SynthesisCirculation. Cardiovascular genetics2017
New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475 000 Individuals.
Open access · diamondAbstract readMeta-Analysis
In one paragraph
Synthesis in Circulation. Cardiovascular genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 2 pooled it
6.6field-weighted citation impact, top 3% of its field
What it found
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals.Nature genetics · 2020Pooled it
- Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution.Nature genetics · 2019Pooled it
- NADPH oxidases: redox regulation of cell homeostasis and disease.Physiological reviews · 2025Review
- Ultra-processed food, genetic predisposition, and the risk of kidney stone: a population-based prospective cohort study.European journal of nutrition · 2025Article
- Large-Scale Multi-Omics Studies Provide New Insights into Blood Pressure Regulation.International journal of molecular sciences · 2022Article
- Whole-Genome Sequencing of 100 Genomes Identifies a Distinctive Genetic Susceptibility Profile of Qatari Patients with Hypertension.Journal of personalized medicine · 2022Article
- Central role of c-Src in NOX5- mediated redox signalling in vascular smooth muscle cells in human hypertension.Cardiovascular research · 2022Article
- Multi-Omics Integration in a Twin Cohort and Predictive Modeling of Blood Pressure Values.Omics : a journal of integrative biology · 2022Article
- Heritability and genome-wide association study of blood pressure in Chinese adult twins.Molecular genetics & genomic medicine · 2021Article
- Arterial Hypertension: Individual Therapeutic Approaches-From DNA Sequencing to Gender Differentiation and New Therapeutic Targets.Pharmaceutics · 2021Review
- Oxidative Stress and Hypertension.Circulation research · 2021Review
- NOX5-induced uncoupling of endothelial NO synthase is a causal mechanism and theragnostic target of an age-related hypertension endotype.PLoS biology · 2020Article
- Derivation and validation of genome-wide polygenic score for urinary tract stone diagnosis.Kidney international · 2020Article
- Association of Established Blood Pressure Loci With 10-Year Change in Blood Pressure and Their Ability to Predict Incident Hypertension.Journal of the American Heart Association · 2020Article
- Oxidative Stress: A Unifying Paradigm in Hypertension.The Canadian journal of cardiology · 2020Review
- NOX-Dependent Signaling Dysregulation in Severe COVID-19: Clues to Effective Treatments.Frontiers in cellular and infection microbiology · 2020Review
- Over 1000 genetic loci influencing blood pressure with multiple systems and tissues implicated.Human molecular genetics · 2019Review
- Genome-wide association studies of structural birth defects: A review and commentary.Birth defects research · 2019Review
- Examination of the associations between mHypertension research : official journal of the Japanese Society of Hypertension · 2019Article
- NOX5: Molecular biology and pathophysiology.Experimental physiology · 2019Review
Corrections and comments
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Authors and funding
144 authors.
Aldi T Kraja
James P Cook
Helen R Warren
Praveen Surendran
Chunyu Liu
Evangelos Evangelou
Alisa K Manning
Niels Grarup
Fotios Drenos
Xueling Sim
Albert Vernon Smith
Najaf Amin
Alexandra I F Blakemore
Jette Bork-Jensen
Ivan Brandslund
Aliki-Eleni Farmaki
Cristiano Fava
Teresa Ferreira
Karl-Heinz Herzig
Ayush Giri
Franco Giulianini
Megan L Grove
Xiuqing Guo
Sarah E Harris
Christian T Have
Aki S Havulinna
He Zhang
Marit E Jørgensen
AnneMari Käräjämäki
Charles Kooperberg
Allan Linneberg
Louis Little
Yongmei Liu
Lori L Bonnycastle
Yingchang Lu
Reedik Mägi
Anubha Mahajan
Giovanni Malerba
Riccardo E Marioni
Hao Mei
Cristina Menni
Alanna C Morrison
Sandosh Padmanabhan
