Evidence map›Paper›PMID 29030434›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2017

Cadherin-10 Maintains Excitatory/Inhibitory Ratio through Interactions with Synaptic Proteins.

Katharine R Smith, Kelly A Jones, Katherine J Kopeikina, Alain C Burette, Bryan A Copits, Sehyoun Yoon, Marc P Forrest, Jessica M Fawcett-Patel, Jonathan G Hanley, Richard J Weinberg and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 29 citations in OpenAlex.

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  18. Ankyrins: Roles in synaptic biology and pathology.Molecular and cellular neurosciences · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 4 countries.

Katharine R SmithDepartments of Physiology, katharine.r.smith@ucdenver.edu p-penzes@northwestern.edu.ORCID 0000-0002-4762-7201
Kelly A JonesDepartments of Physiology.
Katherine J KopeikinaDepartments of Physiology.
Alain C BuretteDepartment of Cell Biology and Physiology, University of North Carolina, Chapel Hill, North Carolina 27599, and.
Bryan A CopitsPharmacology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611.
Sehyoun YoonDepartments of Physiology.ORCID 0000-0001-6545-3615
Marc P ForrestDepartments of Physiology.
Jessica M Fawcett-PatelDepartments of Physiology.
Jonathan G HanleyFaculty of Biomedical Sciences, School of Biochemistry, University of Bristol, Bristol BS8 1TD, United Kingdom.ORCID 0000-0003-1704-4707
Richard J WeinbergDepartment of Cell Biology and Physiology, University of North Carolina, Chapel Hill, North Carolina 27599, and.ORCID 0000-0001-9689-7278
Geoffrey T SwansonPharmacology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611.ORCID 0000-0002-6645-9733
Peter PenzesDepartments of Physiology, katharine.r.smith@ucdenver.edu p-penzes@northwestern.edu.ORCID 0000-0001-5449-1640
Czech Academy of Sciences, Institute of Physiology · CZNorthwestern University · USUniversity of North Carolina at Chapel Hill · USUniversity of Bristol · GB

Funding

Small GTPase signaling in spinesR01MH071316 · NIMH · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BARBOLINA, MARIA V., PENZES, PETER · 2005 to 2025
$7.1M
The Supramolecular Architecture of the Postsynaptic DensityR01NS039444 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WEINBERG, RICHARD J · 2000 to 2021
$6.1M
Synaptic and dendritic dysfunction in psychiatric disordersR01MH097216 · NIMH · NORTHWESTERN UNIVERSITY AT CHICAGO · PI PENZES, PETER · 2012 to 2021
$6.1M
Postsynaptic roles of ankyrinsR01MH107182 · NIMH · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Peter Penzes · 2015 to 2026
$5.6M
Postsynaptic functions of neuronal adhesion molecules: focus on Cntnap2R01NS100785 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI PENZES, PETER · 2017 to 2020
$2.0M
Role of 4.1 proteins in kainate receptor localization and functionR01NS071952 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SWANSON, GEOFFREY T · 2010 to 2013
$1.3M
NIMH NIH HHS R01 MH071316NIMH NIH HHS R01 MH097216NIMH NIH HHS R01 MH107182NINDS NIH HHS R01 NS039444NINDS NIH HHS R01 NS071952NINDS NIH HHS R01 NS100785
6 · The paper itself

Abstract

Appropriate excitatory/inhibitory (E/I) balance is essential for normal cortical function and is altered in some psychiatric disorders, including autism spectrum disorders (ASDs). Cell-autonomous molecular mechanisms that control the balance of excitatory and inhibitory synapse function remain poorly understood; no proteins that regulate excitatory and inhibitory synapse strength in a coordinated reciprocal manner have been identified. Using super-resolution imaging, electrophysiology, and molecular manipulations, we show that cadherin-10, encoded by

Indexed as

AnimalsCadherinsCells, CulturedDisks Large Homolog 4 ProteinExcitatory Postsynaptic PotentialsFemaleHEK293 CellsHumansInhibitory Postsynaptic PotentialsMaleMiceProtein BindingRatsRats, Sprague-DawleySynapsesCadherinsCdh10 protein, mouseDisks Large Homolog 4 ProteinDlg4 protein, ratadhesioncadherin-10CDH10dendritic spinesinhibitory synapsesPSD-95

Identifiers

PMID29030434
PMCPMC5688522
OpenAlexW2762698112

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.