Evidence map›Paper›PMID 29030453›Full record

ArticleNeurology2017

GABA alterations in pediatric sport concussion.

Seth D Friedman, Andrew V Poliakov, Christopher Budech, Dennis W W Shaw, David Breiger, Thomas Jinguji, Brian Krabak, David Coppel, Tressa Mattioli Lewis, Samuel Browd and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 3 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 3 syntheses or guidelines pooled it, 22 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Seth D FriedmanFrom the Seattle Children's Hospital and Research Institute (S.D.F., A.V.P., C.B., D.W.W.S., D.B., T.J., B.K., D.C, T.M.L., S.B., J.G.O.) and University of Washington (D.W.W.S., D.B., T.J., B.K., D.C., S.B., J.G.O.), Seattle.
Andrew V PoliakovFrom the Seattle Children's Hospital and Research Institute (S.D.F., A.V.P., C.B., D.W.W.S., D.B., T.J., B.K., D.C, T.M.L., S.B., J.G.O.) and University of Washington (D.W.W.S., D.B., T.J., B.K., D.C., S.B., J.G.O.), Seattle.
Christopher BudechFrom the Seattle Children's Hospital and Research Institute (S.D.F., A.V.P., C.B., D.W.W.S., D.B., T.J., B.K., D.C, T.M.L., S.B., J.G.O.) and University of Washington (D.W.W.S., D.B., T.J., B.K., D.C., S.B., J.G.O.), Seattle.
Dennis W W ShawFrom the Seattle Children's Hospital and Research Institute (S.D.F., A.V.P., C.B., D.W.W.S., D.B., T.J., B.K., D.C, T.M.L., S.B., J.G.O.) and University of Washington (D.W.W.S., D.B., T.J., B.K., D.C., S.B., J.G.O.), Seattle.
David BreigerFrom the Seattle Children's Hospital and Research Institute (S.D.F., A.V.P., C.B., D.W.W.S., D.B., T.J., B.K., D.C, T.M.L., S.B., J.G.O.) and University of Washington (D.W.W.S., D.B., T.J., B.K., D.C., S.B., J.G.O.), Seattle.
Thomas JingujiFrom the Seattle Children's Hospital and Research Institute (S.D.F., A.V.P., C.B., D.W.W.S., D.B., T.J., B.K., D.C, T.M.L., S.B., J.G.O.) and University of Washington (D.W.W.S., D.B., T.J., B.K., D.C., S.B., J.G.O.), Seattle.
Brian KrabakFrom the Seattle Children's Hospital and Research Institute (S.D.F., A.V.P., C.B., D.W.W.S., D.B., T.J., B.K., D.C, T.M.L., S.B., J.G.O.) and University of Washington (D.W.W.S., D.B., T.J., B.K., D.C., S.B., J.G.O.), Seattle.
David CoppelFrom the Seattle Children's Hospital and Research Institute (S.D.F., A.V.P., C.B., D.W.W.S., D.B., T.J., B.K., D.C, T.M.L., S.B., J.G.O.) and University of Washington (D.W.W.S., D.B., T.J., B.K., D.C., S.B., J.G.O.), Seattle.
Tressa Mattioli LewisFrom the Seattle Children's Hospital and Research Institute (S.D.F., A.V.P., C.B., D.W.W.S., D.B., T.J., B.K., D.C, T.M.L., S.B., J.G.O.) and University of Washington (D.W.W.S., D.B., T.J., B.K., D.C., S.B., J.G.O.), Seattle.
Samuel BrowdFrom the Seattle Children's Hospital and Research Institute (S.D.F., A.V.P., C.B., D.W.W.S., D.B., T.J., B.K., D.C, T.M.L., S.B., J.G.O.) and University of Washington (D.W.W.S., D.B., T.J., B.K., D.C., S.B., J.G.O.), Seattle.
Jeffrey G OjemannFrom the Seattle Children's Hospital and Research Institute (S.D.F., A.V.P., C.B., D.W.W.S., D.B., T.J., B.K., D.C, T.M.L., S.B., J.G.O.) and University of Washington (D.W.W.S., D.B., T.J., B.K., D.C., S.B., J.G.O.), Seattle. jeff.ojemann@seattlechildrens.org.
BC Research (Canada) · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate whether frontal-lobe magnetic resonance spectroscopy measures of γ-aminobutyric acid (GABA) would be altered in a sample of adolescents scanned after sport concussion because mild traumatic brain injury is often associated with working memory problems.

methodsEleven adolescents (age 14-17 years) who had sustained a first-time sport concussion were studied with MRI/magnetic resonance spectroscopy within 23 to 44 days after injury (mean 30.4 ± 6.1 days). Age- and sex-matched healthy controls, being seen for sports-related injuries not involving the head and with no history of concussion, were also examined. GABA/creatine + phosphocreatine (Cre) was measured in left-sided frontal lobe and central posterior cingulate regions. The frontal voxel was positioned to overlap with patient-specific activation on a 1-back working memory task.

resultsIncreased GABA/Cre was shown in the frontal lobe for the concussed group. A decreased relationship was observed in the parietal region. High correlations between GABA/Cre and task activation were observed for the control group in the frontal lobe, a relationship not shown in the concussed participants.

conclusionsGABA/Cre appears increased in a region colocalized with working memory task activation after sport concussion. Further work extending these results in larger samples and at time points across the injury episode will aid in refining the clinical significance of these observations.

Indexed as

AdolescentAthletic InjuriesBrain ConcussionCase-Control StudiesChildChild, PreschoolCreatineFemaleFrontal Lobegamma-Aminobutyric AcidGyrus CinguliHumansMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMaleMemory, Short-TermCreatinegamma-Aminobutyric AcidOxygen

Identifiers

PMID29030453
PMCPMC5696637
OpenAlexW2762983780

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.