Walter Palmas
Alaitz Poveda
Rainer Rauramaa
Nigel William Rayner
Muhammad Riaz
Ken Rice
Melissa A Richard
Jennifer A Smith
Lorraine Southam
Alena Stančáková
Kathleen E Stirrups
Vinicius Tragante
Tiinamaija Tuomi
Ioanna Tzoulaki
Tibor V Varga
Stefan Weiss
Andrianos M Yiorkas
Robin Young
Weihua Zhang
Michael R Barnes
Claudia P Cabrera
He Gao
Michael Boehnke
Eric Boerwinkle
John C Chambers
John M Connell
Cramer K Christensen
Rudolf A de Boer
Ian J Deary
George Dedoussis
Panos Deloukas
Anna F Dominiczak
Marcus Dörr
Roby Joehanes
Todd L Edwards
Tõnu Esko
Myriam Fornage
Nora Franceschini
Paul W Franks
Giovanni Gambaro
Leif Groop
Göran Hallmans
Torben Hansen
Caroline Hayward
Oksa Heikki
Erik Ingelsson
Jaakko Tuomilehto
Marjo-Riitta Jarvelin
Sharon L R Kardia
Fredrik Karpe
Jaspal S Kooner
Timo A Lakka
Claudia Langenberg
Lars Lind
Ruth J F Loos
Markku Laakso
Mark I McCarthy
Olle Melander
Karen L Mohlke
Andrew P Morris
Colin N A Palmer
Oluf Pedersen
Ozren Polasek
Neil R Poulter
Michael A Province
Bruce M Psaty
Paul M Ridker
Jerome I Rotter
Igor Rudan
Veikko Salomaa
Nilesh J Samani
Peter J Sever
Tea Skaaby
Jeanette M Stafford
John M Starr
Pim van der Harst
Peter van der Meer
Understanding Society Scientific Group
Cornelia M van Duijn
Anne-Claire Vergnaud
Vilmundur Gudnason
Nicholas J Wareham
James G Wilson
Cristen J Willer
Daniel R Witte
Eleftheria Zeggini
Danish Saleheen
Adam S Butterworth
John Danesh
Folkert W Asselbergs
Louise V Wain
Georg B Ehret
Daniel I Chasman
Mark J Caulfield
Paul Elliott
Cecilia M Lindgren
Daniel Levy
Christopher Newton-Cheh
Patricia B Munroe
Joanna M M Howson
CHARGE EXOME BP, CHD Exome+, Exome BP, GoT2D:T2DGenes Consortia, The UK Biobank Cardio-Metabolic Traits Consortium Blood Pressure Working Group†
Funding
HRS Yrs29-34: Y33 SSA CoFundingU01AG009740 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jessica Faul, KENNETH M LANGA · 1990 to 2026
$555.8MUCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1MInstitute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8MUCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0MTracking and Evaluation CoreU54GM115428 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI MASON, SARAH · 2016 to 2025
$38.2MUNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel · 2001 to 2026
$36.3MClinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2MRegional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Scott Soleimanpour · 2013 to 2026
$24.3MIdentifying Genes for Type 2 Diabetes: FUSIONU01DK062370 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOEHNKE, MICHAEL L, SCOTT, LAURA J. · 2009 to 2021
$11.6MTargeted Genetic Analysis of T2D and Quantitative TraitsR01DK072193 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN L. MOHLKE · 2005 to 2026
$11.3MMulti-Ethnic Study of Atherosclerosis (MESA) StudyR01HL071205 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI ROTTER, JEROME I · 2003 to 2007
$10.4MExceptional Survival: Trajectories to Functional Aging (CHS All Stars)R01AG023629 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NEWMAN, ANNE B. · 2004 to 2016
$9.5MBiotechnology and Biological Sciences Research Council BB/F019394/1British Heart Foundation RG/08/014/24067British Heart Foundation RG/14/5/30893British Heart Foundation SP/13/2/30111Intramural NIH HHS Z01 HG000024Medical Research Council G0600237Medical Research Council G0601966Medical Research Council G0700704Medical Research Council G0700931Medical Research Council G1001799Medical Research Council G9521010Medical Research Council MC_PC_U127561128Medical Research Council MC_QA137853Medical Research Council MC_UU_12015/1Medical Research Council MR/K006584/1Medical Research Council MR/K026992/1Medical Research Council MR/L003120/1Medical Research Council MR/L01341X/1Medical Research Council