALFRED K, RAPHAEL, KALANI LUKELA · 2013 to 2018
$1.5M
Investigations of the optimum serum bicarbonate level in renal diseaseIK2CX000537 · VA · VA SALT LAKE CITY HEALTHCARE SYSTEM · PI RAPHAEL, KALANI LUKELA · 2012 to 2016
–
CSRD VA IK2 CX000537NIDDK NIH HHS U01 DK099933
6 · The paper itself

Abstract

Metabolic acidosis is not uncommon in CKD and is linked with bone demineralization, muscle catabolism, and higher risks of CKD progression and mortality. Clinical practice guidelines recommend maintaining serum total CO

Indexed as

Asymptomatic DiseasesAcidosisAcidsAlkaliesBone Demineralization, PathologicCarbon DioxideGlomerular Filtration RateHumansRenal Insufficiency, ChronicRisk FactorsSodium BicarbonateAcidsAlkaliesCarbon DioxideSodium Bicarbonateacidosischronic kidney diseasechronic metabolic acidosisESRDmortality

Identifiers

PMID29030467
PMCPMC5791070
OpenAlexW2762302859

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.