Evidence map›Paper›PMID 29030297›Full record

ArticleNeurobiology of learning and memory2017

Impaired extinction of cued fear memory and abnormal dendritic morphology in the prelimbic and infralimbic cortices in VPAC2 receptor (VIPR2)-deficient mice.

Yukio Ago, Atsuko Hayata-Takano, Takuya Kawanai, Ryosuke Yamauchi, Shuto Takeuchi, Jesse D Cushman, Abha K Rajbhandari, Michael S Fanselow, Hitoshi Hashimoto, James A Waschek

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PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of learning and memory, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 27 citations in OpenAlex.

  1. Trial
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  8. Identification ofFrontiers in molecular neuroscience · 2023
    Article
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  11. Review
  12. Article
  13. Probing theFrontiers in neuroscience · 2021
    Review
  14. Article
  15. Review
  16. Article
  17. Immunomodulatory Roles of PACAP and VIP: Lessons from Knockout Mice.Journal of molecular neuroscience : MN · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Yukio AgoLaboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565-0871, Japan; Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
Atsuko Hayata-TakanoLaboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565-0871, Japan; Molecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Suita, Osaka 565-0871, Japan.
Takuya KawanaiLaboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565-0871, Japan.
Ryosuke YamauchiLaboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565-0871, Japan.
Shuto TakeuchiLaboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565-0871, Japan.
Jesse D CushmanNeurobehavioral Core Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC 27709, USA; Department of Psychology, Brain Research Institute, University of California Los Angeles, Los Angeles, CA 90095, USA.
Abha K RajbhandariSemel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA; Department of Psychology, Brain Research Institute, University of California Los Angeles, Los Angeles, CA 90095, USA.
Michael S FanselowSemel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA; Department of Psychology, Brain Research Institute, University of California Los Angeles, Los Angeles, CA 90095, USA.
Hitoshi HashimotoLaboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565-0871, Japan; Molecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Suita, Osaka 565-0871, Japan; Division of Bioscience, Institute for Datability Science, Osaka University, Suita, Osaka 565-0871, Japan.
James A WaschekSemel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA. Electronic address: jwaschek@mednet.ucla.edu.
Osaka University · JPUniversity of California, Los Angeles · USNational Institute of Environmental Health Sciences · USUniversity of Fukui · JP

Funding

Stem CellsP30HD004612 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BOOKHEIMER, SUSAN Y · 1985 to 2014
$19.5M
PACAP Signaling in Fear Circuitries Relevant to Post-Traumatic Stress DisorderR21MH098506 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FANSELOW, MICHAEL S, WASCHEK, JAMES A · 2013 to 2014
$424k
Dissecting the role of the amygdala intercalated cells in expression, generalization and extinction of stress-enhanced fear learningF32MH107212 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RAJBHANDARI, ABHA K · 2015 to 2017
$112k
NICHD NIH HHS P30 HD004612NIMH NIH HHS F32 MH107212NIMH NIH HHS R21 MH098506
6 · The paper itself

Abstract

The structurally related neuropeptides vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) have been implicated in stress regulation and learning and memory. Several bodies of research have shown the impact of the PACAP specific receptor PAC1 on fear memory, but the roles of other PACAP receptors in regulating fear stress responses remain to be elucidated. Here we aimed to investigate the effects of genetic deletion of VIPR2 encoding the VPAC2 receptor, which binds both VIP and PACAP, on fear-related memory and on dendritic morphology in the brain regions of the fear circuitry. Male VPAC2 receptor knockout (VPAC2-KO) and littermate wild-type control mice were subjected to Pavlovian fear conditioning paradigm. VPAC2-KO mice displayed normal acquisition of fear conditioning, contextual and cued fear memory, but impaired extinction of cued fear memory. Morphological analyses revealed reductions in cell body size and total branch number and length of apical and basal dendrites of prelimbic cortex neurons in VPAC2-KO mice. In addition, Sholl analysis indicated that the amount of dendritic material distal to the soma was decreased, while proximal dendritic material was increased. In the infralimbic cortex, the amount of apical dendritic material proximal to the soma was increased in VPAC2-KO mice, while other indices of morphology did not differ. Finally, there were no differences in dendritic morphology in basolateral amygdala neurons between genotypes. These findings suggest that the VPAC2 receptor plays an important role in the fear extinction processes and the regulation of the dendritic morphology in the prelimbic and infralimbic cortices.

Indexed as

DendritesAnimalsConditioning, ClassicalCuesExtinction, PsychologicalFearMaleMice, Inbred C57BLMice, KnockoutPrefrontal CortexReceptors, Vasoactive Intestinal Peptide, Type IIReceptors, Vasoactive Intestinal Peptide, Type IIVipr2 protein, mouseDendritic morphologyExtinctionFear conditioningPrelimbic and infralimbic corticesVPAC2 receptor (VIPR2)

Identifiers

PMID29030297
PMCPMC5698124
OpenAlexW2763004411

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.