ArticleCerebral cortex (New York, N.Y. : 1991)2018
Gamma-Band Oscillations Preferential for Nociception can be Recorded in the Human Insula.
Article in Cerebral cortex (New York, N.Y. : 1991), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 57 citations in OpenAlex.
- The Human Insula Reimagined: Single Neurons Respond to Simple Sounds during Passive Listening.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- The Role of Insular Cortex and Prefrontal Cortex in the Pathogenesis of Fibromyalgia: Biochemical and Electrophysiological Rodent Study.Neurochemical research · 2025Article
- Human insula neurons respond to simple sounds during passive listening.bioRxiv : the preprint server for biology · 2025Article
- Decoding pain's neural rhythm: Gamma oscillation mechanisms, therapeutic modulation, and translational challenges in pain management.Frontiers in neuroscience · 2025Review
- An Innovative EEG-Based Pain Identification and Quantification: A Pilot Study.Sensors (Basel, Switzerland) · 2024Article
- Interindividual variability and individual stability of pain- and touch-related neuronal gamma oscillations.Journal of neurophysiology · 2023Article
- Post-injury pain and behaviour: a control theory perspective.Nature reviews. Neuroscience · 2023Review
- Mesolimbic dopamine release precedes actively sought aversive stimuli in mice.Nature communications · 2023Article
- The Role of the Insular Cortex in Pain.International journal of molecular sciences · 2023Review
- Confidence of probabilistic predictions modulates the cortical response to pain.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- In search of a composite biomarker for chronic pain by way of EEG and machine learning: where do we currently stand?Frontiers in neuroscience · 2023Review
- Towards the Objective Identification of the Presence of Pain Based on Electroencephalography Signals' Analysis: A Proof-of-Concept.Sensors (Basel, Switzerland) · 2022Article
- The role of gamma oscillations in central nervous system diseases: Mechanism and treatment.Frontiers in cellular neuroscience · 2022Review
- Cerebral processing of sharp mechanical pain measured with arterial spin labeling.Brain and behavior · 2022Article
- From nociception to pain perception, possible implications of astrocytes.Frontiers in cellular neuroscience · 2022Article
- Neocortical circuits in pain and pain relief.Nature reviews. Neuroscience · 2021Review
- The temporal and spectral characteristics of expectations and prediction errors in pain and thermoception.eLife · 2021Article
- Detecting acute pain signals from human EEG.Journal of neuroscience methods · 2021Article
- Insular responses to transient painful and non-painful thermal and mechanical spinothalamic stimuli recorded using intracerebral EEG.Scientific reports · 2020Article
- Involvement of Frontal Functions in Pain Tolerance in Aging: Evidence From Neuropsychological Assessments and Gamma-Band Oscillations.Frontiers in aging neuroscience · 2020Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Transient nociceptive stimuli elicit robust phase-locked local field potentials (LFPs) in the human insula. However, these responses are not preferential for nociception, as they are also elicited by transient non-nociceptive vibrotactile, auditory, and visual stimuli. Here, we investigated whether another feature of insular activity, namely gamma-band oscillations (GBOs), is preferentially observed in response to nociceptive stimuli. Although nociception-evoked GBOs have never been explored in the insula, previous scalp electroencephalography and magnetoencephalography studies suggest that nociceptive stimuli elicit GBOs in other areas such as the primary somatosensory and prefrontal cortices, and that this activity could be closely related to pain perception. Furthermore, tracing studies showed that the insula is a primary target of spinothalamic input. Using depth electrodes implanted in 9 patients investigated for epilepsy, we acquired insular responses to brief thermonociceptive stimuli and similarly arousing non-nociceptive vibrotactile, auditory, and visual stimuli (59 insular sites). As compared with non-nociceptive stimuli, nociceptive stimuli elicited a markedly stronger enhancement of GBOs (150-300 ms poststimulus) at all insular sites, suggesting that this feature of insular activity is preferential for thermonociception. Although this activity was also present in temporal and frontal regions, its magnitude was significantly greater in the insula as compared with these other regions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.