Evidence map›Paper›PMID 29030391›Full record

ArticleJournal of leukocyte biology2017

The effect of plasma auto-IgGs on CD4

Zhenwu Luo, Zejun Zhou, Elizabeth Ogunrinde, Tao Zhang, Zhen Li, Lisa Martin, Zhuang Wan, Hao Wu, Zhiqiang Qin, Tongwen Ou and 6 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of leukocyte biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.1field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Systemic translocation ofJournal of virology · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 8 institutions in 2 countries.

Zhenwu LuoDepartment of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina, USA.
Zejun ZhouDepartment of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina, USA.
Elizabeth OgunrindeDepartment of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina, USA.
Tao ZhangDepartment of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina, USA.
Zhen LiBeijing You'an Hospital, Capital Medical University, Fengtai District, Beijing, China.
Lisa MartinDivision of Infectious Diseases, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.
Zhuang WanDepartment of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina, USA.
Hao WuBeijing You'an Hospital, Capital Medical University, Fengtai District, Beijing, China.
Zhiqiang QinDepartment of Genetics, Louisiana Cancer Research Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA.
Tongwen OuCapital Medical University Affiliated XuanWu Hospital, Xicheng District, Beijing, China.
Jiafeng ZhangZhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China.
Lei MaBiologicals Department, Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kuming, China.
Guoyang LiaoBiologicals Department, Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kuming, China.
Sonya HeathDivision of Infectious Diseases, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA; and.
Lei HuangThe People's Liberation Army No. 302 Hospital, Treatment and Research Center for Infectious Diseases, Beijing, China huangleiwa@sina.com.
Wei JiangDepartment of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina, USA; jianw@musc.edu.
Medical University of South Carolina · USCapital Medical University · CNChinese Academy of Medical Sciences & Peking Union Medical College · CN302 Military Hospital of China · CNBeijing YouAn Hospital · CNLouisiana Cancer Research Center · USUniversity of Alabama at Birmingham · USZhejiang Center for Disease Control and Prevention · CN

Funding

Virology CoreP30AI027767 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI OLAF KUTSCH · 1988 to 2026
$84.1M
Tracking & Evaluation CoreU54GM104940 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Peter Todd Katzmarzyk · 2012 to 2026
$69.1M
Translational Science Laboratory Shared ResourceP30CA138313 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI RAYMOND N. DUBOIS · 2009 to 2026
$42.7M
Synergistic effect of HIV virions and bacterial LPS on memory B cell apoptosisR01AI091526 · NIAID · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI JIANG, WEI · 2011 to 2015
$1.4M
On the pathogenic role of anti-CD4 antibody in poor CD4+ T cell recovery after antiretroviral therapy in HIV diseaseR01AI128864 · NIAID · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI JIANG, WEI · 2017 to 2021
$1.1M
NCI NIH HHS P30 CA138313NIAID NIH HHS P30 AI027767NIAID NIH HHS R01 AI091526NIAID NIH HHS R01 AI128864NIGMS NIH HHS U54 GM104940
6 · The paper itself

Abstract

Although effective antiretroviral therapy (ART) suppresses HIV viral replication, prevents AIDS-related complications, and prolongs life, a proportion of patients fails to restore the patients' CD4

Indexed as

Antiretroviral Therapy, Highly ActiveAdultApoptosisAutoantibodiesCD4 Lymphocyte CountCD4-Positive T-LymphocytesCytotoxicity, ImmunologicFemaleHIV InfectionsHumansImmunoglobulin GKiller Cells, NaturalMaleMiddle AgedProtein BindingAutoantibodiesImmunoglobulin GARTautoantibodydiseaseHIV infection

Identifiers

PMID29030391
PMCPMC6608058
OpenAlexW2762538823

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.