ArticleCerebral cortex (New York, N.Y. : 1991)2018
Latent-Profile Analysis Reveals Behavioral and Brain Correlates of Dopamine-Cognition Associations.
Article in Cerebral cortex (New York, N.Y. : 1991), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed.
- NMDA receptor involvement in dopaminergic modulation of neuroplasticity induced by paired associative stimulation.The international journal of neuropsychopharmacology · 2025Trial
- Fronto-striatal dopamine D2 receptor availability is associated with cognitive variability in older individuals with low dopamine integrity.Scientific reports · 2021Trial
- Self-Reported ADHD Symptoms and Cognitive Performance in a National Sample of US Older Adults.Journal of attention disorders · 2026Article
- 10-year longitudinal dopamine D2-receptor losses are associated with cognitive decline in healthy aging.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Aging-related losses in dopamine D2/3 receptor availability are linked to working-memory decline across five years.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Associations between inflammation and striatal dopamine D2-receptor availability in aging.Journal of neuroinflammation · 2025Article
- Review
- The Development and Full Validation of a Novel Liquid Chromatography Electrochemical Detection Method for Simultaneous Determination of Nine Catecholamines in Rat Brain.Turkish journal of pharmaceutical sciences · 2023Article
- Individual differences in brain aging: heterogeneity in cortico-hippocampal but not caudate atrophy rates.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- White matter lesion load determines exercise-induced dopaminergic plasticity and working memory gains in aging.Translational psychiatry · 2023Article
- Multivariate associations between dopamine receptor availability and risky investment decision-making across adulthood.Cerebral cortex communications · 2023Article
- NMDA receptor-related mechanisms of dopaminergic modulation of tDCS-induced neuroplasticity.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Pharmacological targeting of cognitive impairment in depression: recent developments and challenges in human clinical research.Translational psychiatry · 2022Review
- Article
- Contributions of the Catechol-O-Methyltransferase Val158Met Polymorphism to Changes in Brain Iron Across Adulthood and Their Relationships to Working Memory.Frontiers in human neuroscience · 2022Article
- Influences of dopaminergic system dysfunction on late-life depression.Molecular psychiatry · 2022Review
- The Aged Striatum: Evidence of Molecular and Structural Changes Using a Longitudinal Multimodal Approach in Mice.Frontiers in aging neuroscience · 2022Article
- Severity of alcohol use disorder influences sex differences in sleep, mood, and brain functional connectivity impairments.Brain communications · 2022Article
- Hippocampal and Parahippocampal Gray Matter Structural Integrity Assessed by Multimodal Imaging Is Associated with Episodic Memory in Old Age.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Striatal Dopamine and Reward Prediction Error Signaling in Unmedicated Schizophrenia Patients.Schizophrenia bulletin · 2020Article
Corrections and comments
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Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Evidence suggests that associations between the neurotransmitter dopamine and cognition are nonmonotonic and open to modulation by various other factors. The functional implications of a given level of dopamine may therefore differ from person to person. By applying latent-profile analysis to a large (n = 181) sample of adults aged 64-68 years, we probabilistically identified 3 subgroups that explain the multivariate associations between dopamine D2/3R availability (probed with 11C-raclopride-PET, in cortical, striatal, and hippocampal regions) and cognitive performance (episodic memory, working memory, and perceptual speed). Generally, greater receptor availability was associated with better cognitive performance. However, we discovered a subgroup of individuals for which high availability, particularly in striatum, was associated with poor performance, especially for working memory. Relative to the rest of the sample, this subgroup also had lower education, higher body-mass index, and lower resting-state connectivity between caudate nucleus and dorsolateral prefrontal cortex. We conclude that a smaller subset of individuals induces a multivariate non-linear association between dopamine D2/3R availability and cognitive performance in this group of older adults, and discuss potential reasons for these differences that await further empirical scrutiny.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.