Evidence map›Paper›PMID 29029991›Full record

ReviewAnnals of epidemiology2017

Summary measures of agreement and association between many raters' ordinal classifications.

Aya A Mitani, Phoebe E Freer, Kerrie P Nelson

Abstract readReview
In one paragraph

Review in Annals of epidemiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Aya A MitaniDepartment of Biostatistics, Boston University School of Public Health, Boston, MA. Electronic address: amitani@bu.edu.
Phoebe E FreerDepartment of Radiology and Imaging Sciences, University of Utah Hospital and Huntsman Cancer Institute, Salt Lake City.
Kerrie P NelsonDepartment of Biostatistics, Boston University School of Public Health, Boston, MA.

Funding

Model Agreement in Cancer Diagnostic TestsR01CA172463 · NCI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI NELSON, KERRIE P · 2014 to 2017
$995k
NCI NIH HHS HHSN261201100031CNCI NIH HHS R01 CA172463
6 · The paper itself

Abstract

purposeInterpretation of screening tests such as mammograms usually require a radiologist's subjective visual assessment of images, often resulting in substantial discrepancies between radiologists' classifications of subjects' test results. In clinical screening studies to assess the strength of agreement between experts, multiple raters are often recruited to assess subjects' test results using an ordinal classification scale. However, using traditional measures of agreement in some studies is challenging because of the presence of many raters, the use of an ordinal classification scale, and unbalanced data.

methodsWe assess and compare the performances of existing measures of agreement and association as well as a newly developed model-based measure of agreement to three large-scale clinical screening studies involving many raters' ordinal classifications. We also conduct a simulation study to demonstrate the key properties of the summary measures.

resultsThe assessment of agreement and association varied according to the choice of summary measure. Some measures were influenced by the underlying prevalence of disease and raters' marginal distributions and/or were limited in use to balanced data sets where every rater classifies every subject. Our simulation study indicated that popular measures of agreement and association are prone to underlying disease prevalence.

conclusionsModel-based measures provide a flexible approach for calculating agreement and association and are robust to missing and unbalanced data as well as the underlying disease prevalence.

Indexed as

MammographyObserver VariationBreast NeoplasmsComputer GraphicsData Interpretation, StatisticalFemaleHumansMass ScreeningReproducibility of ResultsAgreementAssociationCohen's kappaOrdinal classificationWeighted kappa

Identifiers

PMID29029991
PMCPMC5687310

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.