ArticleMolecular biology and evolution2017
Genetic Interaction Network as an Important Determinant of Gene Order in Genome Evolution.
Article in Molecular biology and evolution, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 19 citations in OpenAlex.
- Co-transfer of functionally interdependent genes contributes to genome mosaicism in lambdoid phages.Microbial genomics · 2022Article
- Article
- Transcriptome Analysis in Yeast Reveals the Externality of Position Effects.Molecular biology and evolution · 2021Article
- Gene-gene interaction: the curse of dimensionality.Annals of translational medicine · 2019Review
- Synchronized replication of genes encoding the same protein complex in fast-proliferating cells.Genome research · 2019Article
- Modification of the genome topology network and its application to the comparison of group B Streptococcus genomes.BMC genomics · 2019Article
- Recombination drives the evolution of mutational robustness.Current opinion in systems biology · 2019Article
- Gene Repositioning Is Under Constraints After Evolutionary Conserved Gene Neighborhood Separate.Frontiers in genetics · 2019Article
- Natural selection interacts with recombination to shape the evolution of hybrid genomes.Science (New York, N.Y.) · 2018Article
- Screening of Genes Related to Early and Late Flowering in Tree Peony Based on Bulked Segregant RNA Sequencing and Verification by Quantitative Real-Time PCR.Molecules (Basel, Switzerland) · 2018Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although it is generally accepted that eukaryotic gene order is not random, the basic principles of gene arrangement on a chromosome remain poorly understood. Here, we extended existing population genetics theories that were based on two-locus models and proposed a hypothesis that genetic interaction networks drive the evolution of eukaryotic gene order. We predicted that genes with positive epistasis would move toward each other in evolution, during which a negative correlation between epistasis and gene distance formed. We tested and confirmed our prediction with computational simulations and empirical data analyses. Importantly, we demonstrated that gene order in the budding yeast could be successfully predicted from the genetic interaction network. Taken together, our study reveals the role of the genetic interaction network in the evolution of gene order, extends our understanding of the encoding principles in genomes, and potentially offers new strategies to improve synthetic biology.
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