MR/L01632X/1Medical Research Council MR/M013111/1Medical Research Council MR/N005813/1Medical Research Council MR/N01104X/1Medical Research Council MR/N01104X/2NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1 TR001881NCI NIH HHS UM1 CA182913NCRR NIH HHS UL1 RR025005NHGRI NIH HHS U01 HG004729NHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268200900041CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS HHSN268201300025CNHLBI NIH HHS HHSN268201300026CNHLBI NIH HHS HHSN268201300027CNHLBI NIH HHS HHSN268201300028CNHLBI NIH HHS HHSN268201300029CNHLBI NIH HHS HHSN268201300046CNHLBI NIH HHS HHSN268201300047CNHLBI NIH HHS HHSN268201300048CNHLBI NIH HHS HHSN268201300049CNHLBI NIH HHS HHSN268201300050CNHLBI NIH HHS N01 HC025195NHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085080NHLBI NIH HHS N01 HC085081NHLBI NIH HHS N01 HC085082NHLBI NIH HHS N01 HC085083NHLBI NIH HHS N01 HC085086NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS N01 WH032105NHLBI NIH HHS N01 WH032118NHLBI NIH HHS R01 HL043851NHLBI NIH HHS R01 HL071205NHLBI NIH HHS R01 HL071250NHLBI NIH HHS R01 HL071252NHLBI NIH HHS R01 HL071258NHLBI NIH HHS R01 HL071259NHLBI NIH HHS R01 HL080467NHLBI NIH HHS R01 HL087652NHLBI NIH HHS R01 HL093029NHLBI NIH HHS R01 HL103612NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL117078NHLBI NIH HHS R01 HL119443NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R21 HL123677NHLBI NIH HHS U01 HL080295NHLBI NIH HHS U01 HL120393NIA NIH HHS HHSN271201200022CNIA NIH HHS N01 AG062101NIA NIH HHS N01 AG062103NIA NIH HHS N01 AG062106NIA NIH HHS R01 AG023629NIA NIH HHS R03 AG046389NIA NIH HHS RC2 AG036495NIA NIH HHS RC4 AG039029NIA NIH HHS U01 AG009740NIDDK NIH HHS K24 DK080140NIDDK NIH HHS P30 DK020572NIDDK NIH HHS R01 DK072193NIDDK NIH HHS R01 DK078616NIDDK NIH HHS R01 DK093757NIDDK NIH HHS U01 DK062370NIDDK NIH HHS U01 DK085501NIEHS NIH HHS P30 ES010126NIGMS NIH HHS U54 GM115428NIMH NIH HHS R01 MH063706NIMH NIH HHS RL1 MH083268WHI NIH HHS N01 WH022110WHI NIH HHS N01 WH024152WHI NIH HHS N01 WH032100WHI NIH HHS N01 WH032108WHI NIH HHS N01 WH032111WHI NIH HHS N01 WH032115WHI NIH HHS N01 WH032119WHI NIH HHS N01 WH032122WHI NIH HHS N01 WH044221
Abstract
backgroundGenome-wide association studies have recently identified >400 loci that harbor DNA sequence variants that influence blood pressure (BP). Our earlier studies identified and validated 56 single nucleotide variants (SNVs) associated with BP from meta-analyses of exome chip genotype data. An additional 100 variants yielded suggestive evidence of association. METHODS AND
resultsHere, we augment the sample with 140 886 European individuals from the UK Biobank, in whom 77 of the 100 suggestive SNVs were available for association analysis with systolic BP or diastolic BP or pulse pressure. We performed 2 meta-analyses, one in individuals of European, South Asian, African, and Hispanic descent (pan-ancestry, ≈475 000), and the other in the subset of individuals of European descent (≈423 000). Twenty-one SNVs were genome-wide significant (
conclusionsWe report 4 novel loci associated with BP regulation, and 1 independent variant at an established BP locus. This analysis highlights several candidate genes with variation that alter protein function or gene expression for potential follow-up.
Indexed as
Genetic LociAntiportersBlood PressureCell Adhesion Molecules, NeuronalDatabases, FactualGenome-Wide Association StudyGenotypeHumansMicrofilament ProteinsPhenotypePolymorphism, Single NucleotideReceptors, Lymphocyte HomingAFAP1 protein, humanAntiportersCell Adhesion Molecules, NeuronalMicrofilament ProteinsReceptors, Lymphocyte HomingSLC4A1AP protein, humanSTAB1 protein, humanSYNPO2L protein, humanblood pressureexomegeneticsgenotypesample size
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